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BIOEFFECT EGF Serum for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

BIOEFFECT EGF Serum

High

  • HighNormal Skin Fit
  • HighEffectiveness
  • ExcellentSafety

A great choice for sensitive skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • This serum offers high suitability for your normal skin and effectively addresses redness and irritation due to the humectant properties of Glycerin and Sodium Hyaluronate, complemented by the soothing and regenerative effects of Hordeum Vulgare Seed Extract and Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1.
  • The presence of Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1 in moderate concentrations further enhances skin regeneration, smoothing texture and providing significant benefits for your specific concerns.
  • The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the inclusion of soothing components.

How to apply

  • Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
  • Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
  • Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
  • Always do a patch test before your first use and avoid getting the serum too close to your eyes .

People Say

★4.7Overall rating based on 600+ reviews

Users with dry, mature, or dehydrated skin highly praise this serum for its deep hydration, plumping effects, and ability to reduce fine lines, resulting in a radiant complexion. Some users with oily or combination skin find the texture sticky or heavy.

Highlights

  • Hydrating and plumping Mostly Mentioned
    • “Gives the skin an instant hydration boost! It's also great for plumping up the skin.”
    • “It felt hydrating and plumping.”
    • “Keeps my skin hydrated and plump.”
    • “Thrilled with the glow and how well moisturized and smooth my skin looks.”
  • Radiant glow Often Mentioned
    • “Gives my 62-year-old skin a beautiful glow!”
    • “Skin looks radiant and is more resilient.”
    • “Complexion has never looked more radiant or even-toned.”
    • “As soon as the serum penetrates my skin, you can see the glow immediately.”
  • Reduces fine lines Often Mentioned
    • “Visible minimizing effect on lines.”
    • “Reduces the appearance of fine lines.”
    • “Deep wrinkle under my eye that has pretty much disappeared!”
    • “Visible improvement in the lines on my forehead.”
  • Expensive product Often Mentioned
    • “Pity that it's so expensive, I'd definitely repurchase.”
    • “Not the best for this price.”
    • “Yes, it's an expensive product.”
    • “Definitely an investment purchase.”
  • Improves texture Sometimes Noted
    • “Skin looks more plumped, smooth and hydrated.”
    • “Real difference in the texture of skin.”
    • “Plumper, smoother and I can get away with minimal makeup.”
    • “Makes my skin look so much smoother, even-toned and brighter.”
  • Sticky texture Sometimes Noted
    • “It feels a bit sticky on the skin.”
    • “Can still feel sticky on my skin.”
    • “It feels like a film on my skin.”
    • “Not absorbing during the night.”
  • Too heavy Rarely Noted
    • “Might be too much for some skin types, especially during the warmer weather.”
    • “Almost a little oily.”
    • “I put it in the evening and it is not absorbing.”

Sources: lovi.care, dermstore.com, cultbeauty.com, bioeffect.com, beauty-detective.com, whowhatwear.com, and more

Questions and answers

What makes BIOEFFECT EGF Serum a great fit for sensitive skin?

This serum is a great fit because it calms redness and irritation while helping smooth your skin using gentle ingredients like glycerin and sodium hyaluronate. It has an excellent safety profile with no harsh ingredients, making it very unlikely to cause irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Pharmacy & Pharmaceutical Sciences, 2015

Which ingredients make this serum a good fit for sensitive skin?

Glycerin and sodium hyaluronate bring moisture to calm redness and irritation, while barley seed extract and rh-oligopeptide-1 help soothe and smooth sensitive skin. This safe formula lacks harsh ingredients, making it very unlikely to cause irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Pharmacy & Pharmaceutical Sciences, 2015

What does EGF do for sensitive skin?

EGF helps calm sensitive skin by supporting barrier recovery and reducing moisture loss after irritation. It also helps protect skin cells from environmental damage and lowers inflammation to keep your face feeling soft and smooth.

Skin Pharmacology and Physiology, 2013

What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.

The British Journal of Dermatology, 2008Acta Dermato-venereologica, 1999

Where does it go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Putting it at night keeps things simple and avoids extra safety concerns around sun exposure.

Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the treatment after your toner and before your moisturizer in your evening routine, making sure to introduce them slowly. This approach is unlikely to cause irritation because the serum features a very safe formula with calming ingredients that help keep sensitive skin comfortable.

Journal of Cosmetic Dermatology, 2024

How often should I use it?

This treatment is applied in the evening as part of your routine. It is a great fit for your sensitive skin and is unlikely to cause irritation.

Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on sensitive skin. It has an excellent safety profile without harsh ingredients, and the inclusion of soothing components helps calm redness and irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Pharmacy & Pharmaceutical Sciences, 2015

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.

    Journal of Pharmacy & Pharmaceutical Sciences, 2015

  • Ketorolac tromethamine poloxamer hydrogel provided sufficient bioavailability to reach the site of action with anti-inflammatory efficacy and no visual skin irritation in volunteers.

    Pharmaceutical Research, 2017

  • Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.

    The New England Journal of Medicine, 1989

  • Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.

    Lasers in Surgery and Medicine, 2020

  • Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.

    The Journal of Clinical and Aesthetic Dermatology, 2022

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Lidocaine at 20% and lidocaine 10% with trometamol provided effective pain control comparable to lidocaine/prilocaine in healthy adults after a 60-minute exposure, while propylene glycol did not accelerate the onset of analgesia.

    Journal of Pain Research, 2017

  • A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks.

    Journal of Cosmetic Dermatology, 2020

  • Tertiary-butyl ammonium and TRIS salts of NSAIDs form supramolecular gels that exhibit biocompatibility and equal anti-inflammatory efficacy to parent drugs, with FLR.TRIS successfully treating inflamed skin in a mice model.

    Chemistry, 2017

Ingredients

Glycerin, Water, Sodium Hyaluronate, Tromethamine, Sodium Chloride, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play