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Hexapeptide and mandelic acid

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Hexapeptide and mandelic acid: keep them apart

Keep them apart

Use them at different times of day by applying mandelic acid in the morning and hexapeptide at night, because acid breaks down the peptide. The acid is too harsh and ruins the peptide, making it stop working for your skin. You can fix this by using them in separate routines or waiting longer between them.

Hexapeptide products

Mandelic acid products

Questions and answers

Can you use hexapeptide and mandelic acid together?

Keep hexapeptide and mandelic acid apart in your routine because the low pH of mandelic acid destabilizes peptide bonds and reduces their bioactivity. Use them in separate steps or routines, such as applying mandelic acid in the morning and hexapeptide in the evening.

Which goes first, hexapeptide or mandelic acid?

Keep hexapeptide and mandelic acid apart by using them in separate steps or routines, such as AM and PM, because the low pH of mandelic acid can destabilize hexapeptide. Using them together may reduce the bioactivity of the peptide.

Are hexapeptide and mandelic acid good for sensitive skin?

Hexapeptide and mandelic acid should be kept apart in your routine because the acidic environment of mandelic acid destabilizes peptides. Use mandelic acid in a separate step or routine, such as AM and PM separation, especially for sensitive skin.

Research on hexapeptide and mandelic acid

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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