Clarins Double Serum for sensitive skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical escin promotes angiogenic behavior and enhances adenosine-induced perfusion in humans by activating Wnt signaling via Gsk3beta down-regulation.

  Current Issues in Molecular Biology, 2025

• A multiple W/O/W emulsion containing Rosmarinus officinalis L., Avena sativa L., and Linum usitatissimum L. extracts showed no irritant, phototoxic, inflammatory, or allergenic potential in human skin models and patch tests, establishing its safety as a cosmetic base.

  Pharmaceutics, 2021

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties.

  Skin Pharmacology and Physiology, 2023

• Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models.

  Drug Discovery Today, 2017

• A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation.

  Saudi Pharmaceutical Journal, 2024

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Colloidal oat increased the growth rate, metabolism, and lactic acid production of Staphylococcus epidermidis compared to Staphylococcus aureus in vitro, matching clinical increases in lactic acid on dry skin after 6 weeks of lotion use.

  Clinical, Cosmetic and Investigational Dermatology, 2021

• Topical quinoa bioester application upregulated skin barrier proteins and antioxidant enzymes, shifting proteomic profiles to predict lower biological skin ages compared to vehicle-treated skin by median differences of 11 and 16 years for participants under and over 50.

  Communications Biology, 2026

• Quinoa bioester exposure in human reconstructed epidermis tridimensional cell cultures increased the abundance of proteins related to preventing premature aging, homeostasis, tissue regeneration, and protection against ultraviolet radiation and oxidative damage compared to untreated counterparts.

  Scientific Reports, 2020

• Quinoa husk peptide fraction reduces melanin content via Akt signaling and apoptosis pathways in A375 cells and rat skin cells.

  IScience, 2023

• Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.

  Journal of Cosmetic Dermatology, 2023

• Cosmetic eye and facial creams containing palmitoyl peptides, Silybum marianum seed oil, and vitamin E improve facial wrinkles, elasticity, dermal density, and skin tone in healthy volunteers with aged skin after 4 weeks of application compared to pre-application.

  Experimental and Therapeutic Medicine, 2016

• Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.

  Journal of Cutaneous Medicine and Surgery, 2024

Ingredients

Water, Cetearyl Isononanoate, Glycerin, Isononyl Isononanoate, Caprylic Capric Triglyceride, Pentylene Glycol, Ppg-3 Myristyl Ether, Ethylene Propylene Styrene Copolymer, Dipsacus Sylvestris Extract, Butylene Glycol, Parfum, Phenoxyethanol, Propanediol, Tromethamine, Silybum Marianum Seed Oil, Carbomer, Tocopheryl Acetate, Escin, Chenopodium Quinoa Seed Extract, Ethylhexylglycerin, Squalane, Avena Sativa Kernel Extract Oat Kernel Extract, Theobroma Cacao Extract, Butylene Ethylene Styrene Copolymer, Leontopodium Alpinum Extract, Xanthan Gum, Persea Gratissima Oil Avocado Oil, Caramel, Curcuma Longa Root Extract, Salicyloyl Phytosphingosine, Musa Sapientum Fruit Extract, Salicornia Herbacea Extract, Actinidia Chinensis Fruit Extract, Kalanchoe Pinnata Leaf Extract, Sodium Benzoate, Citric Acid, Myrothamnus Flabellifolia Stem Extract Leaf, Disodium Edta, Tocopherol, Lycium Barbarum Fruit Extract, Maltodextrin, Orthosiphon Stamineus Extract, Hedychium Coronarium Root Extract, Mangifera Indica Leaf Extract, Potassium Sorbate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Jania Rubens Extract, Ascorbic Acid, Sodium Citrate, Engelhardtia Chrysolepis Leaf Extract, Ci 14700 Red 4, Callicarpa Japonica Fruit Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.