NEOCUTIS Bio Serum Firm for dry skin
Rejuvenating Growth Factor
Peptides
Sodium Hyaluronate
Acetyl Glucosamine
Aminopropyl Ascorbyl Phosphate
High
- HighDry Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for dry skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent firming and plumping for your dry skin due to peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, which work synergistically to enhance skin elasticity and reduce the appearance of fine lines. Sodium hyaluronate and squalane further support hydration, addressing dryness and flakiness effectively.
- The formula is highly suitable for dry skin, with glycerin and squalane providing essential humectant and emollient actions to maintain skin barrier function and prevent moisture loss.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing components like glycerin and squalane.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.6Overall rating based on 500+ reviewsUsers frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.
Highlights
High price Mostly Mentioned
- “Pricey for amount”
- “Little on the pricey side”
- “Expensive growth factor serum”
Hydrating and Plumping Often Mentioned
- “Very hydrating”
- “Plumps my skin as advertised”
- “Big drink of water for my dry skin”
Improves Skin Texture Often Mentioned
- “Saw improved smoothness”
- “Skin texture has improved”
- “Makes my skin feel very smooth”
Reduces Fine Lines Often Mentioned
- “Diminishes the appearance of fine lines”
- “Softens wrinkles”
- “Less visible/apparent right away”
Fast Results Sometimes Noted
- “Saw results immediately”
- “Results in less than a week”
- “Fast results!”
Gentle on Skin Sometimes Noted
- “No issues with sensitive skin”
- “Does not cause irritation”
- “Soothing sensation”
Irritation/Reactions Rarely Noted
- “Burns when I apply it”
- “Acne came back”
- “Insaaane allergic reaction”
Lack of Results Rarely Noted
- “Not seen any difference”
- “Just garden variety humectants”
- “Results are temporary”
Product Pilling Rarely Noted
- “Causes pilling when I put anything on top”
- “Pilling”
Sources: lovi.care, lovelyskin.com, neocutis.com, dermavenue.com, reddit.com, youtube.com, and more
Questions and answers
What makes Neocutis Bio-Serum Firm a great fit for dry skin?
Neocutis Bio-Serum Firm is a great fit for dry skin because it combines peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate to help firm and smooth fine lines while boosting elasticity. Sodium hyaluronate, glycerin, and squalane further support hydration by sealing in moisture and preventing dryness and flakiness without causing irritation.
Journal of Cosmetic Dermatology, 2026Journal of Cosmetic Dermatology, 2015
Which ingredients make this serum a good fit for dry skin?
This serum is a great fit for dry skin because it features peptides like Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate that help firm and smooth the skin. It also includes sodium hyaluronate, squalane, and glycerin to lock in moisture and keep dryness and flakiness away.
Journal of Cosmetic Dermatology, 2026Journal of Cosmetic Dermatology, 2015
What does Growth Factor do for dry skin?
Growth factor helps dry skin by encouraging skin renewal and keeping the outer layer healthy and balanced. It may also help the skin hold onto moisture more effectively.
Wound Repair and Regeneration, 2000Skin Pharmacology and Physiology, 2013
What do Peptides do for dry skin?
Peptides help dry skin by supporting skin barrier health and improving moisture retention. Regular use may also enhance skin firmness and smooth out the texture of dry skin over time.
Where does this serum go in a skincare routine for dry skin?
This serum goes in the evening routine after cleansing and before your moisturizer. Applying it at night helps keep things simple and gives you extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying the serum first to help hydrate and firm your dry skin, followed by your retinol. This approach is unlikely to cause irritation because the formula contains soothing ingredients that help maintain your skin barrier.
How often should I use this serum?
You can use this serum in your evening routine. It helps firm and smooth dry skin while keeping irritation unlikely.
Journal of Cosmetic Dermatology, 2026Journal of Cosmetic Dermatology, 2015
Can this serum clog pores, cause breakouts or purging for dry skin?
This serum is unlikely to clog pores or cause breakouts for your dry skin, as it has a very safe formula with no harsh ingredients and includes soothing components like glycerin and squalane. It is also unlikely to cause purging since it does not contain active exfoliating ingredients that speed up skin cell turnover.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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