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Tretinoin and hexapeptide-9

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Tretinoin and hexapeptide-9: keep them apart

Keep them apart

Use them at different times of day, applying hexapeptide-9 in the morning and tretinoin at night, because combining them in the same routine can cause irritation. Both ingredients work hard to firm and smooth the skin, but using them together can overwhelm your face and cause redness and flaking. You can prevent this by using them at different times of day or choosing a gentler peptide product.

Tretinoin products

Hexapeptide-9 products

Questions and answers

Can you use tretinoin and hexapeptide-9 together?

No, you should keep them apart because combined stimulation may increase irritation, so use your tretinoin at night and hexapeptide-9 in the morning.

Which goes first, tretinoin or hexapeptide-9?

Keep tretinoin and hexapeptide-9 apart because combined stimulation may increase irritation. Alternate your usage by applying your retinoid in the PM and peptides in the AM.

Are tretinoin and hexapeptide-9 good for sensitive skin?

Tretinoin and hexapeptide-9 should be kept apart in your routine because combining them may increase irritation on sensitive skin. Alternate their usage by applying your retinoid in the evening and peptides in the morning.

Research on tretinoin and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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