Estée Lauder Nutritious Melting Soft Creme/Mask for mature skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction.

  Journal of Cosmetic Dermatology, 2024

• Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery.

  Journal of Cosmetic Dermatology, 2023

• Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir.

  Frontiers in Microbiology, 2020

• Phenolic-rich pomegranate peel extract formulated into a serum and mask showed significantly better facial skin lightening efficacy than placebo in 30 volunteers over 28 days.

  Planta Medica, 2020

• Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• A topical microemulsion containing Punica granatum extract significantly reduced skin erythema and melanin compared to a placebo in healthy Asian subjects over 12 weeks.

  Postepy Dermatologii I Alergologii, 2014

Ingredients

Water, Heptyl Undecylenate, Butylene Glycol, Glycerin, Polyglyceryl-6 Distearate, Trimethylolpropane Tricaprylate Tricaprate, Butyrospermum Parkii Butter Shea Butter, Cetyl Alcohol, Niacinamide, Laminaria Digitata Extract, Porphyridium Cruentum Extract, Lactobacillus Ferment, Hydrolyzed Rice Extract, Punica Granatum Extract, Zinc Pca, Dipotassium Glycyrrhizate, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, Caffeine, Narcissus Tazetta Bulb Extract, Cucumis Sativus Fruit Extract, Jojoba Esters, Helianthus Annuus Seed Extract Sunflower Seed Extract, Hordeum Vulgare Extract, Sucrose, Saccharide Isomerate, Tocopheryl Acetate, Sodium Phytate, Sodium Citrate, Citric Acid, Pentylene Glycol, Sodium Dehydroacetate, Propylene Glycol Dicaprate, Xanthan Gum, Ethylhexylglycerin, Tocopherol, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.