Perricone MD Cold Plasma Plus+ for sensitive skin
Ascorbic Acid Ester
Copper Tripeptide
Acetyl Hexapeptide-8
Omega 3
Glycolic AcidAverage
- AverageNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate skin treatment for your normal skin, as Tetrahexyldecyl Ascorbate and Acetyl Hexapeptide-8 work to brighten and minimize fine lines, though concentrations are not optimal for your specific concerns.
- Glycerin and Sodium Hyaluronate provide general hydration and soothing benefits, which are supportive but not directly targeted at your redness and irritation.
- The product is safe for your sensitive skin, with no risks of irritation due to the absence of harsh ingredients.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.2Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.
Highlights
Unpleasant scent Mostly Mentioned
- “smells like fish”
- “scent is off-putting”
- “earthy and funky smell”
- “hard to get past the smell”
Improves skin texture Often Mentioned
- “smooths my skin overnight”
- “minimized my large pores”
- “texture is not grainy anymore”
- “skin feels fantastic”
High price tag Often Mentioned
- “very expensive product”
- “not worth the money”
- “price is steep”
- “waiting for a sale”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “sinks right in”
- “lightweight and not sticky”
- “non-greasy finish”
Increases radiance Sometimes Noted
- “saw more radiance”
- “brightening dark spots”
- “skin looks youthful”
- “helps with dullness”
Reduces fine lines Sometimes Noted
- “softens crow's feet”
- “lines appear diminished”
- “helps with wrinkles”
- “skin looks plumper”
Packaging issues Rarely Noted
- “jar is unsanitary”
- “pump stopped working”
- “hard to get product out”
- “prefer a bottle”
Skin irritation Rarely Noted
- “caused redness and burning”
- “broke me out”
- “too strong for sensitive skin”
- “caused dry patches”
Sources: lovi.care, ulta.com, perriconemd.com, amazon.com, sephora.co.uk, lovelyskin.com, and more
Questions and answers
How well does Cold Plasma Plus+ work for sensitive skin?
Perricone MD Cold Plasma Plus+ works as a moderate treatment for sensitive skin, helping to brighten and smooth fine lines while providing general hydration and soothing benefits. Although it is safe and unlikely to cause irritation, a product for this skin needs ingredients like niacinamide or snail secretion filtrate to properly target redness and irritation.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
Which ingredients make this treatment a good fit for sensitive skin?
Glycerin and Sodium Hyaluronate make this treatment a fit by providing general hydration and soothing benefits to calm the skin. This skin type needs ingredients like niacinamide and soothing plant extracts to directly target redness and irritation.
What does Ascorbic Acid do for sensitive skin?
Ascorbic Acid helps improve skin elasticity and calms redness in reactive and sensitive skin when used properly. Studies show it is generally well-tolerated and provides safe anti-aging benefits for delicate skin types.
What does Copper Tripeptide do for sensitive skin?
Copper Tripeptide helps calm sensitive skin by reducing inflammation and supporting skin regeneration. This ingredient is unlikely to cause irritation and may improve overall skin firmness and comfort.
International Journal of Molecular Sciences, 2018BioMed Research International, 2015
Where does this treatment go in a skincare routine for sensitive skin?
This treatment goes in your evening routine, placed after your toner and before your moisturizer. It works for your sensitive skin, though this skin type generally does better with a product that avoids exfoliating acids and focuses instead on gentle hydrators and calming ingredients.
Can I use this treatment with niacinamide, and in what order?
You can use this treatment alongside niacinamide by applying niacinamide first and following with this product once it absorbs. This approach helps keep your sensitive skin calm while layering active ingredients safely. To better fit sensitive skin, a treatment of this type needs soothing ingredients like centella asiatica or green tea extract to reduce redness and irritation.
How often should I use this treatment?
You can use this treatment in the evening a few times a week, as sensitive skin does well when new active products are introduced gradually. This gentle approach helps your skin stay calm and smooth while lowering the likelihood of any sudden irritation.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
Can this treatment clog pores, cause breakouts or purging for sensitive skin?
This treatment is unlikely to clog pores or cause breakouts for sensitive skin, as it has a very low risk of skin irritation. To properly care for sensitive skin, a product of this type needs soothing ingredients like glycerin and sodium hyaluronate to keep the skin calm and hydrated without causing trouble.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016
Ingredients
Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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