Cetaphil Sheer Mineral Sunscreen SPF 50 for combination skin

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Questions and answers

What the research says

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Microfine titanium dioxide does not penetrate human skin when formulated in an oil-in-water emulsion with the pigment dispersed in the aqueous phase, compared to oily dispersions and liposomal encapsulation which allow deeper skin penetration.

  International Journal of Cosmetic Science, 2000

• Replacing microsized titanium dioxide and zinc oxide with nanoparticles in sunscreens eliminates opaqueness and alters UV protection balance while inducing (photo)cyto- and genotoxicity and penetrating viable skin layers during long-term exposures.

  Nanotechnology, Science and Applications, 2011

• Microfine zinc oxide and titanium dioxide do not penetrate the stratum corneum of porcine skin in vitro, indicating that their use in sunscreens does not pose a health risk from internal exposure.

  Toxicology in Vitro, 2006

• Hyaluronic acid-grafted titanium dioxide nanoparticles increased SPF from 13.3 to 19.1 while demonstrating low photocatalytic activity, exceptional thermal stability with >95% SPF retention, enhanced moisturization with >80% hydration retention, and minimal cytotoxicity with 88.5% cell viability in HaCaT keratinocytes compared to unmodified nanoparticles.

  International Journal of Biological Macromolecules, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Colloidal oat increased the growth rate, metabolism, and lactic acid production of Staphylococcus epidermidis compared to Staphylococcus aureus in vitro, matching clinical increases in lactic acid on dry skin after 6 weeks of lotion use.

  Clinical, Cosmetic and Investigational Dermatology, 2021

• A dermocosmetic product containing oat plantlet sap and Garcinia mangostana extract reduced retentional and inflammatory acne lesions by 21% and 35% respectively after 2 months in 54 subjects with mild-to-moderate acne.

  Journal of the European Academy of Dermatology and Venereology, 2024

Ingredients

Titanium Dioxide, Zinc Oxide, Alumina, Arachidyl Alcohol, Arachidyl Glucoside, Ascorbic Acid, Avena Sativa Kernel Extract Oat Kernel Extract, Beeswax, Behenyl Alcohol, Benzyl Alcohol, Bisabolol, Butylene Glycol, Butyloctyl Salicylate, Calendula Officinalis Flower Extract, Camellia Sinensis Leaf Extract, Carbomer, Ceramide Ap, Ceramide Eop, Ceramide Np, Cetyl Dimethicone, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Cholesterol, Dimethicone, Dimethicone Peg-8 Laurate, Dipotassium Glycyrrhizate, Disodium Edta, Ethylhexylglycerin, Glycerin, Glyceryl Stearate, Hydrated Silica, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Maltodextrin, Methicone, Panthenol, Pantothenic Acid, Peg-100 Stearate, Peg-8, Phytosphingosine, Polyaminopropyl Biguanide, Polymethyl Methacrylate, Polysorbate 60, Potassium Sorbate, Propylene Glycol, Sodium Lauroyl Lactylate, Stearic Acid, Styrene Acrylates Copolymer, Tocopheryl Acetate Vitamin E, Triethoxycaprylylsilane, Trimethylsiloxysilicate, Trisiloxane, Vp Eicosene Copolymer, Water, Xanthan Gum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.