iS Clinical Reparative Moisture Emulsion for sensitive skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.

  European Journal of Pharmaceutics and Biopharmaceutics, 2016

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Co-culturing mesenchymal stem cells and human keratinocytes on nylon66 electrospun scaffolds loaded with Beta vulgaris extract enhanced cell proliferation and promoted epithelial differentiation compared to mono-cell culturing.

  Materials Science & Engineering. C, Materials for Biological Applications, 2017

• An aqueous extract of Beta vulgaris reduced lipid accumulation and reactive oxygen species in human HaCaT keratinocyte cells treated with palmitic/oleic acids or hydrogen peroxide.

  International Journal of Molecular Sciences, 2026

• Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls.

  International Journal of Cosmetic Science, 2004

• Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.

  European Journal of Pharmaceutics and Biopharmaceutics, 2007

• Superoxide dismutase 3 suppressed Propionibacterium acnes-induced skin inflammation by inhibiting the TLR2/p38/NF-κB axis and NLRP3 inflammasome activation in vitro and in vivo.

  Scientific Reports, 2018

Why other moisturizers fit sensitive skin better

• Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine.

  Skin Research and Technology, 2003

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

Ingredients

Water, Sodium Hyaluronate, Glycerin, Squalane, Caprylic Capric Triglyceride, Beta Vulgaris Root Extract, Haberlea Rhodopensis Leaf Extract, Yeast Extract, Tocopherol, Panthenyl Triacetate, Ethyl Linoleate, Butylene Glycol, Acetyl Tyrosine, Proline, Hydrolyzed Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Tripeptide-1, Lecithin, Xanthan Gum, Carbomer, Triethanolamine, Glycosaminoglycans, Urea, Glucose, Guanidine Hcl, Cetearyl Alcohol, Ceteareth-20, Dimethicone, Dipalmitoyl Hydroxyproline, Cyclomethicone, Polysorbate 40, Superoxide Dismutase, Pvp, Panthenol, Retinyl Palmitate, Tocopheryl Acetate, Ascorbyl Palmitate, Pantothenic Acid, Ethylbisiminomethylguaiacol Manganese Chloride, 1,2-Hexanediol, Caprylyl Glycol, Disodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.