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Hexapeptide and pro-retinol

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Hexapeptide and pro-retinol: keep them apart

Keep them apart

Use them at different times of day by applying your pro-retinol at night and your hexapeptide in the morning to avoid extra skin irritation. Using both together can overwhelm your skin and cause redness because they are both very active anti-aging ingredients. You can fix this by using a gentler strength, or by putting more time between applying the two products.

Hexapeptide products

Pro-retinol products

Questions and answers

Can you use hexapeptide and pro-retinol together?

No, you should keep hexapeptide and pro-retinol apart in your routine because combining them may increase skin irritation. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning.

Which goes first, hexapeptide or pro-retinol?

Keep hexapeptide and pro-retinol apart in your routine because combining them may increase skin irritation. You can alternate usage by applying the retinoid in the PM and peptides in the AM.

Are hexapeptide and pro-retinol good for sensitive skin?

Hexapeptide and strong retinoids should be kept apart in the same routine because combined stimulation may increase irritation, which is a concern for sensitive skin. You can alternate usage by applying the retinoid in the PM and peptides in the AM.

Research on hexapeptide and pro-retinol

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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