NATURIUM Niacinamide Serum 12% Plus Zinc 2% for mature skin
Niacinamide
Zinc Pca
Sodium Hyaluronate
Tocopheryl Acetate Vitamin E
GlycerinAverage
- HighNormal Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent pore cleansing and oil control for your normal skin, as niacinamide and zinc PCA work to decongest pores and mattify oily areas.
- While sodium hyaluronate and glycerin provide general hydration, these ingredients are mostly supportive and do not directly address your primary concern of wrinkles and fine lines.
- The product is safe for your normal skin, featuring soothing ingredients like niacinamide and glycerin with no harsh or prohibited components.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 12.5k+ reviewsBased on a very large amount of data, this serum is highly effective for oily and acne-prone skin, with users frequently reporting minimized pores, controlled oil production, and smoother skin texture. Some users, particularly those with sensitive skin, experience irritation, stinging, or breakouts due to the high concentration of niacinamide. A small number of users also noted a sticky residue or saw no visible results.
Highlights
Controls oil Mostly Mentioned
- “great at controlling sebum production”
- “controls the oiliness”
- “reduces oiliness”
Lightweight, absorbs fast Often Mentioned
- “absorbs really fast”
- “lightweight and absorbs quickly”
- “not sticky or heavy on the skin”
Minimizes pores Often Mentioned
- “pores look more minimized on and around my nose”
- “pores look smaller which is really nice”
- “visually refine the complexion”
Smooths texture Often Mentioned
- “skin definitely looks more smooth”
- “texture of this serum is really silky”
- “smooths appearance of fine lines”
Brightens tone Sometimes Noted
- “acne scars have lightened”
- “helps to brighten my skin”
- “even out skin tone”
Causes breakouts Sometimes Noted
- “broke me out so bad”
- “caused breakouts for my skin”
- “bumps are going away”
Too strong Sometimes Noted
- “too strong for my sensitive skin”
- “high concentration... cause irritation”
- “harsh for some people's skin”
Causes irritation Rarely Noted
- “stinging and itching”
- “burning sensation”
- “reaction to it”
No results Rarely Noted
- “haven't seen any improvement”
- “don't necessarily see the difference”
- “didn't do anything for me”
Sticky residue Rarely Noted
- “left such a sticky layer”
- “sticky residue”
- “tacky finish”
Sources: lovi.care, naturium.com, target.com, ulta.com, influenster.com, skinsort.com, and more
Questions and answers
How well does Naturium Niacinamide 12% Plus Zinc 2% work for mature skin?
This serum works for mature skin by helping clear pores and balance oil, but other products fit this skin better because they target wrinkles and fine lines more directly. Mature skin needs products with powerful antioxidants, peptides, and skin-repairing ingredients that improve elasticity and smooth out lines.
Journal of Cosmetic Dermatology, 2021Scientific Reports, 2024
Which ingredients make this serum a good fit for mature skin?
Niacinamide helps improve skin aging signs, while sodium hyaluronate and glycerin provide general hydration. Mature skin needs products with powerful anti-aging ingredients, potent antioxidants, and peptides that specifically target wrinkles, fine lines, and elasticity.
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
What does Zinc PCA do for mature skin?
Zinc PCA is typically used to help balance oil and calm breakouts, so it is not usually targeted toward mature skin. Mature skin generally needs ingredients like retinoids, antioxidants, and hydrating agents to support firmness, smooth fine lines, and keep skin soft.
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after your cleansing toner and before your moisturizer. Mature skin needs treatments with firming peptides, retinoids, or targeted antioxidants to properly smooth fine lines and wrinkles.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying this water-based treatment before your retinol product to help keep your skin calm. This product is safe for your skin, featuring soothing ingredients like niacinamide and glycerin with no harsh or prohibited components.
How often should I use this serum?
This treatment works best in your evening routine, applied once a day. A product of this type needs firming ingredients like retinoids or peptides to truly smooth fine lines on mature skin.
Facial Plastic Surgery, 2014The Journal of Dermatological Treatment, 2005
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum may cause breakouts for mature skin, as some reviewers experience this reaction and the formula includes ingredients that can feel strong or leave a sticky residue. To prevent clogged pores and breakouts, mature skin needs a lightweight treatment that deeply targets fine lines and wrinkles while gently hydrating without heavy or pore-blocking components.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts.
International Journal of Cosmetic Science, 2012Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Why other serums fit mature skin better
Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline.
In Vivo, 2023Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.
Journal of Cosmetic Dermatology, 2020
Ingredients
Water, Niacinamide, Propanediol, Glycerin, Zinc Pca, Polyacrylate Crosspolymer-11, Sodium Hyaluronate, Dimethicone, Caprylyl Glycol, Phenoxyethanol, Xanthan Gum, Potassium Sorbate, Glyceryl Polyacrylate, Tocopheryl Acetate, Hexylene Glycol, Citric Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
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Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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