Medicube One Day Exosome Shot 2000 for dry sensitive skin

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Questions and answers

What the research says

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline.

  Journal of Cosmetic Science, 2004

• Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity.

  International Journal of Pharmaceutics, 2008

• A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation.

  Chemical & Pharmaceutical Bulletin, 2010

• Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

  The Journal of Dermatology, 2008

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

  International Journal of Molecular Sciences, 2021

Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.