Acetyl hexapeptide-3 and superoxide dismutase
Keep them apart
Use them at different times of day, applying the peptide first and the enzyme later, because they cancel each other out. Superoxide dismutase can break down acetyl hexapeptide-3, which stops the peptide from smoothing fine lines and firming the skin. The shopper can separate them by morning and night to get the best results from both products.
Acetyl hexapeptide-3 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
€30.99
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The Ordinary
Multi-Peptide + HA Serum
€17.89
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Medik8
Liquid Peptides
€109.17
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La Mer
The Treatment Lotion
€148.20
- Rhode Peptide Glazing Fluid
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The Ordinary
Argireline Solution 10%
€10.99
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Good Molecules
Super Peptide Serum
€27.95
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Clinique
Smart Clinical Repair Wrinkle Correcting Serum
€88.99
- La Mer The Renewal Oil
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Estée Lauder
Micro Essence Treatment Lotion
€58.65
- The INKEY List Collagen Peptide Serum
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La Mer
The Eye Concentrate
€180.90
Superoxide dismutase products
- iS Clinical Reparative Moisture Emulsion
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U Beauty
Resurfacing Compound
€226.80
- Skinbetter Science Alto Advanced Defense and Repair Serum
- Skin Better Science Alto Advanced Defense and Repair Serum
- Skinbetter Science Alto Defense Serum
- NIOD Modulating Glucosides
-
Charlotte Tilbury
Magic Eye Rescue
€91.54
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Paula's Choice
RESIST Super Antioxidant Concentrate Serum
€57.00
- Image Skincare Vital C Hydrating Enzyme Masque
- NIOD Superoxide Dismutase Saccharide Mist
- Dr. Dennis Gross C + Collagen Biocellulose Brightening Treatment Mask
Questions and answers
Can you use acetyl hexapeptide-3 and superoxide dismutase together?
Keep acetyl hexapeptide-3 and superoxide dismutase apart because enzymes degrade peptides and render them inactive.
Which goes first, acetyl hexapeptide-3 or superoxide dismutase?
Keep acetyl hexapeptide-3 and superoxide dismutase apart because enzymes or proteases can degrade peptide bonds and render the active inactive.
Are acetyl hexapeptide-3 and superoxide dismutase good for sensitive skin?
Keep acetyl hexapeptide-3 and superoxide dismutase apart in your routine because enzymes degrade peptides and render them inactive.
Research on acetyl hexapeptide-3 and superoxide dismutase
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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