Olay Regenerist Regenerating Serum for combination skin
Niacinamide
Palmitoyl Pentapeptide-4
Glycerin
Tocopheryl Acetate
Allantoin
High
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
A great choice for combination skin; a few serums fit it even better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Cosmetic Science, 2005
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin as niacinamide helps regulate oil production in your oily areas while glycerin provides essential hydration for your drier zones.
- The serum offers excellent skin regeneration, smoothing texture and minimizing fine lines with ingredients like palmitoyl pentapeptide-4.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.5Overall rating based on 1.0k+ reviewsBased on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, making it ideal for layering. Many report softer, hydrated skin and a reduction in fine lines, contributing to a smoother appearance. A small number of users experienced breakouts or found the texture sticky.
Highlights
Effective hydration Mostly Mentioned
- “My skin feels so hydrated and plump.”
- “It's very moisturizing without being heavy.”
- “Leaves my skin feeling soft.”
Silky texture Mostly Mentioned
- “Absorbs so quickly!”
- “Feels like silk on my skin.”
- “Doesn't feel greasy at all.”
Convenient packaging Sometimes Noted
- “The pump dispenser is hygienic and easy to use.”
- “Great for travel, doesn't leak.”
- “Easy to get the right amount of product.”
Fragrance-free option Sometimes Noted
- “No strong scent, which is great for my sensitive skin.”
- “I didn't react to the fragrance.”
- “Good for people who dislike perfumed products.”
Visible results Sometimes Noted
- “I've noticed a difference in my fine lines.”
- “My skin looks brighter and healthier.”
- “It gives a nice glow.”
Ingredient concerns Rarely Noted
- “Contains parabens which I try to avoid.”
- “Has silicones that feel heavy.”
- “Worried about the preservatives.”
Packaging flaws Rarely Noted
- “The pump stopped working after a week.”
- “Couldn't get all the product out.”
- “The bottle is hard to use up.”
Skin reactions Rarely Noted
- “Broke me out in cystic acne.”
- “Caused a rash all over my face.”
- “I got small bumps after using it.”
Texture issues Rarely Noted
- “Felt sticky on my skin.”
- “Pilled when I applied makeup over it.”
- “Left a tacky residue.”
Value for money Rarely Noted
- “It's quite expensive for the amount you get.”
- “I went through the bottle too fast.”
- “Not great value for a drugstore serum.”
Sources: lovi.care, walmart.com, target.com, ulta.com, faceserum.com, youtube.com, and more
Questions and answers
What makes Olay Regenerist Regenerating Serum a great fit for combination skin?
Olay Regenerist Regenerating Serum is a great fit because niacinamide helps balance oil in your shiny zones while glycerin brings much-needed moisture to your dry spots. It also smooths texture and softens fine lines safely without any harsh ingredients that might upset your skin.
International Journal of Cosmetic Science, 2005Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for combination skin?
Niacinamide helps regulate oil in your oily zones while glycerin provides needed hydration for your drier areas. Palmitoyl pentapeptide-4 further supports this by smoothing texture and minimizing fine lines.
International Journal of Cosmetic Science, 2005Clinical, Cosmetic and Investigational Dermatology, 2017
What does Niacinamide do for combination skin?
Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
What does Palmitoyl Pentapeptide-4 do for combination skin?
Palmitoyl Pentapeptide-4 helps smooth fine lines and wrinkles on combination skin by boosting collagen production. It is unlikely to cause irritation and may improve skin texture with regular use.
Where does this serum go in a skincare routine for combination skin?
This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to provide essential hydration and smoothing benefits, and following with your retinol once it absorbs. This approach is unlikely to cause irritation for your combination skin since the formula contains no harsh or prohibited ingredients.
How often should I use this serum?
You can use this serum in your evening routine for simplicity and extra safety around sun exposure, or as part of a weekly care routine. It is a great fit for your combination skin because niacinamide helps balance oil in oily areas while glycerin hydrates drier zones, and it is very safe and unlikely to cause irritation.
International Journal of Cosmetic Science, 2005Clinical, Cosmetic and Investigational Dermatology, 2017
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is a great fit for your combination skin because niacinamide helps balance your oily areas while glycerin provides lightweight moisture for your dry zones, and it is unlikely to cause breakouts or irritation due to its very safe ingredient makeup.
Clinical, Cosmetic and Investigational Dermatology, 2017Cureus, 2026
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.
International Journal of Cosmetic Science, 2005Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks.
Cureus, 2026A functionalized dendrimer nanocarrier delivers active ingredients into the dermis and enhances collagen production in human dermal fibroblasts by co-delivering all-trans retinol and palmitoyl pentapeptide-4.
Acta Biomaterialia, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Dimethicone, Glycerin, Niacinamide, Dimethicone Crosspolymer, Polymethylsilsesquioxane, Panthenol, Polyethylene, Palmitoyl Pentapeptide-4, Sodium Peg-7 Olive Carboxylate Oil, Tocopheryl Acetate, Allantoin, Camellia Sinensis Leaf Extract, Dimethiconol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dmdm Hydantoin, Iodopropynyl Butylcarbamate, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, C13-14 Isoparaffin, Aminomethyl Propanol, Laureth-4, Laureth-7, Disodium Edta
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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