Hexapeptide

What to combine hexapeptide with

Ingredient	Together	How to use them
Panthenol	Works well	Use them together in the same routine, applying panthenol first to calm the skin and hexapeptide second to firm it. Hexapeptide and panthenol
Green tea	Works well	Use green tea and hexapeptide together in the same routine, applying green tea first and hexapeptide right after, because they help each other work better. Hexapeptide and green tea
Ceramide-building complex	Works well	Use them together in the same routine, applying the ceramide complex first and the hexapeptide right after, because the lipids help your skin absorb the peptide better. Hexapeptide and ceramide-building complex
Glycerin	Works well	Use them together by applying your glycerin hydrating serum first, followed by your hexapeptide product, because hydration helps the peptides absorb better. Hexapeptide and glycerin
Coenzyme Q10	Works well	Use them together by applying coenzyme Q10 first and hexapeptide second, because they work well as a team. Hexapeptide and coenzyme q10
Vitamin E	Works well	Use them together in the same routine, applying the vitamin E product first and the hexapeptide product second, because they help each other work better. Hexapeptide and vitamin E
Bakuchiol	Works well	Use them together in the same routine, applying your bakuchiol product first and then your hexapeptide cream. Hexapeptide and bakuchiol
Silk amino acids	Works well	Use them together in the same routine, applying the silk amino acids first and the hexapeptide right after, because they boost each other. Hexapeptide and silk amino acids
Arginine	Works well	Use them together, applying the peptide first and the amino acid right after, because they help each other repair the skin barrier. Hexapeptide and arginine
Liposome	Works well	Use them together in the same routine, applying the liposome product first and the hexapeptide product right after. Hexapeptide and liposome
Taurine	Works well	Use them together in the same routine, because they support healthy skin and moisture balance. Hexapeptide and taurine
Hyaluronic acid	Works well	Apply the hyaluronic acid first to hydrate the skin, and then follow with the hexapeptide. Hexapeptide and hyaluronic acid
Microcapsule	Works well	Use them together in the same routine, applying the microcapsules before the hexapeptide to help it absorb better. Hexapeptide and microcapsule
Cholesterol	Works well	Use them together in the same routine, applying the peptide product first and the cholesterol cream right after, because lipids help peptides soak in better. Hexapeptide and cholesterol
Phytosphingosine	Works well	Use them together by applying the hexapeptide first and the phytosphingosine right after, because lipids help the peptide absorb better. Hexapeptide and phytosphingosine
Betaine	Works well	Use them together by applying the betaine hydrating serum first, followed by the hexapeptide, because moisture helps peptides work better. Hexapeptide and betaine
Phytosterol	Works well	Use them together in the same routine, applying the peptide serum first and following it with the phytosterol cream. Hexapeptide and phytosterol
Beta-sitosterol	Works well	Use them together in the same routine, applying the hexapeptide first and the beta-sitosterol right after to lock it in. Hexapeptide and beta-sitosterol
Squalene	Works well	Use them together by applying the peptide serum first, because the squalene oil helps it sink in and locks in moisture. Hexapeptide and squalene
Tri-ceramide complex	Works well	Use them together in the same routine, applying the tri-ceramide complex first and the hexapeptide right after, because the lipids help the peptides absorb better. Hexapeptide and tri-ceramide complex
GABA	Works well	Use them together in the same routine, because they team up to hydrate and repair your skin. Hexapeptide and GABA
Theanine	Works well	Use them together in the same routine, because they help each other keep your skin hydrated and firm. Hexapeptide and theanine
Vitamin C	Depends	Apply vitamin C in the morning and hexapeptide at night because mixing them reduces their effectiveness. Hexapeptide and vitamin C
Retinol	Depends	Use them at different times of day with peptides in the morning and retinol at night, because combining them all at once can irritate skin. Hexapeptide and retinol
Niacinamide	Depends	Use them together in the same routine, because niacinamide helps strengthen the skin while the peptide supports anti-aging and firmness. Hexapeptide and niacinamide
Adapalene	Keep apart	Use them at different times of day by applying your peptide product in the morning and adapalene at night to avoid skin irritation. Hexapeptide and adapalene
Glycolic acid	Keep apart	Use them at different times of day, applying glycolic acid in the morning and hexapeptide at night, because acid ruins peptide strength. Hexapeptide and glycolic acid
Benzoyl peroxide	Keep apart	Apply them at different times of day, using benzoyl peroxide in the morning and hexapeptide at night, because heat and certain harsh conditions can break down the peptide. Hexapeptide and benzoyl peroxide
Azelaic acid	Keep apart	Use azelaic acid and hexapeptide at different times of day, applying the acid in the morning and the peptide at night, because mixing them together makes the peptide lose its power. Hexapeptide and azelaic acid
AHA blend glycolic and citric acids	Keep apart	Use them at different times of day by applying the acid in the morning and the hexapeptide at night, because the acid breaks down the peptide. Hexapeptide and aha blend glycolic and citric acids
Salicylic acid	Keep apart	Use them at different times of day, applying salicylic acid first and hexapeptide later, because acid destroys peptide power. Hexapeptide and salicylic acid
Tretinoin	Keep apart	Use them at different times of day by applying your peptide product in the morning and tretinoin at night to prevent skin irritation. Hexapeptide and tretinoin
Vitamin A	Keep apart	Use them at different times of day, applying vitamin A at night and hexapeptide in the morning, to prevent skin irritation. Hexapeptide and vitamin A
Pro-retinol	Keep apart	Use them at different times of day by applying your pro-retinol at night and your hexapeptide in the morning to avoid extra skin irritation. Hexapeptide and pro-retinol
Retinal	Keep apart	Use them at different times of day, applying retinal at night and hexapeptide in the morning, to prevent skin irritation. Hexapeptide and retinal
Copper	Keep apart	Use them on alternate nights, applying copper first and hexapeptide later, because they can cancel each other out. Hexapeptide and copper
Magnesium	Keep apart	Use them at different times of day, applying the peptide serum in the morning and the magnesium at night, because they cancel each other out. Hexapeptide and magnesium
Lactic acid	Keep apart	Apply lactic acid and hexapeptide at different times of day because acids break down peptides and ruin their anti-aging power. Hexapeptide and lactic acid
Mandelic acid	Keep apart	Use them at different times of day by applying mandelic acid in the morning and hexapeptide at night, because acid breaks down the peptide. Hexapeptide and mandelic acid
Retinoid blend	Keep apart	Use them at different times of day, applying the retinoid at night and the hexapeptide in the morning. Hexapeptide and retinoid blend
Superoxide dismutase	Keep apart	Use them at different times of day, applying hexapeptide in the morning and superoxide dismutase at night, because their active structures clash. Hexapeptide and superoxide dismutase
Polyvinyl alcohol	Keep apart	Use them at different times of day, applying the peptide first, because they clash and cancel each other out. Hexapeptide and polyvinyl alcohol
Zinc	Keep apart	Use them at different times of day, applying the peptide first and the zinc later, because mixing them makes the peptide less effective. Hexapeptide and zinc
Zinc sulfate	Keep apart	Use them at different times of day, applying the peptide first and the zinc later, because they cancel each other out when mixed. Hexapeptide and zinc sulfate
Bleach	Keep apart	Use them at different times of day, applying the peptide first and the bleach later, because mixing them destroys the peptide benefits. Hexapeptide and bleach
Granactive retinoid	Keep apart	Use them at different times of day, applying the peptide serum in the morning and the retinoid at night, to avoid extra skin irritation. Hexapeptide and granactive retinoid
Hydroxypinacolone retinoate	Keep apart	Use them at different times of day by applying your peptide product in the morning and your hydroxypinacolone retinoate at night. Hexapeptide and hydroxypinacolone retinoate
Potassium hydroxide	Keep apart	Use them at different times of day, applying the peptide first and the potassium hydroxide later, because they clash in chemical balance. Hexapeptide and potassium hydroxide
Citric acid	Keep apart	Use them at different times of day, applying the acid first and the peptide later, because mixing them makes the peptide lose its power. Hexapeptide and citric acid
Isopropyl alcohol	Keep apart	Use them at different times of day, applying the hexapeptide first, because alcohol damages the peptide. Hexapeptide and isopropyl alcohol
Behenyl alcohol	Keep apart	Use them at different times of day, applying the peptide first, because alcohol makes the peptide less effective. Hexapeptide and behenyl alcohol
Protease	Keep apart	Use them at different times of day, applying the peptide product in the morning and the protease at night, because they cancel each other out. Hexapeptide and protease
Baking soda	Keep apart	Use them at different times of day by applying your peptide product first, because baking soda stops peptides from working properly. Hexapeptide and baking soda

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

Research on hexapeptide

• The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study

  Hexapeptide · American Journal of Clinical Dermatology, 2013

• A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face

  Hexapeptide · Journal of Cosmetic Dermatology, 2017

• Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin

  Hexapeptide · Annals of Dermatology, 2019

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.