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Sesderma vs Rilastil

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Sesderma and Rilastil are esteemed European skincare brands founded on pharmaceutical expertise and dermatological dedication. Sesderma is beloved for its advanced serums and meticulously engineered formulas, suiting sensitive, hyperpigmented, and aging skin types best with standalone solutions like the Azelac RU Serum for acne-prone skin, while the brand is warmly loved for its targeted serums and meticulously balanced formulas that suit sensitive, dry, and mature skin types best through gentle, deeply nourishing compositions such as the Acnestil for acne-prone skin. Both brands differ in their regional roots and specific active profiles, as botanical extracts and active compounds refine texture and promote radiance in the former, whereas careful restorative compositions restore daily comfort and enhance natural resilience in the latter.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Sesderma and Rilastil products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Sesderma vs Rilastil products

Sesderma vs Rilastil serums and treatments

Questions and answers

Sesderma or Rilastil: which is better?

For acne-prone skin and dark spots, Sesderma offers higher Lovi fit levels than Rilastil on this page, with its Azelac RU Serum rated High for those concerns. However, Azelac RU Serum contains fragrance, while Rilastil products on this page list no fragrance. Azelaic acid helps improve acne vulgaris.

Pharmaceutics, 2021

What is the difference between Sesderma and Rilastil?

For acne-prone skin and skin with dark spots, Sesderma earns a High Lovi fit with its Azelac RU Serum, whereas Rilastil earns an Average fit with Acnestil. The products on this page from Sesderma contain fragrance, while Rilastil products list no fragrance.

Pharmaceutics, 2021

Which is more affordable, Sesderma or Rilastil?

The page facts do not mention the prices of Sesderma or Rilastil, so we cannot tell which brand is more affordable.

Which causes fewer breakouts, Sesderma or Rilastil?

For acne-prone skin, Lovi rates Sesderma's Azelac RU Serum as High, while Rilastil's Acnestil is rated Average. Azelaic acid helps improve acne vulgaris.

Pharmaceutics, 2021

Which brand was founded earlier, Sesderma or Rilastil?

Rilastil was founded earlier, in 1972, while Sesderma was founded in 1989.

Do products from Sesderma or Rilastil contain fragrance?

Sesderma includes fragrance in its Azelac RU Serum on this page. Rilastil products on this page list no fragrance in their ingredients.

Who owns Sesderma and Rilastil?

Grupo Sesderma owns Sesderma, and Istituto Ganassini owns Rilastil.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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