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Acetyl hexapeptide-3 and protease

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Acetyl hexapeptide-3 and protease: keep them apart

Keep them apart

Use them at different times of day, applying acetyl hexapeptide-3 in the morning and protease at night, because they clash when mixed. Protease breaks down the firming bonds of acetyl hexapeptide-3, ruining the anti-aging benefits you want to see. You can easily fix this by applying them hours apart or on alternate days.

Acetyl hexapeptide-3 products

Protease products

Questions and answers

Can you use acetyl hexapeptide-3 and protease together?

No, you should keep acetyl hexapeptide-3 and protease apart because proteases degrade peptide bonds and render the active peptide inactive. Avoid using these two ingredients in the same routine.

Which goes first, acetyl hexapeptide-3 or protease?

Keep acetyl hexapeptide-3 and protease apart in your routine because the protease degrades the peptide bonds and renders the active inactive. If you use both, apply them at completely different times of day to avoid breaking down the peptide.

Are acetyl hexapeptide-3 and protease good for sensitive skin?

Acetyl hexapeptide-3 and protease should be kept apart in your routine because the protease can degrade the peptide bonds and render the active ingredient inactive. Lovi rates this combination as having average compatibility for all skin types.

Research on acetyl hexapeptide-3 and protease

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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