Estée Lauder Revitalizing Supreme+ Youth Power Eye Balm for sensitive skin

Questions and answers

What the research says

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Emulgels containing Perilla frutescens seed oil, Moringa oleifera seed oil, and mixed seed oil microemulsions exhibit good stability, lack of cytotoxicity in PBMC, and no skin irritation or allergic reactions in human subjects.

  Polymers, 2022

• Aqueous standardized leaf extracts of Moringa oleifera showed the highest human dermal fibroblast and human keratinocyte proliferation and migration properties, leading to the development of an alginate-pectin film dressing with optimal physicochemical properties.

  Journal of Ethnopharmacology, 2018

• Topical administration of Moringa oleifera seed extract on excision wounds in male albino rabbits significantly increased the wound healing rate, elevated TGF-β1, VEGF, and Type I collagen relative expression, and reduced inflammatory markers like IL-1β and TNF-α compared to untreated and MEBO-treated groups.

  Antioxidants, 2022

• Moringa oleifera leaf extracts provided significant UV protection with an SPF of 2 at 2% to 4% concentrations and showed no significant irritant potential in cosmetic formulations.

  Molecules, 2018

• Hibiscus syriacus ethanolic extract stimulated fibronectin and collagen synthesis, fibroblast contractility, and wound healing activity in human skin cells and explants, while increasing skin hydration gene expression.

  BioMed Research International, 2017

• Polydeoxyribonucleotide derived from Hibiscus sabdariffa callus at 5 μg/mL promoted wound healing and upregulated related genes and proteins in human keratinocytes.

  Biochemical and Biophysical Research Communications, 2024

• Water extracts from Roselle leaves and callus cells exhibited different biochemical components, transcriptome profiles, and effects on human skin cells, with the callus extract demonstrating anti-melanogenic, skin barrier, and antioxidant activities, while the plant extract affected angiogenesis, oxidation-reduction, and glycolysis.

  International Journal of Molecular Sciences, 2023

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

  International Journal of Biological Macromolecules, 2026

• Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.

  Journal of Cosmetic Dermatology, 2007

• N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.

  Advanced Pharmaceutical Bulletin, 2016

• Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.

  Journal of Cosmetic and Laser Therapy, 2019

Ingredients

Water, Methyl Trimethicone, Propanediol, Isododecane, Polyethylene, Dimethicone, Butylene Glycol, Hydrogenated Polyisobutene, Dimethicone Vinyl Dimethicone Crosspolymer, Cetyl Peg Ppg-10 1 Dimethicone, Stearyl Dimethicone, Nylon-12, Isononyl Isononanoate, Moringa Oleifera Seed Extract, Hibiscus Sinensis Flower Extract, Sodium Hyaluronate, Acetyl Hexapeptide-8, Laminaria Digitata Extract, Whey Lactis Proteine Du Petit-Lait Protein, Opuntia Tuna Extract, Acetyl Glucosamine, Tocopheryl Acetate, Narcissus Tazetta Bulb Extract, Squalane, Hydrolyzed Rice Extract, Algae Extract, Limonium Vulgare Stem Extract Flower Leaf, Cucumis Sativus Fruit Extract, Silybum Marianum Extract, Mimosa Tenuiflora Bark Extract, Helianthus Annuus Seed Extract Sunflower Seed Extract, Sigesbeckia Orientalis Extract, Caffeine, Hordeum Vulgare Extract Extrait Dorge Extract, Wheat Extract Germ Extract, Propylene Glycol Dicaprate, Glucose, Magnesium Sulfate, Sucrose, Glycerin, Pinanediol, Camphanediol, Hexylene Glycol, Caprylyl Glycol, Boron Nitride, Maltodextrin, Aminopropyl Ascorbyl Phosphate, Methicone, Artemia Extract, Polysilicone-11, Alumina, Isoceteth-20, Disteardimonium Hectorite, Peg-10 Dimethicone, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Citric Acid, Octadecene, Triethoxycaprylylsilane, Disodium Edta, Bht, Potassium Sorbate, Chlorphenesin, Phenoxyethanol, Titanium Dioxide Ci 77891, Iron Oxides Ci 77491

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.