SkinCeuticals P-TOX for oily skin
Advanced Peptide Complex
Hexapeptide
Niacinamide
Laminaria Digitata Extract
High
- HighOily Skin Fit
- HighEffectiveness
- HighSafety
A great choice for oily skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent skin firming for your oily skin due to the advanced peptide complex and hexapeptide, which work to plump and improve elasticity, while niacinamide helps regulate sebum production for oily shine.
- The presence of PHA provides moderate keratolytic action, further supporting the management of oily skin concerns.
- The formula is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing niacinamide.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.4Overall rating based on 2.1k+ reviewsBased on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.
Highlights
Smoother skin Mostly Mentioned
- “definitely gave me a glass skin texture”
- “pores appeared less noticeable after just a few days”
- “increase of smooth skin”
- “skin looks more radiant and smoother”
Hydrating and light Often Mentioned
- “absorbs into my skin quickly”
- “leaves my skin feeling moisturised and glowing”
- “absorbs super quickly”
- “silky, non-greasy, and layers beautifully”
Reduces lines Often Mentioned
- “reduction in some of the finer lines”
- “fine lines around my eyes... fading”
- “crow's feet and my smile lines... became smoother”
- “noticeable reduction in the depth of my wrinkles”
High price point Often Mentioned
- “Too pricey for the hype”
- “It's a bit on the pricey side”
- “Expensive but worth it”
Complements Botox Sometimes Noted
- “really help maintain my Botox”
- “keeps my skin firm, smooth”
- “Great after Botox”
- “prolong the results between visits”
Slow results Sometimes Noted
- “haven't noticed much change on the deeper lines”
- “noticed no changes at all”
- “changes that I did notice were very subtle”
- “one bottle won't eliminate the need for Botox”
Causes breakouts Rarely Noted
- “skin went through a slight purge”
- “my skin had so many whiteheads”
- “Broke out the first week”
- “Something is causing me to breakout”
Sources: lovi.care, dermstore.com, lovelyskin.com, lookfantastic.com, ellemesmedspa.com, reddit.com, and more
Questions and answers
What makes SkinCeuticals P-TOX a great fit for oily skin?
SkinCeuticals P-TOX is a great fit for oily skin because the advanced peptide complex and hexapeptide firm and plump the skin, while niacinamide helps control oily shine. PHA also gently clears pores and the soothing ingredients mean it is unlikely to cause irritation.
American Journal of Clinical Dermatology, 2013International Journal of Molecular Sciences, 2019
Which ingredients make this treatment a good fit for oily skin?
This treatment is a great fit for oily skin because the advanced peptide complex and hexapeptide help plump and improve elasticity, while niacinamide helps control oily shine. Additionally, PHA gently helps manage oily skin concerns, and soothing niacinamide ensures the formula is safe without the risk of irritation.
American Journal of Clinical Dermatology, 2013International Journal of Molecular Sciences, 2019
What does Peptide Complex do for oily skin?
This product helps smooth fine lines and keeps oily skin firm without adding heavy moisture. A peptide complex stimulates skin proteins to improve wrinkles and support the skin structure safely.
What does Hexapeptide do for oily skin?
Hexapeptide is unlikely to directly treat oily skin, but it helps smooth fine lines and make the skin look firmer with twice-daily use. For oily skin, a product of this type needs added ingredients that balance oil and keep pores clear.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
Where does this treatment go in a skincare routine for oily skin?
This treatment goes in the evening routine, applied after cleansing and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure.
Can I use this treatment with retinol, and in what order?
SkinCeuticals P-TOX is a great fit for your oily skin and helps firm while managing oily shine. You may use this treatment alongside retinol by applying retinol first and following with this treatment, or by using retinol on alternating nights to keep your skin calm and comfortable.
How often should I use this treatment?
This treatment is best used in the evening, applying it as part of your nighttime routine. Starting use once a week allows you to see how your skin reacts, and you can carefully use it more often if your skin tolerates it well.
American Journal of Clinical Dermatology, 2013International Journal of Molecular Sciences, 2019
Can this treatment clog pores, cause breakouts or purging for oily skin?
SkinCeuticals P-TOX is unlikely to cause breakouts for oily skin because the formula has a safe profile with soothing niacinamide and no harsh ingredients. Reviewers rarely report breakouts from this treatment.
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years.
International Journal of Molecular Sciences, 2019Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing.
Journal of Cosmetic Dermatology, 2017Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures.
Aesthetic Surgery Journal. Open Forum, 2021Topical tripeptide/hexapeptide formulations (RSN and TFB) applied around medial thigh liposuction accelerated healing, reduced induration, edema, and fluid infiltration, and improved extracellular matrix remodeling compared to a bland moisturizer.
Aesthetic Surgery Journal. Open Forum, 2021Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction.
Journal of Cosmetic Dermatology, 2024Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery.
Journal of Cosmetic Dermatology, 2023Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir.
Frontiers in Microbiology, 2020
Ingredients
Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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