SKIN1004 Madagascar Centella Watergel Sheet Ampoule Mask for skin with dark spots

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Questions and answers

What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations.

  International Journal of Cosmetic Science, 2025

• Self-assembled cubic liquid crystalline nanoparticles loaded with paeonol reduced skin irritation compared to commercial ointment, serving as a promising transdermal delivery system.

  Medical Science Monitor, 2015

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of menthol-based cooling gel decreased intramuscular temperature by 1.9 °C and increased cutaneous blood flow by 0.3 ml/min in healthy males compared to placebo gel.

  International Journal of Sports Physical Therapy, 2018

• Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers.

  Neuroscience Letters, 1995

• Topical 3.5% menthol gel decreased pain perception and resulted in 116.9% higher tetanic force compared to ice in 16 subjects with delayed onset muscle soreness.

  International Journal of Sports Physical Therapy, 2012

• Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers.

  Journal of Cosmetic Science, 2006

• Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control.

  International Journal of Cosmetic Science, 2016

• Paeonia suffruticosa and its main compound paeonol ameliorated UVB-induced skin photoaging by regulating the DLD/Nrf2/ARE and MAPK/AP-1 pathways in keratinocytes and hairless mice, preventing procollagen type I degradation and reducing matrix metalloproteinase-1 production.

  Phytotherapy Research, 2018

• A 1.0% w/w cocoa pod husk extract lotion improved skin hydration by 52.48%, reduced transepidermal water loss by 7.73%, and decreased the melanin index by 9.10% in 30 volunteers after 4 weeks of application compared to baseline.

  Life, 2025

• Application of cocoa pod extract gel reduced skin wrinkles by 6.38% at 3 weeks and 12.39% at 5 weeks, and increased skin hydration by 3.18% at 3 weeks in 12 panelists.

  Journal of Cosmetic Dermatology, 2016

• Cocoa polyphenols improved indicators of skin elasticity and tonus including glycosaminoglycans and collagens I, III, and IV in ex vivo human skin explants with an efficacy equivalent to a commercially available product.

  International Journal of Cosmetic Science, 2008

Ingredients

Centella Asiatica Extract, Water, Dipropylene Glycol, Glycereth-26, Glycerin, 1,2-Hexanediol, Betaine, Butylene Glycol, Paeonia Suffruticosa Root Extract, Polyglyceryl-10 Laurate, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glyceryl Caprylate, Carbomer, Xanthan Gum, Arginine, Ethylhexylglycerin, Sodium Hyaluronate, Dextrin, Theobroma Cacao Extract, Propanediol, Coptis Japonica Root Extract, Mentha Arvensis Oil Leaf, Sodium Hyaluronate Crosspolymer, Hydrolyzed Glycosaminoglycans, Benzyl Glycol, Hydrolyzed Hyaluronic Acid, Raspberry Ketone, Disodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.