NEOCUTIS Bio Serum Firm for oily acne-prone skin
Rejuvenating Growth Factor
Peptides
Sodium Hyaluronate
Acetyl Glucosamine
Aminopropyl Ascorbyl Phosphate
Average
- HighOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate firming for your oily skin due to Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, which promote elasticity and reduce fine lines, while Aminopropyl Ascorbyl Phosphate and Glycerin provide antioxidant and humectant benefits. This formula is highly suitable for oily skin and generally safe, lacking harsh ingredients and including soothing agents like Sodium Hyaluronate.
- While it provides general hydration and antioxidant support, the formula lacks targeted ingredients to address your primary concerns of acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.6Overall rating based on 500+ reviewsUsers frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.
Highlights
High price Mostly Mentioned
- “Pricey for amount”
- “Little on the pricey side”
- “Expensive growth factor serum”
Hydrating and Plumping Often Mentioned
- “Very hydrating”
- “Plumps my skin as advertised”
- “Big drink of water for my dry skin”
Improves Skin Texture Often Mentioned
- “Saw improved smoothness”
- “Skin texture has improved”
- “Makes my skin feel very smooth”
Reduces Fine Lines Often Mentioned
- “Diminishes the appearance of fine lines”
- “Softens wrinkles”
- “Less visible/apparent right away”
Fast Results Sometimes Noted
- “Saw results immediately”
- “Results in less than a week”
- “Fast results!”
Gentle on Skin Sometimes Noted
- “No issues with sensitive skin”
- “Does not cause irritation”
- “Soothing sensation”
Irritation/Reactions Rarely Noted
- “Burns when I apply it”
- “Acne came back”
- “Insaaane allergic reaction”
Lack of Results Rarely Noted
- “Not seen any difference”
- “Just garden variety humectants”
- “Results are temporary”
Product Pilling Rarely Noted
- “Causes pilling when I put anything on top”
- “Pilling”
Sources: lovi.care, lovelyskin.com, neocutis.com, dermavenue.com, reddit.com, youtube.com, and more
Questions and answers
How well does Bio Serum Firm work for oily acne-prone skin?
This serum works moderately well for your oily skin by offering firming benefits and hydration, though other products fit it better because it lacks targeted ingredients for acne and breakouts. An oily acne-prone skin needs a product with ingredients like niacinamide, propolis, or Vitamin C that control excess oil and target blemishes without causing breakouts.
Journal of Cosmetic Dermatology, 2026Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for oily acne-prone skin?
This serum works for your oily skin because it contains peptides and growth factors that firm the skin, along with sodium hyaluronate and glycerin for hydration. It also has vitamin C derivatives for antioxidant support, though treatments that rate higher for acne-prone skin need targeted ingredients like niacinamide and propolis to control excess oil and clear breakouts.
Journal of Cosmetic Dermatology, 2026Clinical, Cosmetic and Investigational Dermatology, 2017
What does Growth Factor do for oily acne-prone skin?
Growth Factor helps reduce both red, inflamed spots and clogged pores on oily, acne-prone skin. Studies show it supports skin repair and improves acne lesions over several weeks of regular use.
What do Peptides do for oily acne-prone skin?
Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.
Where does this serum go in a skincare routine for oily acne-prone skin?
This treatment goes in the evening routine after cleansing and before moisturizing, which keeps application simple and safe around sun exposure. While it provides good firming and hydration, this skin type needs targeted ingredients like salicylic acid or niacinamide to address breakouts.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following with your retinol after it absorbs. This formula lacks harsh ingredients and is unlikely to irritate oily skin, but to treat acne effectively, it needs targeted ingredients like salicylic acid or benzoyl peroxide.
How often should I use this serum?
This treatment is used in the evening, applying it once a day for your oily skin. Oily and acne-prone skin of this type needs acne-fighting ingredients like salicylic acid, benzoyl peroxide, or retinoids to clear breakouts and prevent blemishes.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is unlikely to clog pores or cause breakouts on oily skin, as it has a very safe formula with soothing ingredients and no harsh irritants. However, because it lacks targeted ingredients for acne and blemishes, oily acne-prone skin needs a product that includes acne-fighting and oil-controlling ingredients like salicylic acid or niacinamide.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Why other serums fit oily acne-prone skin better
A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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