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Hexapeptide-9 and protease

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Hexapeptide-9 and protease: keep them apart

Keep them apart

Use them at different times of day, applying the hexapeptide-9 first and the protease later, because they cancel each other out. Protease breaks down the firming bonds of hexapeptide-9, making the peptide useless on your skin. You can separate them by using one in the morning and the other at night.

Hexapeptide-9 products

Protease products

Questions and answers

Can you use hexapeptide-9 and protease together?

No, you should keep hexapeptide-9 and protease apart in your skincare routine because proteases may degrade peptide bonds and render hexapeptide-9 inactive.

Which goes first, hexapeptide-9 or protease?

You should keep hexapeptide-9 and protease apart because proteases may degrade peptide bonds and render the active inactive. It is best to use them in separate routines.

Are hexapeptide-9 and protease good for sensitive skin?

Keep hexapeptide-9 and protease apart in your routine because the protease degrades peptide bonds and renders hexapeptide-9 inactive. Lovi rates this combination as having Average compatibility for all skin types.

Research on hexapeptide-9 and protease

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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