The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study
Melaleuca alternifolia tree oil leaf · Indian Journal of Dermatology, Venereology and Leprology, 2007Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage
Passiflora incarnata flower extract · Journal of Agricultural and Food Chemistry, 2011Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Melaleuca alternifolia tree oil leaf, Aloe barbadensis leaf extract · Clinical Pharmacology, 2018Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract · Experimental Dermatology, 2009Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)
Narcissus tazetta bulb extract · Daru, 2018Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study
Melaleuca alternifolia tree oil leaf · Dermatology, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
Acetyl glucosamine · The British Journal of Dermatology, 2010The Herbal Bitter Drug Gentiana lutea Modulates Lipid Synthesis in Human Keratinocytes In Vitro and In Vivo
Gentiana lutea root extract · International Journal of Molecular Sciences, 2017The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant
Caffeine · Frontiers in Physiology, 2019A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial
Melaleuca alternifolia tree oil leaf · Archives of Dermatological Research, 2022Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-8 · Annals of Dermatology, 2019The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro
Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells
Moringa oleifera seed extract · Drug Delivery, 2022Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl hexapeptide-12 · Journal of Cosmetic Dermatology, 2015Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques
Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)
Sodium laureth sulfate · Food and Chemical Toxicology, 2001Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle
Polyethylene · Dermatologic Surgery, 2008Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial
Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract
Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Cyclopentasiloxane · International Journal of Toxicology, 2011Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging
Narcissus tazetta bulb extract · International Journal of Molecular Sciences, 2018Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone
Pomegranate pericarp extract · Journal of Drugs in Dermatology, 2013Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects
Punica granatum extract · Postepy Dermatologii I Alergologii, 2014Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine
Acetyl glucosamine · Advanced Pharmaceutical Bulletin, 2016Final report on the safety assessment of polyethylene
Polyethylene · International Journal of Toxicology, 2007Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Yeast extract · Journal of Clinical Medicine, 2023Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota
Camellia sinensis leaf extract · Molecules, 2024Tandem repeated irritation in aged skin induces distinct barrier perturbation and cytokine profile in vivo
Toluene · The British Journal of Dermatology, 2012Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate · Arzneimittel-Forschung, 1998Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling
Lavandula angustifolia oil lavender oil · Free Radical Biology & Medicine, 2025Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment
Moringa oleifera seed extract · Polymers, 2022Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol · Molecules, 2021The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026The tandem repeated irritation test: a new method to assess prevention of irritant combination damage to the skin
Toluene · Acta Dermato-venereologica, 2002Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Functional properties and skin care effects of sodium trehalose sulfate
Trehalose · Skin Research and Technology, 2024Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome
Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023Evaulation of irritation potential of surfactant mixtures
Sodium laureth sulfate · International Journal of Cosmetic Science, 1999Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging
Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024Photoprotective, Antioxidant and Anti-Inflammatory Effects of Aged Punica granatum Extract: In Vitro and In Vivo Insights
Punica granatum extract · Food Science & Nutrition, 2025Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study
Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits
Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients
Lactobacillus ferment · International Journal of Cosmetic Science, 2026Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis
Ergothioneine · Frontiers in Nutrition, 2026Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025Protection from combination exposure
Toluene · Current Problems in Dermatology, 2007
