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Alcohol · Journal of Occupational Medicine and Toxicology, 2008Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors
Peppermint extract · Brain, 2004Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Niacinamide · Antioxidants, 2021Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Camellia sinensis extract · Carcinogenesis, 2001Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation
Ecklonia cava extract · Toxicology in Vitro, 2009Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Alcohol · International Journal of Toxicology, 2001Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments
Rice bran oil · Journal of Nanobiotechnology, 2011Cosmetic benefits of astaxanthin on humans subjects
Astaxanthin, Astaxanthin powder · Acta Biochimica Polonica, 2012Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid, Low molecular hyaluronic acid · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol, Panthenol vitamin b5, Panthenol vb5 · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf juice, Aloe barbadensis leaf extract · Iranian Journal of Medical Sciences, 2019Caffeine's mechanisms of action and its cosmetic use
Caffeine · Skin Pharmacology and Physiology, 2013Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract · Journal of the American Academy of Dermatology, 2001Improvement of naturally aged skin with vitamin A (retinol)
Retinol · Archives of Dermatology, 2007Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome
Probiotics · International Journal of Medical Sciences, 2021Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Ascorbyl palmitate ascorbic acid, Ascorbic acid magnesium ascorbyl phosphate · Experimental Dermatology, 2003Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin
Probiotics · Experimental Dermatology, 2019Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol, Tocopherol vitamin e, Ascorbic acid, Vitamins c, Vitamin e tocopherol · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Ferulic acid · Journal of Cosmetic Dermatology, 2008Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics
Water-soluble collagen · Dermatology Practical & Conceptual, 2022The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree leaf extract · Indian Journal of Dermatology, Venereology and Leprology, 2007Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005Sunscreen and prevention of skin aging: a randomized trial
Spf 30, Naturally sourced sunscreen · Annals of Internal Medicine, 2013Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives
Tetrahexyldecyl ascorbate ascorbic acid · Journal of Cosmetic Dermatology, 2012Tea tree oil reduces histamine-induced skin inflammation
Melaleuca alternifolia tree leaf extract · The British Journal of Dermatology, 2002Antioxidant, Wound Healing Potential and In Silico Assessment of Naringin, Eicosane and Octacosane
Grapefruit fruit extract · Molecules, 2023Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol · The British Journal of Dermatology, 2019Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside, Ascorbic acid magnesium ascorbyl phosphate · Journal of Periodontology, 2009Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin
Scutellaria baicalensis root extract · Journal of Drugs in Dermatology, 2014Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells
Sanguisorba officinalis root extract · Phytomedicine, 2015Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng root extract · Journal of Ginseng Research, 2017Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
Grapefruit fruit extract · PloS One, 2016Ferulic acid photoprotective properties in association with UV filters: multifunctional sunscreen with improved SPF and UVA-PF
Sunscreen filters · Journal of Photochemistry and Photobiology. B, Biology, 2018Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract, Madecassoside, Asiaticoside · Indian Journal of Pharmaceutical Sciences, 2016Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
Titanium dioxide · International Journal of Cosmetic Science, 2000Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract · Journal of Ethnopharmacology, 2007Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Cica complex, Centella asiatica extract · Pharmaceutics, 2024The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway
Houttuynia cordata extract · Plants, 2021Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1
Tremella fuciformis sporocarp extract mushroom extract · Molecular Medicine Reports, 2017Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin
Polypodium leucotomos leaf extract · Photodermatology, Photoimmunology & Photomedicine, 1997Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis extract, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis polysaccharides leaf, Aloe barbadensis, Aloe barbadensis leaf juice powder, Melaleuca alternifolia tree leaf extract, Propolis extract, Aloe barbadensis juice · Clinical Pharmacology, 2018Use of Collagen in Cosmetic Products
Water-soluble collagen · Current Issues in Molecular Biology, 2024Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study
Ceramide iii b · International Journal of Pharmaceutics, 2006Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013Antioxidant properties evaluation of topical astaxanthin formulations as anti-aging products
Hydrolyzed algae extract, Algae extract · Journal of Cosmetic Dermatology, 2019Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramides, Ceramide · Scientific Reports, 2022Effect of Camellia japonica oil on human type I procollagen production and skin barrier function
Camellia japonica seed oil · Journal of Ethnopharmacology, 2007Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A
Glycyrrhiza inflata root extract · Journal of the European Academy of Dermatology and Venereology, 2016Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase
Zingiber officinale · Archives of Dermatological Research, 2008Hyperoside and Quercitrin in Houttuynia cordata Extract Attenuate UVB-Induced Human Keratinocyte Cell Damage and Oxidative Stress via Modulation of MAPKs and Akt Signaling Pathway
Houttuynia cordata extract · Antioxidants, 2022Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid, Vitamins c · Clinical Oral Investigations, 2021Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol · Acta Dermato-venereologica, 2017Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np, Ceramide-3 · International Journal of Dermatology, 2008Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10
Ecklonia cava extract · Evidence-based Complementary and Alternative Medicine, 2018Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol, Tocopherol vitamin e, Ascorbic acid, Vitamins c, Ferulic acid · Journal of Cosmetic Dermatology, 2020Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders
Lecithin · Clinical, Cosmetic and Investigational Dermatology, 2015Clinical Studies on Topical Curcumin
Curcuma longa root extract · Skin Pharmacology and Physiology, 2023Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study
Retinyl palmitate · International Journal of Nanomedicine, 2021Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair
Dipotassium glycyrrhizate · Acta Biomaterialia, 2022Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo
Glycyrrhiza glabra licorice · Experimental Dermatology, 2015A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations
Arbutin · Journal of Cosmetic Dermatology, 2015Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos
Polypodium leucotomos leaf extract · Photodermatology, Photoimmunology & Photomedicine, 1996Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
Argania spinosa kernel oil · International Journal of Nanomedicine, 2014Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies
Moringa oleifera seed extract · Antioxidants, 2022Cosmeceutical properties of levan produced by Zymomonas mobilis
Fructan · Journal of Cosmetic Science, 2005The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle
Alpha lipoic acid · European Journal of Pharmaceutics and Biopharmaceutics, 2014Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects
Rosa gallica flower extract · Journal of Medicinal Food, 2020The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside, Madecassic acid · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Asiaticoside · Journal of Alternative and Complementary Medicine, 2020The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel
Ascorbyl palmitate · Die Pharmazie, 2005The Herbal Bitter Drug Gentiana lutea Modulates Lipid Synthesis in Human Keratinocytes In Vitro and In Vivo
Gentiana lutea root extract · International Journal of Molecular Sciences, 2017Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol)
Isobutylamido thiazolyl resorcinol · International Journal of Cosmetic Science, 2021Cytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types
Hydrogenated lecithin · International Journal of Pharmaceutics, 2019Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007In vivo photoprotective effects of cosmetic formulations containing UV filters, vitamins, Ginkgo biloba and red algae extracts
Hydrolyzed algae extract · Journal of Photochemistry and Photobiology. B, Biology, 2015Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment
Calamine · European Journal of Pharmaceutics and Biopharmaceutics, 2016Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties
Algae extract · Journal of Cosmetic Science, 2002Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Panthenol vitamin b5, Dexpanthenol, Panthenol vb5 · The Journal of Dermatological Treatment, 2017Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate vitamin e acetate, Tocopheryl acetate · Urologia Internationalis, 2019A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Carnitine, Glycyrrhiza inflata root extract · BioMed Research International, 2020Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage
Spirulina energy essence, Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde
Peppermint extract · The Journal of Pain, 2016Ascorbic Acid Treatments as Effective and Safe Anti-Aging Therapies for Sensitive Skin
Ascorbyl palmitate ascorbic acid · Antioxidants, 2024Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid · Journal of Cosmetic Dermatology, 2019Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant
Caffeine · Frontiers in Physiology, 2019Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel
Carnitine · The Journal of Dermatological Treatment, 2016Functional photostability and cutaneous compatibility of bioactive UVA sun care products
Glucosylrutin · Journal of Photochemistry and Photobiology. B, Biology, 2015Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility
Glucosylrutin · Skin Research and Technology, 2016Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
Hydrogenated lecithin, Lecithin · International Journal of Pharmaceutics, 2020A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree leaf extract · Archives of Dermatological Research, 2022A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser
Spf 30, Naturally sourced sunscreen, Broad spectrum spf 30 · Clinical, Cosmetic and Investigational Dermatology, 2022Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Panthenol vitamin b5, Allantoin, Dexpanthenol, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Mexoryl SX: a broad absorption UVA filter protects human skin from the effects of repeated suberythemal doses of UVA
Cell-ox shield technology · Journal of Photochemistry and Photobiology. B, Biology, 1998Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results
Cell-ox shield technology · Photodermatology, Photoimmunology & Photomedicine, 2008Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate, Tetrahexadecyl ascorbate, Ascorbyl tetraisopalmitate · Photochemistry and Photobiology, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate, Tetrahexadecyl ascorbate, Ascorbyl tetraisopalmitate · Journal of Cosmetic Dermatology, 2019High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel leaf extract, Witch hazel leaf water · Phytochemistry, 2001The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycyrrhiza inflata root extract · Clinical, Cosmetic and Investigational Dermatology, 2019Preparation, Characterization, and Biological Activities of Topical Anti-Aging Ingredients in a Citrus junos Callus Extract
Citrus junos fruit extract · Molecules, 2017Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica extract, Madecassoside, Centella asiatica root extract · Molecules, 2023Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris
Triethyl citrate · The British Journal of Dermatology, 2007Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium)
Chrysanthemum parthenium flower leaf stem juice · Inflammopharmacology, 2009A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne
Carnitine · Journal of the European Academy of Dermatology and Venereology, 2013In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract · International Journal of Cosmetic Science, 2020Allergy to oxidized limonene and linalool is frequent in the U.K
Citrus aurantium dulcis oil · The British Journal of Dermatology, 2014Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Saccharomyces rice ferment filtrate · Journal of Clinical Medicine, 2021Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide, Mineral sunscreen, Calamine, Uncoated clear zinc oxide · Journal of Controlled Release, 2025Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies
Carnosine, Helichrysum italicum extract · Dermatology and Therapy, 2020Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol
Butyrospermum parkii oil shea oil · Pharmaceutics, 2020The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
Asiaticoside · International Journal of Nanomedicine, 2021Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes
Tremella fuciformis sporocarp extract, Tremella fuciformis sporocarp extract mushroom extract · In Vivo, 2022Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Moringa oleifera seed extract · Drug Delivery, 2022Polyglycerol Ester-Based Low Energy Nanoemulsions with Red Raspberry Seed Oil and Fruit Extracts: Formulation Development toward Effective In Vitro/In Vivo Bioperformance
Rubus idaeus seed oil raspberry seed oil · Nanomaterials, 2021Genistein protects against ultraviolet B-induced wrinkling and photoinflammation in in vitro and in vivo models
Soy isoflavones · Genes & Nutrition, 2022A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np, Ceramide iii b, Ceramide-3, 3 essential ceramides · Skin Pharmacology and Physiology, 2022Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
Hexylresorcinol · Journal of Drugs in Dermatology, 2016Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Persea gratissima oil avocado oil · Journal of Cosmetic Dermatology, 2020Evaluation of the protection of sunscreen products against long wavelength ultraviolet A1 and visible light-induced biological effects
Iron oxides · Photodermatology, Photoimmunology & Photomedicine, 2024Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil · Forschende Komplementarmedizin, 2012In Vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications
Aloe ferox leaf extract · Pharmacognosy Magazine, 2014Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide
Hexylresorcinol · International Journal of Cosmetic Science, 2022Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e · Journal of Cosmetic Dermatology, 2022Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies
Arctostaphylos uva-ursi leaf extract · Heliyon, 2023Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Rice extract, Sunscreen filters · Pharmaceuticals, 2023A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them
Ceramide ng, Myristoyl palmitoyl oxostearamide arachamide mea · Archives of Dermatological Research, 2017Enhancement of comedogenic substances by ultraviolet radiation
Theobroma cacao seed butter · The British Journal of Dermatology, 1978Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Cassia alata leaf extract, Grapefruit fruit extract · Frontiers in Chemistry, 2024Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial
Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin
Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Protective Effects of Fermented Houttuynia cordata Against UVA and H2O2-Induced Oxidative Stress in Human Skin Keratinocytes
Houttuynia cordata extract · Applied Biochemistry and Biotechnology, 2023Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies
Tocopheryl glucoside · Clinical, Cosmetic and Investigational Dermatology, 2017Guide to tinted sunscreens in skin of color
Iron oxides · International Journal of Dermatology, 2024Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study
Arbutin · Journal of Cosmetic Science, 2020Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract, Camellia sinensis leaf water · Clinical, Cosmetic and Investigational Dermatology, 2019Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010Is benzyl alcohol a significant contact sensitizer?
Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract, Rosemary leaf extract · Pharmaceutics, 2021Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System
Tetrahexyldecyl ascorbate ascorbic acid · Pharmaceutics, 2023Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Ex vivo penetration analysis and anti-inflammatory efficacy of the association of ferulic acid and UV filters
Sunscreen filters · European Journal of Pharmaceutical Sciences, 2021Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters
Ectoin · Journal of Cosmetic Dermatology, 2024Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2021In vivo and in vitro evaluation of octyl methoxycinnamate liposomes
Ethylhexyl methoxycinnamate, Octinoxate · International Journal of Nanomedicine, 2013Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study
Beta-glucan · Journal of Cosmetic Dermatology, 2021Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract · Planta Medica, 2019An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
Willow bark extract · Journal of Cosmetic Dermatology, 2010Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression
Chrysanthemum parthenium flower leaf stem juice · Archives of Dermatological Research, 2008Comedogenicity in rabbit: some cosmetic ingredients/vehicles
Isopropyl myristate · Cutaneous and Ocular Toxicology, 2007Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate, Ascorbyl palmitate, Ascorbic acid ester · Drug Research, 2017Skin improvement and stability of Echinacea purpurea dermatological formulations
Echinacea purpurea extract · International Journal of Cosmetic Science, 2010Comparative benefit of two thermal spring waters after photodynamic therapy procedure
Prebiotic thermal water · Journal of Cosmetic Dermatology, 2007Film-Forming Properties of Topical Formulations for Skin and Hair: In Vivo and In Vitro Studies Using Biophysical and Imaging Techniques
Blue algae extract · AAPS PharmSciTech, 2022Understanding Solar Skin Elastosis-Cause and Treatment
Witch hazel leaf water · Journal of Cosmetic Science, 2018Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging
Pentylene glycol · International Journal of Molecular Sciences, 2018Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine · Molecules, 2024Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
Ethyl ascorbyl ether, 3-o-ethyl ascorbic acid, 2-o-ethyl ascorbic acid · Polymers, 2023Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study
Alteromonas extract ferment, Alteromonas extract ferment abyssine extract ferment · Clinical, Cosmetic and Investigational Dermatology, 2017Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema
Morinda citrifolia extract · Journal of Natural Medicines, 2009Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Royal jelly extract · Journal of Cosmetic Dermatology, 2022Solid lipid nanoparticles bearing oxybenzone: in-vitro and in-vivo evaluation
Oxybenzone, Oxybenzone-free formula · Journal of Microencapsulation, 2010A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Astaxanthin, Astaxanthin powder · Journal of Cosmetic Dermatology, 2023Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin
Coconut fruit extract · Food and Chemical Toxicology, 2017Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers
Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019Interactions between UV filters and active substances in emulsion: Effect on microstructure, physicochemical and in-vivo properties
Uv filters · International Journal of Pharmaceutics, 2018Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol
Sorbitol · Journal of Cosmetic Science, 2013Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids
Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Skin Improvement with Antioxidant Effect of Yuja (Citrus junos) Peel Fractions: Wrinkles, Moisturizing, and Whitening
Citrus junos fruit extract · Antioxidants, 2022Evaluation of liposomal and conventional formulations of octyl methoxycinnamate on human percutaneous absorption using the stripping method
Octinoxate · Journal of Cosmetic Science, 2008Comparison of methods for assessing photoprotection against ultraviolet A in vivo
Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters
Butyl methoxydibenzoylmethane, Oxybenzone-free formula · International Journal of Pharmaceutics, 2019Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rose oil flower, Rosa damascena extract · Acta Pharmaceutica, 2013Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Carica papaya fruit extract · Giornale Italiano Di Dermatologia E Venereologia, 2015Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study
Isopropyl myristate · International Journal of Pharmaceutics, 2019Unique natural exopolysaccharides for biomimetic protective effect against urban pollution
Patented alguronic acid · Journal of Cosmetic Science, 2017Ellagitannins from Rosa roxburghii suppress poly(I:C)-induced IL-8 production in human keratinocytes
Rosa roxburghii fruit extract · Journal of Natural Medicines, 2021Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis
Royal jelly extract · European Journal of Dermatology, 2011Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis
Tetrahexadecyl ascorbate · Journal of Cosmetic Dermatology, 2020Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract · Journal of Clinical Medicine, 2023Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025UVA-UVB photoprotective activity of topical formulations containing Morinda citrifolia extract
Morinda citrifolia extract · BioMed Research International, 2014Axillary hyperhidrosis. Local treatment with aluminium-chloride hexahydrate 25% in absolute ethanol with and without supplementary treatment with triethanolamine
Triethanolamine · Acta Dermato-venereologica, 1988Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation
Arbutin · Biomaterials Science, 2023Effects of Moringa oleifera Seed Oil on Cultured Human Sebocytes In Vitro and Comparison with Other Oil Types
Moringa oleifera seed oil · International Journal of Molecular Sciences, 2023Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin
Phytosphingosine · International Journal of Cosmetic Science, 2007Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide, Mineral sunscreen · Biomedicines, 2025Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial
Portulaca oleracea extract · BMC Oral Health, 2023Efficacy of ethyl ascorbyl ether-containing cosmetic cream on blue light-induced skin changes
Ethyl ascorbyl ether · Journal of Cosmetic Dermatology, 2022Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters
Octocrylene, Rosemary leaf extract, Rosmarinus officinalis oil leaf rosemary oil leaf · Antioxidants, 2025A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter · Journal of Cosmetic Dermatology, 2022Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Cranberry fruit extract · Skin Pharmacology and Physiology, 2007Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed oil, Moringa oleifera seed extract · Polymers, 2022The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021Inhibitory Effects of Parachlorella Beijerinckii Extracts on the Formation of Advanced Glycation End Products and Glycative Stress-Induced Inflammation in an In Vitro Skin Dermis-Like Model
Parachlorella beijerinckii exopolysaccharides · Evidence-based Complementary and Alternative Medicine, 2022Rates of allergic sensitization and irritation to oxybenzone-containing sunscreen products: a quantitative meta-analysis of 64 exaggerated use studies
Helioplex technology, Helioplex, Benzophenone-3 · Photodermatology, Photoimmunology & Photomedicine, 2008Algae extract protection effect on oxidized protein level in human stratum corneum
Hydrolyzed algae extract, Algae extract · Annals of the New York Academy of Sciences, 2004HYVIA™: A novel, topical chia seed extract that improves skin hydration
Salvia hispanica seed extract · Journal of Cosmetic Dermatology, 2020Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021Nanowire-based squalene oleogel repairs skin photoaging
Squalane · Journal of Nanobiotechnology, 2025Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Anti-Photoaging Effects of Upcycled Citrus junos Seed Anionic Peptides on Ultraviolet-Radiation-Induced Skin Aging in a Reconstructed Skin Model
Citrus junos fruit extract · International Journal of Molecular Sciences, 2024TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection
Avobenzone, Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance
Hexylresorcinol · Archives of Dermatological Research, 2023The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate · Journal of Cosmetic Dermatology, 2013Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Panthenol vitamin b5, Dexpanthenol, Panthenol vb5 · Journal of Cosmetic Dermatology, 2025Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol · Molecules, 2021Beta vulgaris-derived exosome-like nanovesicles mitigate photoaging by attenuating oxidative stress and promoting collagen biosynthesis
Beta vulgaris · Colloids and Surfaces. B, Biointerfaces, 2026Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy
Willow bark extract · Nanomaterials, 2022Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling
Watermelon extract · AAPS PharmSciTech, 2020Protective Mechanism of Rosa roxburghii Tratt Fermentation Broth against Ultraviolet-A-Induced Photoaging of Human Embryonic Skin Fibroblasts
Rosa roxburghii fruit extract · Antioxidants, 2024Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid, 2-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications
Astaxanthin, Astaxanthin powder · International Journal of Biological Macromolecules, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Moisturizing potentials of ascorbyl palmitate and calcium ascorbate in various topical formulations
Ascorbyl palmitate · International Journal of Cosmetic Science, 2004(+)-Erythro-Δ8'-7S,8R-Dihydroxy-3,3',5'-Trimethoxy-8-O-4'-Neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt
Nutmeg extract · Molecules, 2020Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-κB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth
Houttuynia cordata extract · Foods, 2024Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate · Experimental Dermatology, 2012Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation
Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study
Theanine · Journal of Clinical Medicine, 2022Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study
Algae extract · Scientific Reports, 2025Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides
Glucosyl ceramide · International Journal of Molecular Sciences, 2022X-ray diffraction study on ordered, disordered and reconstituted intercellular lipid lamellar structure in stratum corneum
Stearic acid · Biophysical Chemistry, 2001Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin
Helichrysum italicum extract · Journal of Ethnopharmacology, 2023Investigation of Morinda citrifolia Activities through Pinoresinol and α-EG Related Gene Expression
Morinda citrifolia extract · Plants, 2022Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer
Saccharomyces rice ferment filtrate · Journal of Clinical Medicine, 2022Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging
Snail secretion filtrate · The Journal of Clinical and Aesthetic Dermatology, 2020Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate vitamin e, Tocopheryl acetate, Tocopheryl acetate vitamin e acetate · Scientific Reports, 2025Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate · Journal of Cosmetic Dermatology, 2024Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study
Jojoba esters · Journal of Cosmetic Dermatology, 2008Clinical study of a spray containing birch juice for repairing sensitive skin
Betula alba juice · Archives of Dermatological Research, 2023Dirt-binding particles consisting of hydrogenated castor oil beads constitute a nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination in a three-step programme of occupational skin protection
Hydrogenated castor oil · The British Journal of Dermatology, 2010Pectin-like polysaccharide extracted from Cucumis melo pulp: physicochemical, antioxidant, and skin hydration efficacy
Cucumis melo fruit extract · Natural Product Research, 2026Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Prebiotic thermal water, Thermal spring water, Aqua dolomiae extract · Journal of the European Academy of Dermatology and Venereology, 2020Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023In vitro, ex vivo and clinical approaches to evaluate the potential effect of Gentiana lutea extract on skin
Gentiana lutea root extract · International Journal of Cosmetic Science, 2023Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin
Scutellaria baicalensis root extract · Journal of Cosmetic Dermatology, 2025Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
2-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
3 essential ceramides · Journal of Cosmetic Dermatology, 2025Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability
2-o-ethyl ascorbic acid · Journal of Liposome Research, 2025Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties
Tocopheryl glucoside · International Journal of Cosmetic Science, 2021Visible Light Protection Strategies for Diverse Populations
Iron oxides · Dermatology and Therapy, 2026Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo-controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants
Tasmannia lanceolata leaf extract fruit · Journal of Cosmetic Dermatology, 2021Upcycled Cocoa Pod Husk: A Sustainable Source of Phenol and Polyphenol Ingredients for Skin Hydration, Whitening, and Anti-Aging
Theobroma cacao seed extract · Life, 2025Study of the soothing effects of troxerutin in alleviating skin sensitivity
Troxerutin · Journal of Cosmetic Dermatology, 2024Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid · Journal of Drugs in Dermatology, 2013Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid
Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate vitamin e, Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021Facial disbiosis and UV filters
Ethylhexyl salicylate, Octinoxate, Ethylhexyl methoxycinnamate, Octocrylene · Archives of Dermatological Research, 2024Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin
Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Ascorbyl glucoside · International Journal of Molecular Sciences, 2024Cedarwood Oil as Complementary Treatment in Refractory Acne
Juniperus mexicana oil · Journal of Alternative and Complementary Medicine, 2016The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study
Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024[Topical application of vitamins, phytosterols and ceramides. Protection against increased expression of interstital collagenase and reduced collagen-I expression after single exposure to UVA irradiation]
Phytosterols · Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, und Verwandte Gebiete, 2008A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects
Arginine · Journal of Cosmetic Dermatology, 2020Preliminary evaluation of a comprehensive skincare regimen for enhancing skin health following advanced optimal pulse technology (AOPT) treatment
Ergothioneine · International Journal of Cosmetic Science, 2025Investigating the Effects of a Manuka Honey, Royal Jelly, and Bee Venom-Derived Face Serum on Skin Health and Signs of Aging
Royal jelly extract · Cureus, 2025Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control
Retinyl palmitate · Journal of Clinical Medicine, 2026Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics
Camellia sinensis leaf water · International Journal of Cosmetic Science, 2025Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study
Saccharomyces rice ferment filtrate · Journal of Clinical Medicine, 2023Evolution of lipid composition in skin treated with blackcurrant seed oil
Ribes nigrum seed oil · International Journal of Cosmetic Science, 1988Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers
Dimethicone · Military Medicine, 2024Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study
Thermal spring water · The Medical Journal of Malaysia, 2024Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter shea butter, Argania spinosa kernel oil, Butyrospermum parkii butter extract shea butter extract, Saccharide isomerate, Butyrospermum parkii oil shea oil · Lasers in Medical Science, 2025Retrospective Review of Dermal Safety Studies of Organic Sunscreens
Ethylhexyl salicylate, Homosalate, Octisalate · Journal of Drugs in Dermatology, 2025Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu
Copper tripeptide-1 · Skin Research and Technology, 2026Salicylic acid peel incorporating triethyl citrate and ethyl linoleate in the treatment of moderate acne: a new therapeutic approach
Triethyl citrate · Dermatologic Surgery, 2013Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026In vitro analysis of immunoprotective effects of topical sunscreens
Ethylhexyl triazone, Ethylhexyltriazone · Toxicology in Vitro, 1994Effects of an ultraviolet B radiation absorber on photocarcinogenesis in hairless albino mice
Ethylhexyl triazone · Skin Pharmacology and Physiology, 2009Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis
Ergothioneine · Frontiers in Nutrition, 2026A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023An Aqueous Extract of Beta vulgaris subsp. Vulgaris Beetroot Group Reduces Lipid Accumulation in Human Keratinocyte Cells
Beta vulgaris · International Journal of Molecular Sciences, 2026Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1, Scutellaria baicalensis root extract · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
Ceramide iii b · Skin Pharmacology and Physiology, 2026Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients
Lactobacillus ferment · International Journal of Cosmetic Science, 2026Iontophoretic Delivery of Hyaluronic Acid Nanogel-Loaded Fermented Rice Extract Mitigates Skin Glycation
Rice extract · International Journal of Nanomedicine, 2025Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026The harnessing potential of carboxymethyl beta glucan: A driver of skin repair
Sodium carboxymethyl betaglucan · International Journal of Cosmetic Science, 2026Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
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