Hexapeptide-9

What to combine hexapeptide-9 with

Ingredient	Together	How to use them
Panthenol	Works well	Use them together in the same routine, applying panthenol first to calm your skin before the peptide. Hexapeptide-9 and panthenol
Green tea	Works well	Use them together in the same routine, applying the green tea product first and the hexapeptide-9 product second, because they help each other work better. Hexapeptide-9 and green tea
Ceramide-building complex	Works well	Use them together in the same routine, applying the ceramide-building complex first and the hexapeptide-9 right after, because the lipids help the peptide sink in better. Hexapeptide-9 and ceramide-building complex
Glycerin	Works well	Use them together by applying the glycerin serum before the hexapeptide cream, because hydration helps the peptide sink in better. Hexapeptide-9 and glycerin
Coenzyme Q10	Works well	Use them together in the same routine, applying the peptide serum first and following it with the coenzyme Q10 to boost results. Hexapeptide-9 and coenzyme q10
Vitamin E	Works well	Use them together in the same routine, applying the vitamin E first and the hexapeptide-9 right after, because they help each other work better. Hexapeptide-9 and vitamin E
Bakuchiol	Works well	Use them together in the same routine, applying the bakuchiol first and the hexapeptide-9 right after, because they boost each other's firming power. Hexapeptide-9 and bakuchiol
Silk amino acids	Works well	Use them together by applying the silk amino acids first and the hexapeptide-9 right after, because they help each other boost skin firmness and moisture. Hexapeptide-9 and silk amino acids
Arginine	Works well	Use them together in the same routine, applying the amino acid first and the peptide right after. Hexapeptide-9 and arginine
Liposome	Works well	Use them together, applying the liposome product first and the hexapeptide-9 second, to help the peptide absorb better. Hexapeptide-9 and liposome
Taurine	Works well	Use them together, applying the taurine first and then the hexapeptide-9, because they work well to boost skin moisture and firmness. Hexapeptide-9 and taurine
Hyaluronic acid	Works well	Use them together by applying your hydrating hyaluronic acid serum first, followed by your peptide product, to lock in moisture and help firmness. Hexapeptide-9 and hyaluronic acid
Microcapsule	Works well	Use them together by applying the microcapsules first, because this delivery system helps the hexapeptide sink in better and work more effectively. Hexapeptide-9 and microcapsule
Cholesterol	Works well	Use them together in the same routine, applying the cholesterol cream first and the peptide serum right after. Hexapeptide-9 and cholesterol
Phytosphingosine	Works well	Use them together in the same routine, applying the peptide first and following with the phytosphingosine. Hexapeptide-9 and phytosphingosine
Betaine	Works well	Use them together by applying your betaine product first and your hexapeptide-9 product second, because hydration helps the peptide work better. Hexapeptide-9 and betaine
Phytosterol	Works well	Use them together by applying the peptide serum first, followed by the phytosterol cream, because the plant lipids help the firming peptides absorb better. Hexapeptide-9 and phytosterol
Beta-sitosterol	Works well	Use them together in the same routine, applying the hexapeptide-9 first and the beta-sitosterol right after, because lipids help peptides absorb better. Hexapeptide-9 and beta-sitosterol
Squalene	Works well	Use them together in the same routine, applying the squalene after the hexapeptide-9, because the oil helps the peptide sink in better. Hexapeptide-9 and squalene
Tri-ceramide complex	Works well	Use them together in the same routine, applying the ceramide complex first and the peptide serum right after. Hexapeptide-9 and tri-ceramide complex
GABA	Works well	Use them together morning and night, because they help each other boost skin firmness and moisture. Hexapeptide-9 and GABA
Theanine	Works well	Use hexapeptide-9 and theanine together, applying them both in your morning hydrating routine to support skin firmness and moisture balance. Hexapeptide-9 and theanine
Vitamin C	Depends	Apply your vitamin C in the morning and your hexapeptide-9 at night, because mixing them together can make them less effective. Hexapeptide-9 and vitamin C
Retinol	Depends	Use them at different times of day with the peptide serum in the morning and the retinol at night, because combining them in the exact same routine can cause irritation. Hexapeptide-9 and retinol
Niacinamide	Depends	Use them together in the same routine, applying niacinamide first and hexapeptide-9 right after, because they boost each other's skin benefits. Hexapeptide-9 and niacinamide
Adapalene	Keep apart	Use them at different times of day by applying hexapeptide-9 in the morning and adapalene at night, because combining them in the same routine causes skin irritation. Hexapeptide-9 and adapalene
Glycolic acid	Keep apart	Use them at different times of day with the acid first, because the acid breaks down the peptide and stops it from working. Hexapeptide-9 and glycolic acid
Benzoyl peroxide	Keep apart	Use them at different times of day, with benzoyl peroxide in the morning and hexapeptide-9 at night, because they cancel each other out. Hexapeptide-9 and benzoyl peroxide
Azelaic acid	Keep apart	Use azelaic acid and hexapeptide-9 at different times of day, applying the acid in the morning and the peptide at night, because the acid ruins the peptide. Hexapeptide-9 and azelaic acid
AHA blend glycolic and citric acids	Keep apart	Use them at different times of day, applying the acid first and the peptide later, because the acid is too harsh for the peptide. Hexapeptide-9 and aha blend glycolic and citric acids
Salicylic acid	Keep apart	Use them at different times of day, applying salicylic acid first and hexapeptide-9 later, because the acid is too strong for the peptide. Hexapeptide-9 and salicylic acid
Tretinoin	Keep apart	Use them at different times of day, applying hexapeptide-9 in the morning and tretinoin at night, because combining them in the same routine can cause irritation. Hexapeptide-9 and tretinoin
Vitamin A	Keep apart	Use them at different times of day, applying vitamin A at night and hexapeptide-9 in the morning, to prevent skin irritation. Hexapeptide-9 and vitamin A
Pro-retinol	Keep apart	Use them at different times of day by applying hexapeptide-9 in the morning and pro-retinol at night to avoid skin irritation. Hexapeptide-9 and pro-retinol
Retinal	Keep apart	Use them at different times of day by applying your hexapeptide-9 in the morning and your retinal at night. Hexapeptide-9 and retinal
Copper	Keep apart	Use them on alternate nights because they cancel each other out when applied together. Hexapeptide-9 and copper
Magnesium	Keep apart	Use them at different times of day, applying the peptide first and the magnesium later, because mixing them makes the peptide less effective. Hexapeptide-9 and magnesium
Lactic acid	Keep apart	Use them at different times of day by applying lactic acid in the morning and hexapeptide-9 at night, because acid ruins the peptide. Hexapeptide-9 and lactic acid
Mandelic acid	Keep apart	Apply mandelic acid and hexapeptide-9 at different times of day because the acid destroys the peptide's firmness benefits. Hexapeptide-9 and mandelic acid
Retinoid blend	Keep apart	Use them at different times of day, applying your retinoid at night and hexapeptide-9 in the morning to prevent extra skin irritation. Hexapeptide-9 and retinoid blend
Superoxide dismutase	Keep apart	Use them at different times of day, applying superoxide dismutase first and hexapeptide-9 later, because mixing them breaks down the active ingredients. Hexapeptide-9 and superoxide dismutase
Polyvinyl alcohol	Keep apart	Use them at different times of day, applying hexapeptide-9 first and polyvinyl alcohol later, because mixing them makes the peptide treatment less effective. Hexapeptide-9 and polyvinyl alcohol
Zinc	Keep apart	Apply zinc in the morning and hexapeptide-9 at night, because mixing them together makes the peptide treatment less effective. Hexapeptide-9 and zinc
Zinc sulfate	Keep apart	Use them at different times of day, applying the zinc first, because mixing them together makes the peptide lose its effect. Hexapeptide-9 and zinc sulfate
Bleach	Keep apart	Use them at different times of day, applying the peptide first, because mixing them destroys the peptide's anti-aging power. Hexapeptide-9 and bleach
Granactive retinoid	Keep apart	Use them at different times of day by applying hexapeptide-9 in the morning and granactive retinoid at night to prevent irritation. Hexapeptide-9 and granactive retinoid
Hydroxypinacolone retinoate	Keep apart	Use them at different times of day by applying hexapeptide-9 in the morning and hydroxypinacolone retinoate at night, to avoid extra skin irritation. Hexapeptide-9 and hydroxypinacolone retinoate
Potassium hydroxide	Keep apart	Use them at different times of day with the peptide first, because high alkalinity ruins the peptide. Hexapeptide-9 and potassium hydroxide
Citric acid	Keep apart	Use them at different times of day with citric acid in the morning and hexapeptide-9 at night because acid ruins peptide results. Hexapeptide-9 and citric acid
Isopropyl alcohol	Keep apart	Use them at different times of day, applying the peptide first and the alcohol later, because the alcohol ruins the peptide. Hexapeptide-9 and isopropyl alcohol
Behenyl alcohol	Keep apart	Use them at different times of day, applying the peptide first and the alcohol moisturizer later. Hexapeptide-9 and behenyl alcohol
Protease	Keep apart	Use them at different times of day, applying the hexapeptide-9 first and the protease later, because they cancel each other out. Hexapeptide-9 and protease
Baking soda	Keep apart	Use them at different times of day, applying the peptide first and the baking soda later, because the baking soda is too harsh for the peptide. Hexapeptide-9 and baking soda

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

Research on hexapeptide-9

• Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial

  Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.