MARY & MAY 6 Peptide Complex Serum for dry sensitive skin
Copper Tripeptide-1
Hexapeptide-11
Hexapeptide-9
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-1
High
- SuperiorDry Skin Fit
- HighEffectiveness
- HighSafety
A great choice for dry sensitive skin; a few serums fit it even better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Cosmetic Science, 2005
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your dry and sensitive skin due to the presence of glycerin and multiple peptides like copper tripeptide-1 and hexapeptide-11, which provide humectant action and support skin hydration and repair.
- The serum offers excellent plumping and firming benefits from peptides such as palmitoyl pentapeptide-4, addressing your dry or flaky skin concerns.
- The safety profile is high, with no risks of irritation for your dry and sensitive skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.6Overall rating based on 2.4k+ reviewsBased on a very large amount of data, users with diverse skin types consistently praise this serum for its lightweight hydration and ability to plump the skin without irritation. While it is not a miracle cure for deep wrinkles, the majority of users report smoother skin texture, improved elasticity, and a reduction in fine lines after consistent use.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs instantly without stickiness”
- “watery texture sinks right in”
- “perfect for layering”
- “leaves no greasy residue”
Gentle & non-irritating Often Mentioned
- “great for my sensitive skin”
- “no stinging or redness”
- “fragrance-free and soothing”
- “didn't break me out”
Hydrating & plumping Often Mentioned
- “skin feels bouncy and soft”
- “plumps up fine lines”
- “provides a nice glow”
- “keeps skin moist all day”
Good value Sometimes Noted
- “better than expensive brands”
- “great price point”
- “affordable peptide option”
- “high quality for the cost”
Subtle or slow results Sometimes Noted
- “didn't see drastic changes”
- “takes months to notice difference”
- “good for maintenance but not a facelift”
- “no miracle for deep wrinkles”
Consumed quickly Rarely Noted
- “bottle finished in 3 weeks”
- “skin drinks it up so I use a lot”
- “small bottle for the amount needed”
Rare skin reactions Rarely Noted
- “caused tiny red bumps”
- “broke me out on forehead”
- “slight itching after application”
- “triggered fungal acne”
Texture too watery Rarely Noted
- “runs down my face quickly”
- “hard to control the dropper”
- “wish it was slightly thicker”
- “feels like water”
Sources: lovi.care, iherb.com, yesstyle.com, skinsort.com, reddit.com, youtube.com, and more
Questions and answers
What makes Mary & May 6 Peptide Complex Serum a great fit for dry sensitive skin?
This serum is a great fit because glycerin and multiple peptides like copper tripeptide-1 and hexapeptide-11 help hold in moisture and support skin repair. It also features palmitoyl pentapeptide-4 to address dry or flaky skin by offering plumping and firming benefits, while being very unlikely to cause irritation.
Which ingredients make this serum a good fit for dry sensitive skin?
Glycerin and multiple peptides like copper tripeptide-1, hexapeptide-11, and palmitoyl pentapeptide-4 make this serum a great fit for dry sensitive skin. They help boost hydration, support skin repair, and plump flaky areas safely without causing irritation.
What does Copper Tripeptide-1 do for dry sensitive skin?
Copper Tripeptide-1 helps calm irritation and protects dry sensitive skin from sun damage while smoothing out wrinkles and supporting a stronger skin barrier. This ingredient may also improve overall firmness and elasticity, though a product for this skin type also needs gentle, soothing hydrators like colloidal oatmeal or plant oils to keep the skin soft and comfortable.
Skin Research and Technology, 2026Journal of Biomaterials Science. Polymer Edition, 2008
What does Hexapeptide-11 do for dry sensitive skin?
Hexapeptide-11 helps make dry, sensitive skin feel more firm and elastic by supporting its natural cellular repair and antioxidant defenses. Because it activates protective cell processes, it is unlikely to irritate easily, but dry skin of this type also needs rich soothing ingredients and gentle moisturizers to stay comfortable and smooth.
Where does this serum go in a skincare routine for dry sensitive skin?
This treatment serum goes in your evening routine after cleansing and toning, followed by your moisturizer. Using it at night helps keep things simple and avoids extra safety concerns around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to hydrate your skin and then following with your retinol. This approach helps keep your dry and sensitive skin calm and comfortable while you use active ingredients.
How often should I use this serum?
You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. It helps hydrate and smooth dry skin with a high safety profile and no expected irritation.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to cause breakouts or clog pores on dry sensitive skin, and it does not cause purging since it lacks active exfoliating ingredients. Its gentle formula has a very safe profile with no harsh ingredients.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.
International Journal of Cosmetic Science, 2005Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks.
Cureus, 2026Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects.
Redox Biology, 2015Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence.
Journal of Cosmetic Science, 2013Topical treatment with cyclized hexapeptide-9 significantly reduced wrinkles and roughness in crow's feet and forehead compared to vehicle, and generally outperformed retinol in healthy volunteers with aging skin.
Journal of Cosmetic Dermatology, 2025A chemically synthesized homotrimeric collagen peptide exhibited high purity, a stable triple-helical conformation, and excellent thermal stability, while safely enhancing collagen and elastin synthesis in fibroblasts in vitro and increasing skin collagen content, improving skin structure, and enhancing microvessel density in BALB/c mice in vivo.
Frontiers in Bioengineering and Biotechnology, 2025The addition of soybean peptide and collagen peptide to normal human dermal fibroblasts increased collagen synthesis and gene expression related to collagen formation, with the highest collagen levels observed when both peptides were added together compared to individual additions.
International Journal of Food Sciences and Nutrition, 2012A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026
Ingredients
Water, Glycereth-26, 1,2-Hexanediol, Butylene Glycol, Glycerin, Arginine, Carbomer, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Adenosine, Caprylyl Glycol, Copper Tripeptide-1, Hexapeptide-11, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Tripeptide-1
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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