Principia vs Sesderma
Principia and Sesderma are skincare lines offering thoughtful cleansers, advanced serums, and precise formulas. The former is widely loved for its cleansers and suits balanced to oily skin best, featuring standout products like the Gel de Limpeza GL-01 for acne-prone skin to maintain a healthy, balanced complexion. Founded in 1989, the Spanish brand is beloved for its meticulously engineered formulas that suit sensitive, hyperpigmented, and aging skin types best. While both brands help refine texture and promote radiance, they differ through Principia's focus on balancing oil and Sesderma's use of botanical extracts and active compounds like the Azelac RU Serum.
Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.
skinexpert.sesderma.comsesderma.com
This page compares some of the most popular Principia and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.
Questions and answers
Principia or Sesderma: which is better?
Sesderma offers a high fit for acne-prone skin and dark spots with its Azelac RU Serum, while the products on this page by Principia earn an average fit across those skin types.
What is the difference between Principia and Sesderma?
Sesderma achieves a High fit for skin with dark spots with its Azelac RU Serum, while the products on this page from Principia reach an Average fit for the same concern. Additionally, Principia lists no fragrance across its products, whereas Sesderma includes fragrance in its serum.
Which is more affordable, Principia or Sesderma?
This public Lovi page does not provide pricing information for either Principia or Sesderma products, so we cannot determine which brand is more affordable.
Which causes fewer breakouts, Principia or Sesderma?
Sesderma fits acne-prone skin with a High Lovi fit level for its Azelac RU Serum, while the products on this page from Principia reach only Average or Low fit levels for acne-prone skin.
Which brand is older, Principia or Sesderma?
Sesderma is older, having been founded in Spain in 1989, while Principia was founded more recently in 2020.
Do either Principia or Sesderma products contain fragrance?
Every product on this page from Principia lists no fragrance in its ingredients, whereas the Azelac RU Serum from Sesderma contains fragrance.
Where were Principia and Sesderma founded?
Sesderma was founded in Spain in 1989, whereas the founding location for Principia is not available.
Research behind their key ingredients
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.
