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Lancôme vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Lancôme and Sesderma are a French brand founded in 1935 and a Spanish brand founded in 1989, respectively. The French brand is beloved for its sophisticated moisturizers, eye products, serums, and toners formulated with glycerin, hyaluronic acid, and adenosine, while the Spanish brand is beloved for its advanced serums and meticulously engineered formulas. Both suit sensitive skin best, though the former also suits acne-prone skin and the latter suits hyperpigmented and aging skin. They differ in their origins, specific active compositions, and tailored offerings such as the Tonique Confort and Azelac RU Serum.

Lancôme is a French skincare brand founded in 1935 and owned by L'Oréal S.A. since 1964.

loreal.comen.wikipedia.orgcosmeticsbusiness.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Lancôme and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Lancôme vs Sesderma products

Questions and answers

Lancôme or Sesderma: which is better?

Lancôme offers a much wider range of products on this page with High fit levels for sensitive, acne-prone, and dry sensitive skin types, whereas Sesderma features only a single serum. Reviewers frequently note that Lancôme products provide deep hydration and help soothe sensitive skin, though they also mention a high price point.

What is the difference between Lancôme and Sesderma?

Lancôme offers a wide selection of 14 products on this page with various Lovi fit levels across skin types, whereas Sesderma features only a single product, Azelac RU Serum. For dry skin, the products on this page for Lancôme include hydrating options like Tonique Confort with a High Lovi fit level, while Sesderma's serum has a Low Lovi fit level for dry skin.

Which is more affordable, Lancôme or Sesderma?

Reviewers note that Lancôme products on this page have a high price point. The page facts do not provide pricing information for Sesderma.

Which causes fewer breakouts, Lancôme or Sesderma?

For acne-prone skin, the products on this page show that Lancôme fits best, with several items achieving a High Lovi fit level. Sesderma offers Azelac RU Serum, which also has a High fit level for acne-prone skin.

Which brand offers a greater variety of products on this page, and what are their fragrance options?

Lancôme offers a greater variety with 14 products on this page, of which 3 list no fragrance and 11 include fragrance. Sesderma features only 1 product on this page, which contains fragrance.

What are the primary skin types that Lancôme products fit best based on their brand-focused routines?

Based on its brand-focused routines, Lancôme products fit sensitive skin, acne-prone skin, and dry sensitive skin best.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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