Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Niacinamide · Antioxidants, 2021Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Matcha green tea leaf extract camellia sinensis leaf extract, Camellia sinensis, Camellia sinensis extract, Camellia sinensis powder · Carcinogenesis, 2001Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Benzyl alcohol · International Journal of Toxicology, 2001Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments
Rice bran, Stabilized rice bran, Rice bran oil · Journal of Nanobiotechnology, 2011Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf juice powder, Aloe barbadensis leaf juice, Aloe barbadensis leaf extract, Aloe barbadensis, Aloe barbadensis leaf water · Iranian Journal of Medical Sciences, 2019Caffeine's mechanisms of action and its cosmetic use
Caffeine · Skin Pharmacology and Physiology, 2013Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Camellia sinensis extract, Camellia sinensis powder · Journal of the American Academy of Dermatology, 2001Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes
Matcha green tea leaf extract camellia sinensis leaf extract, Camellia sinensis · The Journal of Investigative Dermatology, 2013Improvement of naturally aged skin with vitamin A (retinol)
Retinol · Archives of Dermatology, 2007Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome
Probiotics, Probiotics complex · International Journal of Medical Sciences, 2021Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin
Aha, Aha alpha hydroxy acid, Exfoliants, Micro-acid complex · Journal of Dermatological Science, 2017Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin
Probiotics, Probiotics complex · Experimental Dermatology, 2019Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree extract, Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia tree leaf extract · Indian Journal of Dermatology, Venereology and Leprology, 2007Bacterial cellulose membranes as drug delivery systems: an in vivo skin compatibility study
Cellulose, Microcrystalline cellulose · European Journal of Pharmaceutics and Biopharmaceutics, 2014Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics
Collagen · Dermatology Practical & Conceptual, 2022Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005Effects of menthol and cold on histamine-induced itch and skin reactions in man
Menthol · Neuroscience Letters, 1995Psychophysical study of the effects of topical application of menthol in healthy volunteers
Menthol · Pain, 2006Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin
Saccharum officinarum extract · Journal of Cosmetic Dermatology, 2011Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent
Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015The Effect of Lactobacillus plantarum Extracellular Vesicles from Korean Women in Their 20s on Skin Aging
Probiotics complex · Current Issues in Molecular Biology, 2022Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica
Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015Tea tree oil reduces histamine-induced skin inflammation
Melaleuca alternifolia tree leaf extract · The British Journal of Dermatology, 2002Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol, Bakuchiol · The British Journal of Dermatology, 2019Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng root extract · Journal of Ginseng Research, 2017Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women
Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
Grapefruit seed extract · PloS One, 2016Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
Sodium lauryl sulfate · The Journal of Investigative Dermatology, 2008Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts
Lactic acid · International Journal of Biological Macromolecules, 2024Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomile flower extract, Chamomilla recutita flower extract matricaria flower extract, Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth
Betaine · Journal of Oral Rehabilitation, 2007Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract
Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract · Journal of Ethnopharmacology, 2007Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Centella asiatica extract · Pharmaceutics, 2024The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation
Papain, Carica papaya fruit extract · The Journal of Investigative Dermatology, 2015Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Houttuynia cordata Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway
Houttuynia cordata extract · Plants, 2021Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Bacterial cellulose skin masks-Properties and sensory tests
Cellulose · Journal of Cosmetic Dermatology, 2018Effect of fermentation time on the content of bioactive compounds with cosmetic and dermatological properties in Kombucha Yerba Mate extracts
Saccharomyces xylinum black tea · Scientific Reports, 2021Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Melaleuca alternifolia tree oil leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf juice powder, Melaleuca alternifolia tree extract, Melaleuca alternifolia tree leaf extract, Aloe barbadensis, Propolis extract, Aloe barbadensis extract, Aloe barbadensis leaf water · Clinical Pharmacology, 2018Protective effect of Vaccinium myrtillus extract against UVA- and UVB-induced damage in a human keratinocyte cell line (HaCaT cells)
Vaccinium myrtillus leaf extract fruit · Journal of Photochemistry and Photobiology. B, Biology, 2014Use of Collagen in Cosmetic Products
Collagen · Current Issues in Molecular Biology, 2024A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
Matcha green tea leaf extract camellia sinensis leaf extract, Camellia sinensis · The Journal of Investigative Dermatology, 2019Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds
Rice bran, Stabilized rice bran · Pharmaceutical Biology, 2012Urea: a comprehensive review of the clinical literature
Urea · Dermatology Online Journal, 2013Moringa oleifera Leaf Extracts as Multifunctional Ingredients for "Natural and Organic" Sunscreens and Photoprotective Preparations
Moringa oleifera, Moringa oleifera leaf water · Molecules, 2018Effect of Camellia japonica oil on human type I procollagen production and skin barrier function
Camellia japonica flower extract · Journal of Ethnopharmacology, 2007Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)
Hydrastis canadensis extract · Planta Medica, 2012Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramide, Sphingolipids · Scientific Reports, 2022Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin
Polyethylene · Drug Development and Industrial Pharmacy, 2014Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A
Glycyrrhiza inflata root extract · Journal of the European Academy of Dermatology and Venereology, 2016Hyperoside and Quercitrin in Houttuynia cordata Extract Attenuate UVB-Induced Human Keratinocyte Cell Damage and Oxidative Stress via Modulation of MAPKs and Akt Signaling Pathway
Houttuynia cordata extract · Antioxidants, 2022Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes
Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals
Lemon extract · Molecules, 2020Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
Vitamins a · Clinical, Cosmetic and Investigational Dermatology, 2020Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid · Clinical Oral Investigations, 2021Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation
Green tangerine extract · Photochemical & Photobiological Sciences, 2016Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np · International Journal of Dermatology, 2008Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol · Acta Dermato-venereologica, 2017Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway
Artemisia princeps leaf powder · International Journal of Molecular Sciences, 2017Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol, Tocopherol vitamin e, Ascorbic acid · Journal of Cosmetic Dermatology, 2020Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo
Glycyrrhiza glabra root extract licorice root extract, Licorice root extract, Glycyrrhiza glabra leaf extract licorice leaf extract, Licorice root · Experimental Dermatology, 2015Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study
Retinyl palmitate, Retinyl palmitate vitamin a · International Journal of Nanomedicine, 2021A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations
Arbutin · Journal of Cosmetic Dermatology, 2015Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair
Dipotassium glycyrrhizate · Acta Biomaterialia, 2022Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract, Camellia oleifera leaf extract camellia sinensis leaf extract · Experimental Dermatology, 2009Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris
Azelaic acid · Pharmaceutics, 2021Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913
Protease · Scientific Reports, 2017Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris
Micro-acid complex · Dermatology and Therapy, 2023Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Resveratrol · Molecules, 2023Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia
Menthol · European Journal of Pain, 2014Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia tree oil leaf · Dermatology, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin, Madecassoside · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel
Ascorbyl palmitate · Die Pharmazie, 2005The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
Madecassoside, Asiaticoside · Journal of Alternative and Complementary Medicine, 2020Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study
Taurine · European Journal of Dermatology, 2008α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation
Vaccinium myrtillus leaf extract fruit · Antioxidants, 2021Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway
Lactic acid · Journal of Cosmetic Dermatology, 2023In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract
Ginkgo biloba extract · Clinical, Cosmetic and Investigational Dermatology, 2015Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling
Leontopodium alpinum meristem cell culture · Genes, 2020Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells
Leontopodium alpinum meristem cell culture · Mediators of Inflammation, 2012Synergism of plant extract and vegetable oils-based lipid nanocarriers: Emerging trends in development of advanced cosmetic prototype products
Extract · Materials Science & Engineering. C, Materials for Biological Applications, 2020Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Oleanolic acid · Nanoscale Research Letters, 2020Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties
Algae extract · Journal of Cosmetic Science, 2002Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging
French green clay · Carbohydrate Polymers, 2017Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study
Acerola cherry extract · Dermatologic Therapy, 2022Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment
Calamine · European Journal of Pharmaceutics and Biopharmaceutics, 2016Protective effects of Camellia japonica flower extract against urban air pollutants
Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8, Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin
Silybum marianum seed oil · Experimental and Therapeutic Medicine, 2016A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid, Microclear technology, Bha beta hydroxy acid, Salicylic acid bha, Bha, Bha salicylic acid · BioMed Research International, 2020A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate, Tocopheryl acetate vitamin e · Urologia Internationalis, 2019Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid, Saccharum officinarum extract · Journal of Cosmetic Dermatology, 2019Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies
Citrus reticulata fruit extract tangerine fruit extract · International Journal of Cosmetic Science, 2022High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde
Menthol · The Journal of Pain, 2016Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Vitis vinifera seed extract grape seed extract · International Journal of Cosmetic Science, 2015Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid, Mandelic acid aha · Journal of Cosmetic Dermatology, 2020A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree oil leaf, Melaleuca alternifolia tree extract, Melaleuca alternifolia tree leaf extract · Archives of Dermatological Research, 2022Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011Fermented pomegranate extracts protect against oxidative stress and aging of skin
Punica granatum extract · Journal of Cosmetic Dermatology, 2022Alpha hydroxyacids modulate stratum corneum barrier function
Tartaric acid · The British Journal of Dermatology, 1997Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin, Panthenol, Panthenol vitamin b5 · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycolic acid, Gluconolactone, Saccharum officinarum extract, Pha polyhydroxy acid, Pha blend · Clinical, Cosmetic and Investigational Dermatology, 2019High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin
Witch hazel extract bark twig leaf, Witch hazel water, Witch hazel leaf extract, Witch hazel extract, Witch hazel, Witch hazel leaf water · Phytochemistry, 2001Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021Topical glutathione amino acid precursors protect skin against environmental and oxidative stress
Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin
Panax ginseng root extract · Journal of Ginseng Research, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate, Vc5 crystal technology · Journal of Cosmetic Dermatology, 2019Efficacy of Oxybrasion in the Treatment of Acne Vulgaris: A Preliminary Report
Sea salt · Journal of Clinical Medicine, 2022Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15
Hydrated silica · Antioxidants, 2020A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome
Chamomile flower extract · Complementary Therapies in Clinical Practice, 2015Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica extract, Madecassoside · Molecules, 2023A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone, Pha, Pha polyhydroxy acid · The Australasian Journal of Dermatology, 1992Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Galactomyces ferment filtrate, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Saccharomyces ferment filtrate, Saccharomyces ferment, Aspergillus rice ferment filtrate · Journal of Clinical Medicine, 2021In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract · International Journal of Cosmetic Science, 2020Taurine bromamine (TauBr)--its role in immunity and new perspectives for clinical use
Taurine · Journal of Biomedical Science, 2010Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris
Triethyl citrate · The British Journal of Dermatology, 2007Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 · Annals of Dermatology, 2019Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid, Microclear technology, Bha beta hydroxy acid, Salicylic acid bha, Bha, Micro-acid complex, Bha salicylic acid · Journal of Cosmetic Dermatology, 2024Comparative Study of 35% Glycolic Acid, 20% Salicylic-10% Mandelic Acid, and Phytic Acid Combination Peels in the Treatment of Active Acne and Postacne Pigmentation
Phytic acid, Rice bran extract · Journal of Cutaneous and Aesthetic Surgery, 2019Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide, Calamine · Journal of Controlled Release, 2025The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida ferment filtrate, Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
Asiaticoside · International Journal of Nanomedicine, 2021An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin
Ficus carica fruit extract · Antioxidants, 2021Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np · Skin Pharmacology and Physiology, 2022Efficacy of Topical Treatments for Chrysaora chinensis Species: A Human Model in Comparison with an In Vitro Model
Papain · Wilderness & Environmental Medicine, 2016Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil · Forschende Komplementarmedizin, 2012A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid, Microclear technology, Bha beta hydroxy acid, Salicylic acid bha · Journal of Drugs in Dermatology, 2023Chemical peels for acne vulgaris: a systematic review of randomised controlled trials
Mandelic acid · BMJ Open, 2018Oxidized citrus oil (R-limonene): a frequent skin sensitizer in Europe
Bergamot peel oil · Journal of the American Academy of Dermatology, 2002Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Rice extract · Pharmaceuticals, 2023Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
Azelaic acid · Dermatology and Therapy, 2024Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate, Vc5 crystal technology · European Journal of Pharmaceutics and Biopharmaceutics, 2017A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
Ginkgo biloba leaf extract, Ginkgo biloba extract, Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 20152-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study
2-mercaptonicotinoyl glycine · Journal of Cosmetic Dermatology, 2024A Bayesian network meta-analysis of 14 molecules inhibiting UV daylight-induced pigmentation
2-mercaptonicotinoyl glycine · Journal of the European Academy of Dermatology and Venereology, 2024Antioxidative and skin-whitening effect of an aqueous extract of Salicornia herbacea
Salicornia herbacea extract · Bioscience, Biotechnology, and Biochemistry, 2009Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016Oxidative Stress Protection and Anti-Inflammatory Activity of Polyphenolic Fraction from Urtica dioica: In Vitro Study Using Human Skin Cells
Urtica dioica extract · Molecules, 2025Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study
Arctostaphylos uva-ursi leaf extract · Journal of Cosmetic Science, 2020Safety and efficacy of Sclerocarya birrea (A.Rich.) Hochst (Marula) oil: A clinical perspective
Sclerocarya birrea oil · Journal of Ethnopharmacology, 2015Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Challenging the safety and efficacy of topically applied chlorogenic acid, apigenin, kaempferol, and naringenin by HET-CAM, HPLC-TBARS-EVSC, and laser Doppler flowmetry
Grapefruit seed extract, Grapefruit fruit extract · Frontiers in Chemistry, 2024Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)
Sodium laureth sulfate · Food and Chemical Toxicology, 2001Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial
Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle
Polyethylene · Dermatologic Surgery, 2008Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release
Oenothera biennis flower extract · Biomaterials Advances, 2022Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract, Camellia oleifera leaf extract camellia sinensis leaf extract, Aloe barbadensis flower extract, Camellia sinensis leaf water · Clinical, Cosmetic and Investigational Dermatology, 2019Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid, Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2021New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex
Succinic acid · Journal of Cosmetic Dermatology, 2024Amino acid complex (AAComplex) benefits in cosmetic products: In vitro and in vivo clinical studies
Complex amino acid · Journal of Cosmetic Dermatology, 2022Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure
Saponins · Nutrients, 2022The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study
Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023Photoprotective effect of black tea extracts against UVB-induced phototoxicity in skin
Black tea · Photochemistry and Photobiology, 1999Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010Effects of Cream Containing Ficus carica L. Fruit Extract on Skin Parameters: In vivo Evaluation
Ficus carica fruit extract · Indian Journal of Pharmaceutical Sciences, 2014In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract · Pharmaceutics, 2021The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-8, Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison
Willow bark extract, Willow water bark, Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2019Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
Willow bark extract, Glycyrrhiza glabra leaf extract licorice leaf extract, Willow water bark, Salix nigra bark extract willow bark extract · Planta Medica, 2019An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
Willow bark extract, Willow bark water bark, Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2010Understanding Solar Skin Elastosis-Cause and Treatment
Witch hazel, Witch hazel water, Witch hazel extract · Journal of Cosmetic Science, 2018Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone
Strawberry extract, Raspberry extract · Journal of Drugs in Dermatology, 2013Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study
Beta-glucan · Journal of Cosmetic Dermatology, 2021Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Capryloyl salicylic acid, Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2008Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate · Drug Research, 2017Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations
Complex amino acid · International Journal of Molecular Sciences, 2021Damage and recovery of skin barrier function after glycolic acid chemical peeling and crystal microdermabrasion
Alumina · Dermatologic Surgery, 2004Cosmetic Formulations with Melaleuca alternifolia Essential Oil for the Improvement of Photoaged Skin: A Double-Blind, Randomized, Placebo-Controlled Clinical Study
Melaleuca alternifolia tree extract · Photochemistry and Photobiology, 2023Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin
Butylene glycol · Journal of Cosmetic Dermatology, 2019Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin
Pyrus malus fruit extract · Rejuvenation Research, 2020Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings
Camellia sinensis powder, Camellia sinensis extract · Mini Reviews in Medicinal Chemistry, 2025Standardized extract of wild apple fruit in alkyl-polyglucoside-based cosmetic cream - estimation of stability, safety, antioxidant activity and efficiency
Pyrus malus fruit water · International Journal of Cosmetic Science, 2018Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid · Polymers, 2023Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol
Sorbitol · Journal of Cosmetic Science, 2013Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine, Aloe barbadensis flower extract · Molecules, 2024Effects of lactobionic acid peel, aluminum oxide crystal microdermabrasion, and both procedures on skin hydration, elasticity, and transepidermal water loss
Pha, Lactobionic acid, Pha blend · Journal of Cosmetic Dermatology, 2019Stability and Anti-Aging of Encapsulated Ferulic Acid in Phosphorylated Rice Starch
Rice powder · Molecules, 2022Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Asiatic acid · International Journal of Pharmaceutics, 2024Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial
Vaccinium myrtillus fruit extract, Vaccinium myrtillus leaf extract fruit · Nutrients, 2024The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes
Sucrose · Journal of the European Academy of Dermatology and Venereology, 2022Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers
Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis
Lipase · Lipids, 2020Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits
Bark tree, Betula alba juice · International Journal of Molecular Sciences, 2022Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging
Vitis vinifera seed extract grape seed extract, Grape seed oil · Pakistan Journal of Pharmaceutical Sciences, 2021Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Royal jelly extract · Journal of Cosmetic Dermatology, 2022Final report on the safety assessment of polyethylene
Polyethylene · International Journal of Toxicology, 2007Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda
Mandelic acid, Mandelic acid aha · Journal of Cosmetic Dermatology, 2022Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Papaya enzymes, Papain, Carica papaya fruit extract, Papain extract carica papaya extract, Carica papaya extract fruit ferment · Giornale Italiano Di Dermatologia E Venereologia, 2015Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application
Cyclodextrin · International Journal of Cosmetic Science, 2021Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract, Camellia oleifera leaf extract camellia sinensis leaf extract · Molecules, 2024Skin-Whitening Effect of a Callus Extract of Nelumbo nucifera Isolate Haman
Nelumbo nucifera seed powder · Plants, 2023Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin
Citrus reticulata fruit extract tangerine fruit extract, Extracts fruit · Journal of Cosmetic Dermatology, 2023Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract · Journal of Clinical Medicine, 2023Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid
Betaine · Pharmaceutics, 2024Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with topical pharmacological effect
Hexyl nicotinate · European Journal of Pharmaceutical Sciences, 2003Effects and Mechanism of the Leontopodium alpinum Callus Culture Extract on Blue Light Damage in Human Foreskin Fibroblasts
Leontopodium alpinum meristem cell culture · Molecules, 2023Dyspigmentation, skin physiology, and a novel approach to skin lightening
Raspberry extract · Journal of Cosmetic Dermatology, 2013A new topical biotechnological phytocomplex for truncal mild-moderate acne restores skin microbiota balance
Succinic acid · Skin Research and Technology, 2024Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores
Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate, Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003The evaluation of aluminum oxide crystal microdermabrasion for photodamage
Alumina, Aluminum oxide · Dermatologic Surgery, 2001Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion
Alumina · Dermatologic Surgery, 2002Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Lactobionic acid, Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010Starch- and carboxymethyl cellulose-based films as active beauty masks with papain incorporation
Carica papaya fruit extract, Carica papaya, Carica papaya fruit, Carica papaya extract fruit ferment · International Journal of Biological Macromolecules, 2023A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines
Phytic acid, Rice bran extract · Journal of Cosmetic Dermatology, 2011Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters
Rosmarinus officinalis leaf extract rosemary leaf extract · Antioxidants, 2025Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial
Portulaca oleracea extract · BMC Oral Health, 2023Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate · Journal of Cosmetic Dermatology, 2021Algae extract protection effect on oxidized protein level in human stratum corneum
Algae extract · Annals of the New York Academy of Sciences, 2004A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Shea butter, Aloe barbadensis flower extract · Journal of Cosmetic Dermatology, 2022Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Vitis vinifera seed extract grape seed extract, Grape seed oil · Skin Pharmacology and Physiology, 2007Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera · Polymers, 2022Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Lavandula angustifolia oil lavender oil, Lavandula angustifolia flower extract lavender flower extract · Free Radical Biology & Medicine, 2025Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials
2-mercaptonicotinoyl glycine · Frontiers in Pharmacology, 2025Clinical Efficacy in Skin Hydration and Reducing Wrinkles of Nanoemulsions Containing Macadamia integrifolia Seed Oil
Macadamia oil · Nanomaterials, 2024Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2
Tremella fuciformis sporocarp extract · Photochemical & Photobiological Sciences, 2023Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes
3-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate, Retinyl palmitate vitamin a · Journal of Cosmetic Dermatology, 2013Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum
Diglycerin · Journal of Oleo Science, 2016Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate · Experimental Dermatology, 2012Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer
Galactomyces ferment filtrate, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Saccharomyces ferment filtrate, Saccharomyces ferment, Aspergillus rice ferment filtrate · Journal of Clinical Medicine, 2022A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation-An in vivo/in vitro study
Lactobionic acid · Journal of Cosmetic Dermatology, 2019The effect of Zanthoxylum bungeanum maxim extract on crow's feet: A double-blind, split-face trial
Zanthoxylum bungeanum fruit extract · Dermatologic Therapy, 2019Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation
Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Ginkgo biloba extract · Drug Development and Industrial Pharmacy, 2023Instrumental, clinical and subjective evaluation of the efficacy of a cosmetic treatment for home use
Acetyl glucosamine · Journal of Cosmetic and Laser Therapy, 2019Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-κB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth
Houttuynia cordata extract · Foods, 2024Hexyl-nicotinate-induced vasodilation in normal human skin
Hexyl nicotinate · Dermatologica, 1987Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol · Molecules, 2021Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus extract · International Journal of Biological Macromolecules, 2024Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy
Willow bark water bark · Nanomaterials, 2022Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study
Algae extract · Scientific Reports, 2025Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability
3-o-ethyl ascorbic acid · Journal of Liposome Research, 2025Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation
Ascorbyl palmitate · Journal of Microencapsulation, 2010Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate, Tocopheryl acetate vitamin e · Scientific Reports, 2025Dirt-binding particles consisting of hydrogenated castor oil beads constitute a nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination in a three-step programme of occupational skin protection
Hydrogenated castor oil · The British Journal of Dermatology, 2010Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid, Citric acid, Lipo-hydroxy acid · Journal of Drugs in Dermatology, 2013Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride, Capric triglyceride · Life, 2023Clinical and histologic changes determine optimal treatment regimens for microdermabrasion
Alumina · The Journal of Dermatological Treatment, 2002Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid
Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study
Beta-glucan · The Journal of Dermatology, 2022Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study
Jojoba esters, Hydrolyzed jojoba esters · Journal of Cosmetic Dermatology, 2008Treatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency
Beta-glucan · Dermatology and Therapy, 2023Antioxidant activities and skin hydration effects of rice bran bioactive compounds entrapped in niosomes
Rice bran, Stabilized rice bran · Journal of Nanoscience and Nanotechnology, 2011Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022Tasmannia lanceolata leaf extract alleviates stretch mark appearance in a randomized, placebo-controlled clinical trial in women and stimulates extracellular matrix synthesis in ex vivo human skin explants
Tasmannia lanceolata leaf extract fruit · Journal of Cosmetic Dermatology, 2021Evaulation of irritation potential of surfactant mixtures
Sodium laureth sulfate · International Journal of Cosmetic Science, 1999Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels for topical management of dry skin
Xanthan gum · International Journal of Biological Macromolecules, 2025Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Clinical study of a spray containing birch juice for repairing sensitive skin
Juice, Betula alba juice · Archives of Dermatological Research, 2023Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon
Hexyl nicotinate · The British Journal of Dermatology, 1988Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin
Thermal mud · Journal of the European Academy of Dermatology and Venereology, 2020Evaluation of vulvar irritancy potential of a menstrual pad containing sodium bicarbonate in short-term application
Sodium bicarbonate, Baking soda · The Journal of Reproductive Medicine, 1991Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate, Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021Salicin regulates the expression of functional 'youth gene clusters' to reflect a more youthful gene expression profile
Willow bark water bark · International Journal of Cosmetic Science, 2011Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo
Nelumbo nucifera water root · International Journal of Cosmetic Science, 2023FORMULATION DEVELOPMENT OF TOPICAL CREAM LOADED WITH ANANAS COMOSUS EXTRACT: IN VIVO EVALUATION FOR CHANGES IN SKIN BARRIER FUNCTION USING BIOPHYSICAL TECHNIQUES
Pineapple · Acta Poloniae Pharmaceutica, 2016Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study
Galactomyces ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Galactomyces ferment filtrate pitera ferment filtrate, Saccharomyces ferment filtrate · Journal of Clinical Medicine, 2023Skin irritancy and sensitivity to laundry detergents containing proteolytic enzymes. Part II
Enzyme powder · Berufs-Dermatosen, 1975Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
Pha polyhydroxy acid · Cutis, 2004Skin barrier repair efficacy and safety evaluation of an extract from Gardenia jasminoides J.Ellis
Hydrolyzed gardenia florida extract · Natural Product Research, 2026Preliminary evaluation of a comprehensive skincare regimen for enhancing skin health following advanced optimal pulse technology (AOPT) treatment
Hydrolyzed rhodophyceae extract · International Journal of Cosmetic Science, 2025Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial
Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2023Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Arginine · International Journal of Molecular Sciences, 2024The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration
Lens esculenta fruit extract · Journal of Cosmetic Dermatology, 2024Pleiotropic effects of a Camellia sinensis leaf extract on in vitro and in vivo skin health characteristics
Camellia sinensis leaf water · International Journal of Cosmetic Science, 2025Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study
Zinc gluconate · Journal of Cosmetic Dermatology, 2026Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control
Retinyl palmitate vitamin a · Journal of Clinical Medicine, 2026Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study
Sodium laureth sulfate · International Journal of Pharmaceutics, 2026Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin
Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
Moroccan lava clay · Journal of Cosmetic Dermatology, 2025Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Anti-ageing activities of nanovesicles derived from Artemisia princeps in human dermal cells and human skin model
Artemisia princeps leaf powder · Journal of Extracellular Biology, 2025Topical proteolytic enzymes affect epidermal and dermal properties
Enzyme powder · International Journal of Cosmetic Science, 2007Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery
Malic acid · Journal of Materials Chemistry. B, 2025Evaluation of Saponin-Rich Callus from Saponaria officinalis L. as a Novel Scrub Material with Significant Exfoliating and Anti-Inflammatory Effects
Saponins · Plants, 2025Hydrolyzed corn starch with maltotetraose for skin defense through NRF2 pathway activation in human keratinocytes
Zea mays starch · PloS One, 2026The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
Saccharomyces ferment filtrate · Skinmed, 2021Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Argania spinosa kernel oil argan kernel oil, Shea butter, Saccharide isomerate, Shea butter extract · Lasers in Medical Science, 2025Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration
Sodium pca · Biomaterials Advances, 2026Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
Camellia sinensis leaf powder · Journal of Cosmetic Dermatology, 2023Isolation and characterization of Aureobasidium pullulans from rose rhizosphere: A novel source for skin benefits
Aureobasidium pullulans ferment · International Journal of Cosmetic Science, 2026Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol · Health Science Reports, 2025Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment
Euterpe oleracea fruit extract · Pharmaceutics, 2024Assessing the safety of thermal mineral water for cosmetic applications: an integrated approach using physicochemical, cheminformatics, and bioinformatics techniques
Carbonated water · RSC Advances, 2025A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics
Caprylhydroxamic acid · International Journal of Toxicology, 2025