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Medicube One Day Exosome Shot 2000 for oily skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Medicube One Day Exosome Shot 2000

High

  • SuperiorOily Skin Fit
  • AverageEffectiveness
  • HighSafety

A great choice for oily skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Excellent suitability for your oily skin is provided by niacinamide for seboregulation and betaine salicylate for keratolytic action, promoting skin regeneration and chemical exfoliation.
  • Glycerin and panthenol offer general skincare benefits like hydration, which are supportive for your oily shine concerns.
  • The product is safe for your oily skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
  • Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
  • Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
  • Avoid the delicate eye area and do a patch test before using the serum for the very first time.

People Say

★4.7Overall rating based on 200+ reviews

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

Highlights

  • Smoother skin texture Mostly Mentioned
    • “Skin is visibly smoother and refined”
    • “Bumpy texture is finally smooth”
    • “Leaves skin feeling silky soft”
  • Prickly/tingling sensation Mostly Mentioned
    • “Feels like rubbing little needles into skin”
    • “Sensation is not exactly pleasant”
    • “Tingling was too painful for me”
  • Pore tightening Often Mentioned
    • “Pores on my nose and chin are the smallest they've ever been”
    • “Tightens open and saggy pores”
    • “Visible refinement in my pores after a week”
  • Blackhead reduction Sometimes Noted
    • “Black dots on my nose all but disappeared”
    • “Reduced my whiteheads significantly”
    • “Great for clearing clogged pores”
  • Fast results Sometimes Noted
    • “Noticed a difference the very first week”
    • “Quick texture fix”
    • “Skin looked brighter after first use”
  • Can be drying Rarely Noted
    • “Can cause dryness near lips”
    • “Needs a nourishing moisturizer after”
    • “Felt a bit stripping on dry areas”
  • Skin irritation/breakouts Rarely Noted
    • “Broke me out after 3 days”
    • “Caused redness and increased sensitivity”
    • “Irritation made it less enjoyable”

Sources: lovi.care, stylekorean.com, medicube.us, iherb.com, amazon.com, skinsort.com, and more

Questions and answers

What makes Medicube One Day Exosome Shot 2000 a great fit for oily skin?

This treatment is a great fit for your oily skin because niacinamide helps balance oil production while betaine salicylate gently clears away dead skin cells to keep pores clear. Glycerin and panthenol add light hydration, and the formula is safe and unlikely to cause irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

Which ingredients make this treatment a good fit for oily skin?

Niacinamide helps balance oil, while betaine salicylate provides gentle chemical exfoliation to support skin renewal. Glycerin and panthenol add light hydration, and the formula is safe and unlikely to cause irritation on oily skin.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

What do Lactobacillus Extracellular Vesicles do for oily skin?

Lactobacillus extracellular vesicles help calm irritated skin and support a balanced skin barrier. They are unlikely to clog pores and may reduce redness or inflammation in oily skin types.

Frontiers in Immunology, 2026International Journal of Biological Macromolecules, 2025

What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.

Journal of Cosmetic and Laser Therapy, 2006Antioxidants, 2021

Where does this treatment go in a skincare routine for oily skin?

This treatment goes in your evening routine, placed after cleansing and toning and before your moisturizer. Putting it in the evening helps keep things simple and adds extra safety around sun exposure, though some treatments may also be used in the morning or twice a day.

Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying it in your evening routine, as long as you introduce them slowly to avoid irritation. It is unlikely to cause discomfort when paired carefully, since the formula is gentle and well-tolerated by oily skin.

How often should I use this treatment?

You can use this treatment in your evening routine, starting just once a week. If your skin handles it well and you see good results, you may carefully use it more often.

Can this treatment clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to clog pores or cause breakouts on oily skin, as it has a very low risk of irritation and features niacinamide and betaine salicylate to help balance oil and gently clear away dead skin cells. While reviewers often note a prickly or tingling sensation during use, complaints about breakouts remain low.

Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

    Biomaterials Advances, 2022

  • A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

    Medicina Cutanea Ibero-latino-americana, 1986

  • Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

    Metabolites, 2021

  • Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline.

    Journal of Cosmetic Science, 2004

  • Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity.

    International Journal of Pharmaceutics, 2008

  • A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation.

    Chemical & Pharmaceutical Bulletin, 2010

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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Prices checked 6 Nov 2026

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play