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Phytosphingosine

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Phytosphingosine

Phytosphingosine naturally clears breakouts, repairs the moisture barrier, and smooths fine lines for a healthy look. It suits dry skin and oily skin best, and comes in rich creams. This ingredient fits smoothly into a routine because it works well with bio-placenta peptides, hexapeptides, and acetyl hexapeptide-3.

International Journal of Cosmetic Science, 2007Journal of the European Academy of Dermatology and Venereology, 2002International Journal of Cosmetic Science, 2007

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Phytosphingosine creams

What reviewers say about popular phytosphingosine products

The highlight reviewers mention most for each popular phytosphingosine product on Lovi.

Phytosphingosine for dry skin

Phytosphingosine for oily skin

Phytosphingosine for combination skin

Phytosphingosine for sensitive skin

Phytosphingosine for acne-prone skin

Phytosphingosine for mature skin

What to combine phytosphingosine with

IngredientTogetherHow to use them
Bio-placenta peptides Works well Use them together in the same routine, applying the phytosphingosine first and following with the bio-placenta peptides. Phytosphingosine and bio-placenta peptides
Hexapeptide Works well Use them together by applying the hexapeptide first and the phytosphingosine right after, because lipids help the peptide absorb better. Phytosphingosine and hexapeptide
Acetyl hexapeptide-3 Works well Use them together in the same routine, applying the peptide product first followed by the ceramide cream, for better barrier support. Phytosphingosine and acetyl hexapeptide-3
Collagen peptide Works well Use them together in the same routine, applying the phytosphingosine first and the collagen peptide right after for better skin absorption. Phytosphingosine and collagen peptide
Copper peptide Works well Use them together in the same routine, applying the copper peptide first and the phytosphingosine right after, because lipids help peptides absorb better. Phytosphingosine and copper peptide
Hexapeptide-9 Works well Use them together in the same routine, applying the peptide first and following with the phytosphingosine. Phytosphingosine and hexapeptide-9
Peptide-rich plasma Works well Use them together in the same routine, applying the peptide-rich plasma first and the phytosphingosine right after to boost results. Phytosphingosine and peptide-rich plasma
Triple peptide blend Works well Use them together in the same routine, applying the peptide blend first and the phytosphingosine right after to lock in moisture. Phytosphingosine and triple peptide blend
Palmitoyl pentapeptide-4 Works well Use them together in the same routine, applying the peptide product first and following with the phytosphingosine cream, because they help each other repair the skin. Phytosphingosine and palmitoyl pentapeptide-4
Palmitoyl tripeptide-1 Works well Use them together in the same routine, applying the lipid component first followed by the peptide cream, because lipids help skin absorb peptides better. Phytosphingosine and palmitoyl tripeptide-1

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does phytosphingosine do for the skin?

Phytosphingosine helps fight acne by reducing microbes and inflammation, and it may improve skin hydration and barrier recovery. It also helps repair photoaged skin by supporting collagen production and reducing wrinkles.

International Journal of Cosmetic Science, 2007Journal of the European Academy of Dermatology and Venereology, 2002

How do you use phytosphingosine?

You can use phytosphingosine topically to help soothe the skin and repair its natural barrier. It works well when combined with various peptides in your routine, often applied either before or after depending on the specific peptide pairing.

International Journal of Cosmetic Science, 2007Journal of the European Academy of Dermatology and Venereology, 2002

Should you use phytosphingosine in the morning or at night?

You can use phytosphingosine in your routine day or night. It helps repair the skin barrier and soothe inflammation.

International Journal of Cosmetic Science, 2007Journal of the European Academy of Dermatology and Venereology, 2002

Can you use phytosphingosine every day?

Yes, you can use phytosphingosine every day because it helps repair the skin barrier and provides anti-inflammatory benefits.

Journal of the European Academy of Dermatology and Venereology, 2002International Journal of Cosmetic Science, 2007

Does phytosphingosine cause purging or irritation?

Phytosphingosine is unlikely to cause purging and helps calm irritation, as it demonstrates natural anti-inflammatory activity.

International Journal of Cosmetic Science, 2007

Which skin types is phytosphingosine best for?

Phytosphingosine is a good fit for dry, oily, combination, sensitive, acne-prone, mature, and dark-spotted skin types, with Lovi giving top-tier ratings to products like CeraVe PM Facial Moisturizing Lotion and Cetaphil Ceramide Serum.

International Journal of Cosmetic Science, 2007Journal of the European Academy of Dermatology and Venereology, 2002

Can you use phytosphingosine with bio-placenta peptides?

Yes, you can use phytosphingosine and bio-placenta peptides together in the same routine, applying the phytosphingosine first and following with the bio-placenta peptides.

Research on phytosphingosine

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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