Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Niacinamide · Antioxidants, 2021Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Egcg epigallocatechin gallate, Camellia sinensis, Camellia sinensis extract · Carcinogenesis, 2001Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Alcohol · International Journal of Toxicology, 2001Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol, Panthenol vitamin b5, Vitamin b5 · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf juice powder, Aloe barbadensis leaf extract, Aloe barbadensis, Aloe barbadensis leaf juice · Iranian Journal of Medical Sciences, 2019Caffeine's mechanisms of action and its cosmetic use
Caffeine · Skin Pharmacology and Physiology, 2013Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract · Journal of the American Academy of Dermatology, 2001A systematic review of Calendula officinalis extract for wound healing
Calendula officinalis flower extract · Wound Repair and Regeneration, 2019Improvement of naturally aged skin with vitamin A (retinol)
Retinol, Retinol vitamin a, Pro-retinol a · Archives of Dermatology, 2007Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis
Passiflora edulis fruit extract · Journal of Agricultural and Food Chemistry, 2010Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Ascorbic acid sodium ascorbyl phosphate, Sodium ascorbyl phosphate ascorbic acid · Experimental Dermatology, 2003Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol, Tocopherol vitamin e, Vitamin e tocopherol · Journal of Cosmetic Dermatology, 2020A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation
Ferulic acid · Journal of the American Academy of Dermatology, 2008Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin
Ferulic acid, Phloretin · Journal of Cosmetic Dermatology, 2008Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics
Collagen powder, Collagen, E-collagen · Dermatology Practical & Conceptual, 2022Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Palmitoyl pentapeptide-4, Amino-peptide · International Journal of Cosmetic Science, 2005Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol, Retinol vitamin a, Pro-retinol a · International Journal of Cosmetic Science, 2017Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles
Gold, 24k gold · The Journal of Investigative Dermatology, 2015Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris
Phytosphingosine · International Journal of Cosmetic Science, 2007Protecting skin photoaging by NF-kappaB inhibitor
Magnolia officinalis bark extract · Current Drug Metabolism, 2010Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care
Ubiquinone · BioFactors, 2008Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside, Ascorbic acid sodium ascorbyl phosphate · Journal of Periodontology, 2009Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol, Retinol vitamin a, Bakuchiol, Pro-retinol a · The British Journal of Dermatology, 2019Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes
Phenylethyl resorcinol · Asian Journal of Pharmaceutical Sciences, 2018Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng root extract · Journal of Ginseng Research, 2017Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women
Oxidized glutathione, Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage
Chrysin · Journal of Agricultural and Food Chemistry, 2011Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract · Journal of Ethnopharmacology, 2007Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract, Madecassoside, Asiaticoside, Madecassic acid, Centella asiatica stem extract flower leaf · Indian Journal of Pharmaceutical Sciences, 2016Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
Titanium dioxide · International Journal of Cosmetic Science, 2000The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract · Pharmaceutics, 2024Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane, Squalene · Scientific Reports, 2020Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts
Ilex paraguariensis leaf extract · Scientific Reports, 2021Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects
Ubiquinone · BioFactors, 2015Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf juice powder, Aloe barbadensis leaf juice, Aloe barbadensis leaf extract, Aloe barbadensis · Clinical Pharmacology, 2018Use of Collagen in Cosmetic Products
Collagen · Current Issues in Molecular Biology, 2024Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
Camellia sinensis · The Journal of Investigative Dermatology, 2019Antioxidant properties evaluation of topical astaxanthin formulations as anti-aging products
Algae extract · Journal of Cosmetic Dermatology, 2019Effect of Camellia japonica oil on human type I procollagen production and skin barrier function
Camellia japonica seed oil · Journal of Ethnopharmacology, 2007Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramide, Ceramides, Ceramide blend · Scientific Reports, 2022Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A
Glycyrrhiza inflata root extract · Journal of the European Academy of Dermatology and Venereology, 2016Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin
Glyceryl glucoside, Jericho rose jelly · Skin Pharmacology and Physiology, 2012Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications
Phenylethyl resorcinol · BioMed Research International, 2017Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid · Clinical Oral Investigations, 2021Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np, Eop · International Journal of Dermatology, 2008Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation
Hesperidin methyl chalcone · Photochemical & Photobiological Sciences, 2016Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol · Acta Dermato-venereologica, 2017Anti-acne vulgaris effects of chlorogenic acid by anti-inflammatory activity and lipogenesis inhibition
Ilex paraguariensis leaf extract · Experimental Dermatology, 2021Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid, Ferulic acid, Tocopherol, Tocopherol vitamin e, Vitamin e tocopherol · Journal of Cosmetic Dermatology, 2020Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study
Retinyl palmitate · International Journal of Nanomedicine, 2021Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo
Glycyrrhiza glabra root extract licorice root extract, Licorice, Licorice root extract · Experimental Dermatology, 2015Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Resveratrol · Molecules, 2023Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration
Argania spinosa kernel oil · International Journal of Nanomedicine, 2014Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal
Nelumbo nucifera flower extract · International Journal of Pharmaceutics, 2022Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)
Narcissus tazetta bulb extract · Daru, 2018The moisturizing effects of glycolipid biosurfactants, mannosylerythritol lipids, on human skin
Glycolipids · Journal of Oleo Science, 2012The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside, Madecassic acid · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Asiaticoside, Madecassic acid · Journal of Alternative and Complementary Medicine, 2020α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract
Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling
Leontopodium alpinum meristem cell culture · Genes, 2020Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells
Leontopodium alpinum meristem cell culture · Mediators of Inflammation, 2012Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol)
Isobutylamido thiazolyl resorcinol · International Journal of Cosmetic Science, 2021Encapsulation and controlled release of retinol from silicone particles for topical delivery
Advanced retinol, Pro-retinol a · Journal of Controlled Release, 2018Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study
Isobutylamido thiazolyl resorcinol · International Journal of Cosmetic Science, 2020Cytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types
Hydrogenated lecithin · International Journal of Pharmaceutics, 2019Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides
Palmitoyl pentapeptide-4 · Advanced Science, 2025Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
Acetyl glucosamine · The British Journal of Dermatology, 2010The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties
Algae extract · Journal of Cosmetic Science, 2002A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen
Retinyl propionate · The British Journal of Dermatology, 2010Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study
Sodium ascorbyl phosphate ascorbic acid · Dermatologic Therapy, 2022A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Panthenol vitamin b5, Vitamin b5 · The Journal of Dermatological Treatment, 2017Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate · Urologia Internationalis, 2019Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB
Magnolia officinalis bark extract · European Journal of Pharmacology, 2007A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage
Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid · Journal of Cosmetic Dermatology, 2019Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Palmitoyl grape seed extract · International Journal of Cosmetic Science, 2015Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties
Dunaliella salina extract · Marine Drugs, 2022Efficacy of Green Tea Extract for Treatment of Dry Eye and Meibomian Gland Dysfunction; A Double-blind Randomized Controlled Clinical Trial Study
Camellia sinensis leaf extract · Journal of Clinical and Diagnostic Research, 2017Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide
Glyceryl glucoside, Jericho rose jelly · The Journal of Clinical and Aesthetic Dermatology, 2012Fermented pomegranate extracts protect against oxidative stress and aging of skin
Punica granatum extract · Journal of Cosmetic Dermatology, 2022Alpha hydroxyacids modulate stratum corneum barrier function
Tartaric acid · The British Journal of Dermatology, 1997Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone
Hydroxydecyl ubiquinone · Journal of Cosmetic Dermatology, 2005Effects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin
Hydrogenated lecithin · International Journal of Pharmaceutics, 2020Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Panthenol, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate, Power 5c vitamin complex, Ascorbyl tetraisopalmitate · Photochemistry and Photobiology, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate · Journal of Cosmetic Dermatology, 2019Evaluation of anti-acne properties of phloretin in vitro and in vivo
Phloretin · International Journal of Cosmetic Science, 2016Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin
Panax ginseng root extract · Journal of Ginseng Research, 2021The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019Topical glutathione amino acid precursors protect skin against environmental and oxidative stress
Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts
Snail secretion filtrate · Molecules, 2023Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 · Annals of Dermatology, 2019Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways
Tremella fuciformis sporocarp extract · Journal of Cosmetic Dermatology, 2021Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica extract, Centella asiatica leaf extract, Madecassoside, Centella asiatica, Centella asiatica stem extract flower leaf · Molecules, 2023The effects of tea extracts on proinflammatory signaling
Black tea extract · BMC Medicine, 2006A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Galactomyces ferment filtrate · Journal of Clinical Medicine, 2021Efficacy of olive leaf extract-containing cream for facial rejuvenation: A pilot study
Olea europaea leaf extract olive leaf extract · Journal of Cosmetic Dermatology, 2020In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract · International Journal of Cosmetic Science, 2020The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023Photothermal therapy using gold nanoparticles for acne in Asian patients: A preliminary study
Colloidal gold · Dermatologic Therapy, 2021Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide · Journal of Controlled Release, 2025Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Moringa oleifera seed extract · Drug Delivery, 2022Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies
Helichrysum italicum extract, Helichrysum italicum oil flower, Helichrysum italicum essential oil · Dermatology and Therapy, 2020The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial
Hesperidin · Journal of Cosmetic Dermatology, 2021A dermocosmetic regimen is able to mitigate skin sensitivity induced by a retinoid-based fixed combination treatment for acne: Results of a randomized clinical trial
Retinoid complex · Journal of Cosmetic Dermatology, 2024High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
Asiaticoside · International Journal of Nanomedicine, 2021A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np · Skin Pharmacology and Physiology, 2022Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Palmitoyl oligopeptide, Matrixyl 3000, Palmitoyl tetrapeptide-3 · Journal of Cosmetic Dermatology, 2015Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil · Forschende Komplementarmedizin, 2012Hormesis-based anti-aging products: a case study of a novel cosmetic
Hydrolyzed ginseng saponins · Dose-response, 2013Anti-inflammation and anti-apoptosis effects of pearl extract gel on UVB irradiation HaCaT cells
Pearl extract · Bio-medical Materials and Engineering, 2015Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol
Hexylresorcinol · Journal of Drugs in Dermatology, 2016Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Avocado oil · Journal of Cosmetic Dermatology, 2020A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Ginkgo biloba leaf extract, Ginkgo biloba extract, Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin
Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester, Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e · Journal of Cosmetic Dermatology, 2022Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019Exotic Vegetable Oils for Cosmetic O/W Nanoemulsions: In Vivo Evaluation
Lanolin · Molecules, 2016Exploring the antioxidant potentiality of two food by-products into a topical cream: stability, in vitro and in vivo evaluation
Medicago sativa extract · Drug Development and Industrial Pharmacy, 2016Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin
Terminalia arjuna extract · Skin Pharmacology and Physiology, 2014Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors
Rose extract, Rosa centifolia flower extract · Molecules, 2020Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Ilex paraguariensis extract · Frontiers in Chemistry, 2024Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle
Polyethylene · Dermatologic Surgery, 2008Safety and efficacy of Sclerocarya birrea (A.Rich.) Hochst (Marula) oil: A clinical perspective
Sclerocarya birrea seed oil oil, Sclerocarya birrea seed butter, Sclerocarya birrea seed oil · Journal of Ethnopharmacology, 2015Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin
Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides
Chlorella protothecoides · Food and Chemical Toxicology, 2013Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)
Sodium laureth sulfate · Food and Chemical Toxicology, 2001Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid, Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2021Photothermal therapy using gold nanoparticles and a long-pulsed 755-nm alexandrite laser to treat facial photoaging in Asian skin: A prospective clinical trial
Colloidal gold, Gold extract · Lasers in Surgery and Medicine, 2022Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf water, Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System
Tetrahexyldecyl ascorbate ascorbic acid · Pharmaceutics, 2023The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-8, Tripeptide-10 · Journal of Cosmetic Dermatology, 2017Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract · Pharmaceutics, 2021Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging
Acetyl zingerone · Journal of Cosmetic Dermatology, 2021Well-aging: A new strategy for skin homeostasis under multi-stressed conditions
Tephrosia purpurea seed extract · Journal of Cosmetic Dermatology, 2020Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization
Kojic dipalmitate · Journal of Cosmetic Dermatology, 2022Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study
Beta-glucan · Journal of Cosmetic Dermatology, 2021Development of Sponge Microspicule Cream as a Transdermal Delivery System for Protein and Growth Factors from Deer Antler Velvet Extract
Velvet extract · Biological & Pharmaceutical Bulletin, 2019Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas
Super peptide concentrate, 8 peptide blend · Polymers, 2022Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract · Planta Medica, 2019Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging
Narcissus tazetta bulb extract · International Journal of Molecular Sciences, 2018Comparative benefit of two thermal spring waters after photodynamic therapy procedure
Avène thermal spring water, La roche-posay thermal spring water · Journal of Cosmetic Dermatology, 2007Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings
Camellia sinensis extract · Mini Reviews in Medicinal Chemistry, 2025A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
Terminalia ferdinandiana · Dermatologic Therapy, 2020Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate · Drug Research, 2017Spirulina, Palmaria Palmata, Cichorium Intybus, and Medicago Sativa extracts in cosmetic formulations: an integrated approach of in vitro toxicity and in vivo acceptability studies
Medicago sativa extract · Cutaneous and Ocular Toxicology, 2019The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin
Paeonia albiflora root extract · Journal of Cosmetic Science, 2006Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid · Polymers, 2023Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial
Ferulic acid · The Journal of Dermatological Treatment, 2025Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine · Molecules, 2024Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging
Caviar extract · Marine Drugs, 2022Melanogenesis effects of rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys on UVB-induced human epidermal melanocyte cells
Hydrolyzed rice protein · Food & Function, 2020A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Astaxanthin · Journal of Cosmetic Dermatology, 2023Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol
Sorbitol · Journal of Cosmetic Science, 2013Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers
Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019Final report on the safety assessment of polyethylene
Polyethylene · International Journal of Toxicology, 2007Wax-oil lubricants to reduce the shear between skin and PPE
Paraffinum liquidum mineral oil · Scientific Reports, 2021Neryl acetate, the major component of Corsican Helichrysum italicum essential oil, mediates its biological activities on skin barrier
Helichrysum italicum extract · PloS One, 2023Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids
Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002Protective Effect of the Pearl Extract from Pinctada fucata martensii Dunker on UV-Induced Photoaging in Mice
Pearl extract · Chemistry & Biodiversity, 2022Noninvasive evaluation of the influence of aucubin-containing cosmetic macroemulsion on selected skin parameters
Plantago lanceolata leaf extract · Journal of Cosmetic Dermatology, 2021Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Royal jelly extract · Journal of Cosmetic Dermatology, 2022Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine
Acetyl glucosamine · Advanced Pharmaceutical Bulletin, 2016Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025Comparative efficacy of two anti-aging products containing retinyl palmitate in healthy human volunteers
Palmitic acid · Journal of Cosmetic Dermatology, 2018Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Investigating the Anti-Aging Effects of Caviar Oil on Human Skin
Caviar extract · In Vivo, 2023Treatment of Postinflammatory Hyperpigmentation Following Acne With Microneedling and Panax Ginseng-Derived Exosomes
Panax ginseng root extract · Plastic and Reconstructive Surgery. Global Open, 2025Clinical evidence of the efficacy and safety of a new multi-peptide anti-aging topical eye serum
Multi-peptide blend · Journal of Cosmetic Dermatology, 2023Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract · Journal of Clinical Medicine, 2023Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases
Phragmites communis extract · Archives of Pharmacal Research, 2017Dyspigmentation, skin physiology, and a novel approach to skin lightening
Yeast extract · Journal of Cosmetic Dermatology, 2013Unique natural exopolysaccharides for biomimetic protective effect against urban pollution
Algae exopolysaccharides · Journal of Cosmetic Science, 2017Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin
Copper tripeptide-1 · Archives of Facial Plastic Surgery, 2006Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin
Phytosphingosine · International Journal of Cosmetic Science, 2007Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid
Betaine · Pharmaceutics, 2024Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rosa damascena oil flower · Acta Pharmaceutica, 2013Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate, Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits
Super peptide concentrate · Journal of Cosmetic Dermatology, 2010A horse chestnut extract, which induces contraction forces in fibroblasts, is a potent anti-aging ingredient
Aesculus hippocastanum seed extract · Journal of Cosmetic Science, 2006Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Lavandula angustifolia oil lavender oil · Free Radical Biology & Medicine, 2025Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter, Tapioca starch, African shea butter · Journal of Cosmetic Dermatology, 2022Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed extract · Polymers, 2022A novel sophorolipids extraction method by yeast fermentation process for enhanced skin efficacy
Yeast faex extrait de levure extract · Skin Research and Technology, 2023Algae extract protection effect on oxidized protein level in human stratum corneum
Algae extract · Annals of the New York Academy of Sciences, 2004Hydrolipidic Characteristics and Clinical Efficacy of a Dermocosmetic Formulation for the Improvement of Homeostasis on Oily Mature Skin
Medicago sativa extract · Life, 2022Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract
Palmitoyl grape seed extract · Journal of Cosmetic Dermatology, 2022Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Panthenol vitamin b5, Vitamin b5 · Journal of Cosmetic Dermatology, 2025Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate · Journal of Cosmetic Dermatology, 2013Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin
Palmitoyl pentapeptide-4, Amino-peptide · Acta Biomaterialia, 2025Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate · Experimental Dermatology, 2012Evaluation of the anti-aging effects of Zinc-α2-glycoprotein peptide in clinical and in vitro study
Glycoproteins · Skin Research and Technology, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid, Hydrolyzed sodium hyaluronate · Aesthetic Plastic Surgery, 2026Preparation and characterization of astaxanthin-loaded biodegradable polyhydroxybutyrate (PHB) microbeads for personal care and cosmetic applications
Astaxanthin · International Journal of Biological Macromolecules, 2024Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus extract · International Journal of Biological Macromolecules, 2024Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use
Acetyl glucosamine · Journal of Cosmetic and Laser Therapy, 2019Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol · Molecules, 2021Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging
Snail secretion filtrate · The Journal of Clinical and Aesthetic Dermatology, 2020Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling
Cucumis sativus extract · AAPS PharmSciTech, 2020Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation
Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022Towards a modern approach to traditional use of Helichrysum italicum in dermatological conditions: In vivo testing supercritical extract on artificially irritated skin
Helichrysum italicum extract, Helichrysum italicum oil flower, Helichrysum italicum essential oil · Journal of Ethnopharmacology, 2023Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies
8 peptide blend · Life, 2024Anti-wrinkle properties of Angelica gigas Nakai root extracts using mineral-rich water
Angelica gigas root extract · Journal of Cosmetic Dermatology, 2023Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer
Galactomyces ferment filtrate · Journal of Clinical Medicine, 2022Regenerative Skincare Technologies Derived From Human Fibroblasts: Growth Factors and Exosomes for Transformative Outcomes
Human fibroblast conditioned media · Dermatologic Surgery, 2024A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging
Blueberry extract, Proxylane · Journal of Cosmetic Dermatology, 2025Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate, Ascorbyl tetraisopalmitate · Journal of Cosmetic Dermatology, 2024Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid, Hydrolyzed sodium hyaluronate · Colloids and Surfaces. B, Biointerfaces, 2022Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects
Hippophae rhamnoides extract · Pakistan Journal of Pharmaceutical Sciences, 2014Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Mineral-rich thermal water, Thermal spring water, La roche-posay thermal spring water · Journal of the European Academy of Dermatology and Venereology, 2020Taurine and Polyphenol Complex Repaired Epidermal Keratinocyte Wounds by Regulating IL8 and TIMP2 Expression
Ilex paraguariensis leaf extract · Current Issues in Molecular Biology, 2024Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Preliminary safety and in vivo efficacy of Acmella oleracea extract-loaded glycolipid emulsion serum-Effects on ocular irritation, dermal absorption, and facial skin biophysical and microrelief properties
Glycolipids · International Journal of Cosmetic Science, 2025A method for maintaining the clinical results of 4% hydroquinone and 0.025% tretinoin with a cosmeceutical formulation
Yeast extract · Journal of Drugs in Dermatology, 2015Evaulation of irritation potential of surfactant mixtures
Sodium laureth sulfate · International Journal of Cosmetic Science, 1999Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate, Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Ascorbyl glucoside · International Journal of Molecular Sciences, 2024Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics
Camellia sinensis leaf water, Black tea extract · International Journal of Cosmetic Science, 2025Human Stem Cell-Derived Skin Progenitors Produce Alpha 2-HS Glycoprotein (Fetuin): A Revolutionary Cosmetic Ingredient
Glycoproteins · Journal of Drugs in Dermatology, 2016Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing
Retinyl propionate · International Journal of Cosmetic Science, 2024Lipid extract of microalgae Chlorella vulgaris and Arthrospira platensis as a bioactive ingredient
Chlorella vulgaris extract · Food Science and Technology International = Ciencia Y Tecnologia de Los Alimentos Internacional, 2026Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study
Thermal spring water, Avène thermal spring water, La roche-posay thermal spring water · The Medical Journal of Malaysia, 2024Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers
Dimethicone · Military Medicine, 2024Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study
Snail secretion filtrate · Journal of Cosmetic Dermatology, 2022Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy
Hydroxypropyl tetrahydropyrantriol, Proxylane · Dermatology and Therapy, 2026Skin moisturization by hydrogenated polyisobutene--quantitative and visual evaluation
Hydrogenated polyisobutene · Journal of Cosmetic Science, 2009Darutoside promotes skin wound healing via regulating macrophage polarization
Darutoside · Molecular Immunology, 2025Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation
Retinyl propionate · International Journal of Cosmetic Science, 2017Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging
Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025Preliminary evaluation of a comprehensive skincare regimen for enhancing skin health following advanced optimal pulse technology (AOPT) treatment
Ergothioneine · International Journal of Cosmetic Science, 2025Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora
Paeonia albiflora root extract · International Journal of Molecular Sciences, 2025Investigating the Effects of a Manuka Honey, Royal Jelly, and Bee Venom-Derived Face Serum on Skin Health and Signs of Aging
Royal jelly extract · Cureus, 2025Significant improvement in crow's feet after treatment with Jet-M and a mixed solution of copper-GHK, oligo-hyaluronic acid, rhodiolar extract, tranexamic acid, and β-glucan (GHR formulation)
Tripeptide-1 · Journal of Cosmetic and Laser Therapy, 2016Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study
Galactomyces ferment filtrate · Journal of Clinical Medicine, 2023Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control
Retinyl palmitate · Journal of Clinical Medicine, 2026The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study
Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol · Skin Research and Technology, 2026Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1, Palmitoyl oligopeptide, Tripeptide-1 · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Palmitoyl oligopeptide, Matrixyl 3000 · International Journal of Cosmetic Science, 2026Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter shea butter, Saccharide isomerate, Shea butter, African shea butter · Lasers in Medical Science, 2025Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis
Palmitoyl pentapeptide-4 · Cureus, 2026Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
Camellia sinensis leaf water · Journal of Cosmetic Dermatology, 2023Human skin equivalents are an excellent tool to study the effect of moisturizers on the water distribution in the stratum corneum
Isopropyl isostearate · International Journal of Cosmetic Science, 2012A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation
Escin · Current Issues in Molecular Biology, 2025Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension: new clinical observations
Escin · Angiology, 2004Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu
Copper tripeptide-1 · Skin Research and Technology, 2026From Plant to Nano-Clinic: Advancing Wound Healing with Nano- Encapsulated Rosa damascena Callus Extract
Rosa damascena flower extract · Pharmaceutical Nanotechnology, 2026Assessment of the effects of a topical product containing glycosaminoglycans in cutaneous hydration
Hydrolyzed glycosaminoglycans · International Journal of Clinical Pharmacology Research, 1988Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study
Hydroxypropyl tetrahydropyrantriol, Proxylane · The Journal of Clinical and Aesthetic Dermatology, 2025Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
Np · Skin Pharmacology and Physiology, 2026Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract
Algae exopolysaccharides · Marine Drugs, 2026Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis
Ergothioneine · Frontiers in Nutrition, 2026Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery
Malic acid · Journal of Materials Chemistry. B, 2025Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol · Health Science Reports, 2025The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
Galactomyces ferment filtrate · Skinmed, 2021Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug-Target Interaction Deep Learning-Based Model
Vitamin b12 · Current Issues in Molecular Biology, 2024