Medi-Peel Melanon X Cream for dry sensitive skin

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.

  Journal of Cosmetic Science, 2020

• Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.

  Heliyon, 2023

• Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.

  Journal of Cosmetic Dermatology, 2025

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Why other serums fit dry sensitive skin better

• Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

• In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.

  Skin Pharmacology and Physiology, 2026

• Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application.

  Colloids and Surfaces. B, Biointerfaces, 2019

Ingredients

Water, Butyrospermum Parkii Butter Shea Butter, Butylene Glycol, Caprylic Capric Triglyceride, Betaine, Hydrogenated Polydecene, Dimethicone, Niacinamide, Polyglyceryl-3 Methylglucose Distearate, Cetearyl Alcohol, Glyceryl Stearate, Beeswax, Alpha-Arbutin, Magnesium Ascorbyl Phosphate, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Peg-100 Stearate, Dimethicone Vinyl Dimethicone Crosspolymer, Sorbitan Stearate, Sucrose Cocoate, Cysteine, Ascorbic Acid, Carnitine, Tranexamic Acid, Thuja Orientalis Leaf Extract, Polygonum Cuspidatum Root Extract, Witch Hazel Extract, Morus Alba Bark Extract, Phyllanthus Emblica Fruit Extract, Trichosanthes Kirilowii Root Extract, Vitis Vinifera Seed Oil Grape Seed Oil, Jojoba Seed Oil, Hydroxyacetophenone, Ozokerite, Tocopheryl Acetate, Arginine, Ethylhexylglycerin, Carbomer, Sodium Hyaluronate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-3, Sh-Polypeptide-16, Adenosine, Xanthan Gum, Disodium Edta, 1,2-Hexanediol, Glycerin, Propanediol, Broussonetia Extract, Aletris Farinosa Root Extract, Zanthoxylum Schinifolium Leaf Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.