La Roche-Posay EFFACLAR DUO+M for mature skin

How to apply

Questions and answers

What the research says

• Capryloyl salicylic acid peel reduced fine lines, wrinkles, and hyperpigmentation comparably to glycolic acid peel in 44 female volunteers, with no statistically significant differences between the two treatments.

  Journal of Cosmetic Dermatology, 2008

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Mannose-6-phosphate complex protects dermis scaffold proteins against oxidation and degradation, improving skin biomechanical properties and reducing crow's feet and neck wrinkle depth and size.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Combining a salicylic acid and lipohydroxy acid facial serum and mask improved closed comedones and acne severity significantly more than serum alone in adults with acne over 8 weeks, with no adverse reactions reported.

  Journal of Cosmetic Dermatology, 2023

• Parity was demonstrated between an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% versus prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025% in participants with mild to moderate acne vulgaris at 12 weeks.

  Cutis, 2012

• Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne.

  Clinical, Cosmetic and Investigational Dermatology, 2023

• Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts.

  International Journal of Cosmetic Science, 2012

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Topical application of specific hexose stereoisomers (altose, idose, mannose, talose, psicose, fructose, sorbose, and tagatose) accelerated epidermal permeability barrier recovery compared to untreated controls in hairless mouse skin after tape stripping.

  Experimental Dermatology, 2011

Ingredients

Water, Glycerin, Niacinamide, Isopropyl Lauroyl Sarcosinate, Propylene Glycol, Peg-20 Methyl Glucose Sesquistearate, Cyclohexasiloxane, Isohexadecane, Sodium Hydroxide, Zinc Pca, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Silica, Silica Silylate, Mannose, Myristyl Myristate, 2-Oleamido-1,3-Octadecanediol, Capryloyl Salicylic Acid, Caprylyl Glycol, Citric Acid, Xanthan Gum, Polysorbate 80, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.