Vitamin C and palmitoyl tripeptide-1
Depends on the strength
Apply vitamin C in the morning and palmitoyl tripeptide-1 at night, because copper complexes can oxidize ascorbate and reduce peptide efficacy. Copper acts as an oxidation catalyst that can diminish the benefits of your vitamin C and peptides. You can separate the two products into different routines or use chelating agents like EDTA.
Microneedle-Mediated Delivery of Copper Peptide Through Skin
Vitamin C products
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Olay
Super Serum
SAR 189.75
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Charlotte Tilbury
Charlotte's Magic Cream
SAR 203.95
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RoC
Retinol Correxion Deep Wrinkle Night Cream
SAR 165.54
-
Paula's Choice
1% Retinol Treatment
SAR 325.00
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Summer Fridays
Jet Lag Mask
SAR 247.03
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Mad Hippie
Vitamin C Serum
SAR 166.32
- Eve Lom Renewal Treatment Oil
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ZO Skin Health
Exfoliating Polish
SAR 328.15
- CeraVe Skin Renewing Vitamin C Serum
-
Eucerin
Anti-Pigment Dual Serum
SAR 90.00
-
RoC
Retinol Correxion Deep Wrinkle Serum
SAR 173.28
-
iS Clinical
Cleansing Complex
SAR 241.37
Palmitoyl tripeptide-1 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
SAR 89.78
- The Ordinary Multi-Peptide + HA Serum
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Medik8
Liquid Peptides
SAR 418.50
-
Shiseido
Benefiance Wrinkle Smoothing Eye Cream
SAR 593.00
-
Clinique
Smart Clinical Repair Wrinkle Correcting Serum
SAR 316.97
- Alastin Skincare Regenerating Skin Nectar
- The Ordinary Matrixyl 10% + HA
-
ZO Skin Health
Daily Power Defense
SAR 662.61
- The INKEY List Collagen Peptide Serum
- Alastin Ultra Nourishing Moisturizer
-
DRMTLGY
Needle-less Serum
SAR 254.55
- Valmont Prime Renewing Pack
Questions and answers
Can you use vitamin C and palmitoyl tripeptide-1 together?
Yes, you can use vitamin C and palmitoyl tripeptide-1 together depending on the strength. Palmitoyl tripeptide-1 pairs well with vitamin C when using stabilized systems or specific products like Image Skincare the MAX Stem Cell Serum and No7 Protect & Perfect Intense Advanced Day Cream. Topical vitamin C effectively treats uneven and wrinkled skin while providing depigmenting properties in patients with melasma and photoaging.
Which goes first, vitamin C or palmitoyl tripeptide-1?
You should use vitamin C and palmitoyl tripeptide-1 in separate routines or choose compatible pH-tolerant peptide products like Image Skincare the MAX Stem Cell Serum and No7 Protect & Perfect Intense Advanced Day Cream to avoid reducing peptide efficacy. Vitamin C helps improve wrinkles and uneven skin tone.
Experimental Dermatology, 2003Journal of Cosmetic Dermatology, 2020
Are vitamin C and palmitoyl tripeptide-1 good for sensitive skin?
Yes, vitamin C and palmitoyl tripeptide-1 work well together depending on the strength, and you can find both ingredients in products like Image Skincare the MAX Stem Cell Serum and No7 Protect & Perfect Intense Advanced Day Cream. Vitamin C helps improve uneven and wrinkled skin while providing depigmenting properties.
Research on vitamin C and palmitoyl tripeptide-1
Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives
Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbic Acid Treatments as Effective and Safe Anti-Aging Therapies for Sensitive Skin
Efficacy of ethyl ascorbyl ether-containing cosmetic cream on blue light-induced skin changes
Moisturizing potentials of ascorbyl palmitate and calcium ascorbate in various topical formulations
Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability
Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
-

Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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