Medi-Peel Cica Antio Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Why other moisturizers fit skin with dark spots better

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Dipropylene Glycol, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Betaine, Sorbitan Stearate, Arginine, Carbomer, Hydroxyacetophenone, Dimethicone, Caprylyl Glycol, Melia Azadirachta Leaf Extract, Dipotassium Glycyrrhizate, Wheat Extract Sprout, Centella Asiatica Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Ethylhexylglycerin, Curcuma Longa Root Extract, Eclipta Prostrata Extract, Adenosine, Corallina Officinalis Extract, Ocimum Sanctum Leaf Extract, Glyceryl Acrylate Acrylic Acid Copolymer, Solanum Melongena Fruit Extract, Disodium Edta, Allantoin, Aloe Barbadensis Flower Extract, Tocopheryl Acetate, Panthenol, Propylene Glycol, Propanediol, Beta-Glucan, Squalane, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Fructan, Butylene Glycol, Sodium Hyaluronate Crosspolymer, Glyceryl Polymethacrylate, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Butyrospermum Parkii Butter Shea Butter, 1,2-Hexanediol, Olea Europaea Leaf Extract Olive Leaf Extract, Mannan, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Dandelion Leaf Extract, Benzyl Glycol, Ceramide Np, Phytosphingosine, Hydrolyzed Hyaluronic Acid, Rosa Damascena Flower Extract, Rhodiola Rosea Root Extract, Origanum Vulgare Leaf Extract, Palmitoyl Tripeptide-5, Chamaecyparis Obtusa Leaf Extract, Willow Bark Extract, Usnea Barbata Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Lactobacillus Soybean Extract Ferment, Portulaca Oleracea Extract, Citric Acid, Cinnamomum Cassia Bark Extract, Scutellaria Baicalensis Root Extract, Raspberry Ketone, Acetyl Hexapeptide-8, Copper Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Oligopeptide, Palmitoyl Pentapeptide-4, Hexyl Cinnamal, Limonene, Linalool, Citronellol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.