NEOCUTIS Bio Serum Firm for oily skin
Rejuvenating Growth Factor
Peptides
Sodium Hyaluronate
Acetyl Glucosamine
Aminopropyl Ascorbyl Phosphate
Average
- HighOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your oily skin, this serum contains Aminopropyl Ascorbyl Phosphate and Glycerin to provide antioxidant benefits and hydration, supporting overall skin health.
- The inclusion of Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate offers moderate firming effects, promoting skin elasticity and reducing the appearance of fine lines.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Glycerin and Sodium Hyaluronate.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.6Overall rating based on 500+ reviewsUsers frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.
Highlights
High price Mostly Mentioned
- “Pricey for amount”
- “Little on the pricey side”
- “Expensive growth factor serum”
Hydrating and Plumping Often Mentioned
- “Very hydrating”
- “Plumps my skin as advertised”
- “Big drink of water for my dry skin”
Improves Skin Texture Often Mentioned
- “Saw improved smoothness”
- “Skin texture has improved”
- “Makes my skin feel very smooth”
Reduces Fine Lines Often Mentioned
- “Diminishes the appearance of fine lines”
- “Softens wrinkles”
- “Less visible/apparent right away”
Fast Results Sometimes Noted
- “Saw results immediately”
- “Results in less than a week”
- “Fast results!”
Gentle on Skin Sometimes Noted
- “No issues with sensitive skin”
- “Does not cause irritation”
- “Soothing sensation”
Irritation/Reactions Rarely Noted
- “Burns when I apply it”
- “Acne came back”
- “Insaaane allergic reaction”
Lack of Results Rarely Noted
- “Not seen any difference”
- “Just garden variety humectants”
- “Results are temporary”
Product Pilling Rarely Noted
- “Causes pilling when I put anything on top”
- “Pilling”
Sources: lovi.care, lovelyskin.com, neocutis.com, dermavenue.com, reddit.com, youtube.com, and more
Questions and answers
How well does Neocutis Bio Serum Firm work for oily skin?
Neocutis Bio Serum Firm works moderately well for oily skin, providing hydration and firming benefits without causing irritation. However, a product of this type needs ingredients like niacinamide, zinc PCA, or ferulic acid to effectively control excess oil and manage shine for this skin type.
Journal of Cosmetic Dermatology, 2026Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for oily skin?
Aminopropyl Ascorbyl Phosphate and Glycerin make this serum a good fit for oily skin by providing antioxidant benefits and keeping the face hydrated without causing irritation. To be an even better fit for this skin type, a treatment needs ingredients like niacinamide and zinc PCA to control shine and manage excess oil.
What does Growth Factor do for oily skin?
Growth factor helps balance and repair oily skin while supporting a smooth and calm texture. This type of skin needs lightweight hydrators and soothing ingredients that manage excess oil without clogging pores.
What do Peptides do for oily skin?
Peptides help support skin health and may improve the look of oily skin, but this type of skin needs formulas with ingredients that balance oil production and keep pores clear.
Advanced Science, 2025International Journal of Molecular Sciences, 2025
Where does it go in a skincare routine for oily skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. Treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following it with your retinol. Because this product lacks harsh ingredients and contains soothing components like glycerin and sodium hyaluronate, it is unlikely to irritate your skin when paired with a retinoid.
How often should I use it?
You can use this treatment in the evening as part of your routine. Oily skin needs lighter serums and gel hydrators with niacinamide and salicylic acid to stay fresh and balanced.
Can this serum clog pores, cause breakouts or purging for oily skin?
This serum is unlikely to cause breakouts or clog pores on oily skin, as it is free of harsh ingredients and contains soothing components like glycerin and sodium hyaluronate. Oily skin often benefits from lightweight hydrators and antioxidants such as aminopropyl ascorbyl phosphate and glycerin to support skin health without feeling heavy.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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