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Hexapeptide and hyaluronic acid

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Hexapeptide and hyaluronic acid: work well together

Work well together

Apply the hyaluronic acid first to hydrate the skin, and then follow with the hexapeptide. Hyaluronic acid draws in moisture to create a plump base, which helps the hexapeptide firm the skin more effectively. You do not need to change anything since this combination is gentle.

Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled studyThe efficiency of humectants as skin moisturizers in the presence of oil

Hexapeptide products

Hyaluronic acid products

Questions and answers

Can you use hexapeptide and hyaluronic acid together?

Yes, hexapeptide and hyaluronic acid work well together to provide a synergistic improvement in elasticity and hydration. Combining them helps increase hydration and supports barrier integrity.

Annals of Dermatology, 2019

Which goes first, hexapeptide or hyaluronic acid?

Hexapeptide and hyaluronic acid work well together, and you can layer a hydrating hyaluronic acid serum beneath your peptide product. Combining them provides enhanced hydration and helps trigger collagen synthesis for all skin types, especially dry and mature skin.

Annals of Dermatology, 2019

Are hexapeptide and hyaluronic acid good for sensitive skin?

Hexapeptide and hyaluronic acid work well together to enhance hydration and support skin barrier integrity. Layering a hydrating hyaluronic acid serum beneath a peptide product helps improve elasticity and firmness for all skin types.

Annals of Dermatology, 2019International Journal of Biological Macromolecules, 2018

Research on hexapeptide and hyaluronic acid

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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