Medicube Zero Exosome Shot for sensitive skin
Lacto Exosome
Niacinamide
Betaine Salicylate
Adenosine
Hydrolyzed Sponge
Average
- AverageNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2002
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for normal skin, as niacinamide and gluconolactone work to even skin tone and smooth texture, while glycerin provides humectant action. However, the formula lacks targeted anti-inflammatory or barrier-repairing ingredients to effectively address your redness and irritation concerns.
- Panthenol is included for hydration, but the emollient support is not robust enough to fully counteract potential dryness for your normal skin with sensitivity.
- The product is safe for your normal skin with sensitivity, as it contains no harsh or prohibited ingredients that would cause irritation.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.7Overall rating based on 100+ reviewsUsers describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.
Highlights
Smoother texture Mostly Mentioned
- “bumpy texture is finally smooth”
- “skin feels silky smooth”
- “makeup glides on easier”
- “glass-like skin”
Prickly sensation Mostly Mentioned
- “feels like fiberglass”
- “stinging all over”
- “uncomfortable prickly feel”
- “like tiny needles poking”
Pore minimization Often Mentioned
- “black dots on my nose have all but disappeared”
- “pores are the smallest they've ever been”
- “immediate and certain pore tightening”
- “pores looked teeny tiny”
Radiance and glow Often Mentioned
- “radiates with a healthy glow”
- “skin looked noticeably brighter”
- “complexion looks clearer”
Enhanced absorption Sometimes Noted
- “makes all my serums work better”
- “acts as a pathway to enhance absorption”
- “products sink in deeper”
Skin irritation Sometimes Noted
- “led to redness and breakouts”
- “left me feeling raw”
- “too intense for sensitive skin”
- “caused irritation”
Lack of results Rarely Noted
- “skin looking the exact same”
- “didn't really work for me”
- “not sure what exactly this is doing”
Unpleasant texture Rarely Noted
- “sticky after-feel”
- “heavy on sensitive skin”
- “feels a bit tacky”
Sources: lovi.care, stylekorean.com, skinsort.com, medicube.us, instyle.com, newbeauty.com, and more
Questions and answers
How well does MEDICUBE Zero Exosome Shot work for sensitive skin?
This treatment works moderately well for sensitive skin, helping to smooth texture and even tone while keeping your skin safe from harsh ingredients. However, it lacks targeted anti-inflammatory and stronger barrier-repairing ingredients to properly soothe redness and irritation. Treatments that fit sensitive skin better need calming plant extracts and soothing barrier supporters to comfortably calm redness and irritation.
Which ingredients make this treatment a good fit for sensitive skin?
Niacinamide and gluconolactone help even skin tone and smooth texture, while glycerin and panthenol provide moisture. However, because this treatment lacks targeted anti-inflammatory and barrier-repairing ingredients to calm redness and irritation, sensitive skin needs a product with soothing and barrier-strengthening additions.
American Journal of Clinical Dermatology, 2002The Journal of Dermatological Treatment, 2017
What does Lacto Exosome do for sensitive skin?
Lacto Exosome helps strengthen the skin barrier by boosting key proteins that keep dry or sensitive skin protected and hydrated. It is unlikely to irritate and may improve how well your skin holds onto moisture.
What does Niacinamide do for sensitive skin?
Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Where does this treatment go in a skincare routine for sensitive skin?
This treatment goes in your evening routine, placed after your soothing toner and before your moisturizer. Treatments with active ingredients are kept to the evening for simplicity and extra safety around sun exposure. Because this formula lacks targeted soothing or strong barrier-repairing ingredients for sensitive skin, a product of this type needs calming plant extracts, gentle hydrators, and skin-repairing ceramides to fully comfort redness and dryness.
Can I use it with retinol, and in what order?
You can use this treatment with retinol, but because it may cause dryness and irritation on sensitive skin, apply your retinol on a separate night or use gentle soothing ingredients and barrier-repairing support to keep skin calm and smooth.
How often should I use it?
This treatment should be used once a week in your evening routine to help your sensitive skin adjust safely. Sensitive skin of this type needs products with soothing, anti-inflammatory, and strong barrier-repairing ingredients to calm redness and irritation while preventing dryness.
Can it clog pores, cause breakouts or purging for sensitive skin?
MEDICUBE Zero Exosome Shot is unlikely to clog pores or cause breakouts for sensitive skin, though it may cause a prickly sensation or skin irritation for some people. A product of this type needs soothing and barrier-repairing ingredients to calm redness and protect sensitive skin effectively.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation.
Biological & Pharmaceutical Bulletin, 2019Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects.
The Journal of Craniofacial Surgery, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation.
International Journal of Molecular Sciences, 2025Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone.
International Journal of Nanomedicine, 2020The topical combination of Sph12-38 and sponge spicules achieved a 100% cure rate in rabbit ear acne treatment over two weeks compared to 40% for SHS alone, 0% for Sph12-38 alone, and 0% for the control group.
Drug Delivery and Translational Research, 2025
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016
Ingredients
Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.