Some By Mi Yuja Niacin Brightening Toner for sensitive skin

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Questions and answers

What the research says

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate.

  Experimental Dermatology, 2012

• A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• Citrus junos callus extract decreased melanin content in melanocytes 1.85-fold compared with arbutin and promoted the proliferation of and procollagen synthesis by human fibroblasts by 154% and 176% at 500 μg/mL.

  Molecules, 2017

• Yuja-peel fractions (ethyl acetate, hexane, and butanol) inhibited MMP expression, induced moisturizing factors filaggrin and serine palmitoyltransferase, and decreased melanin content in UVB-irradiated HaCaT, HDF, and α-MSH-treated B16F10 cells.

  Antioxidants, 2022

• Upcycled low-molecular-weight anionic peptides from Citrus junos seeds protected UVR-irradiated keratinocytes and reconstructed skin tissue by scavenging reactive oxygen species, reducing paracrine cytokines, inhibiting melanin synthesis and TRP-2 expression, and increasing filaggrin, laminin-5, and type I collagen expression.

  International Journal of Molecular Sciences, 2024

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.

  Arzneimittel-Forschung, 2000

• Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.

  Auris, Nasus, Larynx, 2020

• Topical steroid withdrawal presents as a distinct dermatopathology characterized by burning, flushing, thermodysregulation, and elevated mitochondrial NAD+ oxidation, which can be improved by targeting complex I with metformin or berberine.

  MedRxiv, 2024

• Hydroxypropyl methylcellulose hydrogel formulations of berberine chloride-loaded escinosomes increased skin residence time and transdermal permeability while maintaining high safety and biocompatibility without skin irritation.

  International Journal of Biological Macromolecules, 2020

• A carboxymethyl cellulose-based hydrogel film loaded with berberine reduced keratinocyte hyperproliferation by 25% and controlled oxidative stress and inflammation markers in vitro.

  Carbohydrate Polymers, 2022

Ingredients

Citrus Junos Fruit Extract, Niacinamide, 1,2-Hexanediol, Glycerin, Polyglyceryl-10 Laurate, C12-14 Pareth-7, Water, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Citrus Junos Peel Oil, Butylene Glycol, Adenosine, Tromethamine, Disodium Edta, Coptis Chinensis Root Extract, Hydrogenated Lecithin, Polyglyceryl-10 Stearate, Panthenol, Sodium Ascorbyl Phosphate, Saussurea Involucrata Extract, Bisabolol, Maltodextrin, Hydrolyzed Protein, Sambucus Nigra Flower Extract, Citrus Aurantium Dulcis Flower Extract, Magnolia Liliflora Flower Extract, Plumeria Rubra Flower Extract, Lilium Tigrinum Extract, Folic Acid, Biotin, Pyridoxine, Pancratium Maritimum Extract, Tocopherol, Cyanocobalamin, Linoleic Acid, Thiamine Hcl, Beta-Carotene, Riboflavin, Inositol, Limonene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.