Neutrogena Sensitive Skin Sunscreen Lotion SPF 60+ for mature skin

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Questions and answers

What the research says

• Retinyl palmitate-loaded non-ionic lamellar liquid crystalline systems provided a significant reduction of orbicular wrinkles in human volunteers compared to systems without retinyl palmitate.

  Colloids and Surfaces. B, Biointerfaces, 2011

• A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks.

  Journal of Cosmetic Dermatology, 2013

• Daily sunscreen use reduced skin aging by 24% compared to discretionary use in healthy adults under 55 years, while β-carotene supplementation showed no overall effect.

  Annals of Internal Medicine, 2013

• Microfine titanium dioxide does not penetrate human skin when formulated in an oil-in-water emulsion with the pigment dispersed in the aqueous phase, compared to oily dispersions and liposomal encapsulation which allow deeper skin penetration.

  International Journal of Cosmetic Science, 2000

• Replacing microsized titanium dioxide and zinc oxide with nanoparticles in sunscreens eliminates opaqueness and alters UV protection balance while inducing (photo)cyto- and genotoxicity and penetrating viable skin layers during long-term exposures.

  Nanotechnology, Science and Applications, 2011

• Microfine zinc oxide and titanium dioxide do not penetrate the stratum corneum of porcine skin in vitro, indicating that their use in sunscreens does not pose a health risk from internal exposure.

  Toxicology in Vitro, 2006

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical application of commercial zinc oxide nanoparticles to impaired barrier human skin resulted in a 60-65-fold increase in viable epidermis zinc after 24 hours and a greater than 100-fold increase after 48 hours for both Cct and sweat vehicles compared to the control, with zinc penetrating exclusively as solubilized species rather than nanoparticles.

  ACS Applied Bio Materials, 2020

• Co-exposure to UVB and zinc oxide nanoparticles induces skin toxicity and pyroptosis via NLRP3 inflammasome activation, whereas topical pterostilbene attenuates this damage by decreasing reactive oxygen species and regulating the inflammasome-autophagy-exosome pathway.

  Particle and Fibre Toxicology, 2022

• Topical application of a novel nanoparticulate zinc oxide sunscreen formulation resulted in less than 0.03% zinc penetration through the human epidermis over 24 hours, which was not significantly more than a placebo.

  Skin Pharmacology and Physiology, 2007

• Topical application of a honey, olive oil, and beeswax mixture three times daily for up to 4 weeks resulted in clinical responses in 86% of patients with pityriasis versicolor, 78% with tinea cruris, and 75% with tinea corporis.

  Complementary Therapies in Medicine, 2004

• A prototype body cream containing bee venom, propolis, honey, beeswax, and royal jelly demonstrated stability for 90 days, high antioxidant capacity of 85.45%, lack of cytotoxicity with over 70% cell viability, and no irritation or allergic reaction in dermatological analysis, while improving skin parameters in a panel test.

  Journal of Cosmetic Dermatology, 2022

• MUD1 protected human dermal fibroblasts against AAPH-induced oxidative stress by increasing cell viability, reducing oxidative damage, improving mitochondrial functionality, and enhancing wound healing capacities.

  International Journal of Molecular Sciences, 2018

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Titanium Dioxide, Zinc Oxide, Water, Butyloctyl Salicylate, Beeswax, Styrene Acrylates Copolymer, Silica, Butylene Glycol, Peg-8, Glyceryl Stearate, Peg-100 Stearate, Cetyl Dimethicone, Benzyl Alcohol, Dimethicone, Methicone, Arachidyl Alcohol, Polyhydroxystearic Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Peg-8 Laurate, Xanthan Gum, Isohexadecane, Behenyl Alcohol, Trisiloxane, Ethylhexylglycerin, Disodium Edta, Trimethylsiloxysilicate, Arachidyl Glucoside, Bisabolol, Dipotassium Glycyrrhizate, Triethoxycaprylylsilane, Bht, Polysorbate 60, Stearic Acid, Methylisothiazolinone, Polyaminopropyl Biguanide, Polymethyl Methacrylate, Tocopheryl Acetate, Ascorbic Acid, Pantothenic Acid, Retinyl Palmitate, Alumina

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.