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Soolantra Cream for dry skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Soolantra Cream

Low

  • AverageDry Skin Fit
  • AverageEffectiveness
  • HighSafety

A weak match for dry skin; the serums alongside fit it better.

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate treatment for inflammatory lesions due to ivermectin, which helps reduce inflammation, and provides general hydration from glycerin supportive for your dry or flaky skin.
  • The formula contains humectant glycerin but lacks sufficient emollient and occlusive ingredients for optimal hydration of dry skin.
  • The product is safe for your dry skin as it contains no prohibited or harsh ingredients that could cause irritation.

How to apply

  • Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
  • Place the serum after cleansing and toner, but right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the serum on slightly damp skin to help lock in extra moisture.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.1Overall rating based on 500+ reviews

A notable portion of users experience an initial worsening of their skin, including breakouts and irritation, during the first few weeks of use before seeing improvements, indicating a need for patience.

Highlights

  • Clears pustules Mostly Mentioned
    • “Cleared all lumps and bumps”
    • “Pustules diminishing after 3 weeks”
    • “Acne-type bumps completely gone”
    • “No new pustules formed”
  • Life-changing results Often Mentioned
    • “Regained my self-confidence”
    • “Best thing I have ever tried”
    • “Miracle cream for my face”
    • “Wish I found this years ago”
  • Reduces redness Often Mentioned
    • “Calming redness significantly”
    • “Redness reduced by 90%”
    • “Skin tone is finally even”
    • “Helps with persistent flushing”
  • Initial flare-up Often Mentioned
    • “Got worse before getting better”
    • “Terrible breakout in first week”
    • “Face erupted with whiteheads initially”
    • “Skin looked awful for two weeks”
  • Improves texture Sometimes Noted
    • “Skin feels baby soft”
    • “Smoother than it has ever been”
    • “Eliminated scabby, peeling skin”
    • “Rough patches smoothed out”
  • High cost Sometimes Noted
    • “Very expensive without insurance”
    • “Price is too high”
    • “Insurance declined coverage”
    • “Cost is a major downside”
  • Slow onset Sometimes Noted
    • “Took 3 months to see results”
    • “Requires patience, not overnight”
    • “Slow process to clear skin”
    • “Didn't work until week 12”
  • Burning or itching Rarely Noted
    • “Mild burning upon application”
    • “Skin felt itchy and irritated”
    • “Stinging sensation for first few days”
    • “Face hurt when touched”

Sources: lovi.care, drugs.com, webmd.com, theindependentpharmacy.co.uk, doctorfox.co.uk, and more

Questions and answers

Why is Soolantra Cream a weak match for dry skin?

Soolantra Cream is a weak match for dry skin because it lacks sufficient rich softening and sealing ingredients for optimal hydration. A treatment for dry skin needs nourishing components like ceramides, niacinamide, peptides, or propolis to properly support and comfort dry skin.

Which ingredients make this cream a poor fit for dry skin?

This cream is a weak match for your dry skin because it lacks sufficient soft, sealing ingredients to lock in moisture. Treatments of this type need rich ingredients like ceramides, niacinamide, and peptides that specifically target hydration and skin barrier support.

What does Glycerin do for dry skin?

Glycerin helps dry skin by drawing in moisture and keeping it locked in, which makes the skin feel much softer and smoother. It also supports your natural skin barrier to stop water from escaping easily. A product for dry skin needs extra ingredients like hyaluronic acid and soothing plant extracts to truly calm and hydrate dry patches.

Clinical, Cosmetic and Investigational Dermatology, 2017The British Journal of Dermatology, 2008

Where does this cream go in a skincare routine for dry skin?

This cream goes in the evening routine after cleansing and before moisturizing, because treatments with active ingredients are best used then for simplicity and safety. Since this is a weak match for dry skin, a product of this type needs extra rich moisturizing ingredients like plant oils or butters and sealing ingredients like petrolatum or waxes to lock in moisture and deeply soften dry skin.

Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first in your evening routine and following it with a rich moisturizer to prevent dryness. This product lacks enough rich, sealing ingredients for dry skin, so it needs added heavy creams and oils to keep the skin smooth and comfortable.

How often should I use this cream?

Use this treatment in the evening as part of your routine. A product of this type needs richer smoothing and sealing ingredients to properly comfort and hydrate dry skin.

Can it clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores on dry skin, though initial flare-ups are commonly reported by users. A product of this type needs rich moisturizing ingredients and oils to keep dry skin fully smooth and comfortable.

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol, stearyl alcohol, and oleyl alcohol are fatty alcohols, which soften the skin.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups.

    Military Medicine, 2024

  • A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate.

    Skin Research and Technology, 2000

  • Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms.

    Clinical and Experimental Dermatology, 2007

  • Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments.

    Journal of Ocular Pharmacology and Therapeutics, 2019

  • Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths.

    International Journal of Nanomedicine, 2016

  • Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation.

    Pharmaceutics, 2024

  • A soap-free cleansing lotion containing cetyl alcohol and sodium cocoyl apple amino acids reduced skin surface impurities and improved skin hydration, barrier function, and skin tone in 27 healthy adult subjects over 30 days.

    Cureus, 2025

Why other serums fit dry skin better

Ingredients

Ivermectin, Glycerin, Isopropyl Palmitate, Carbomer, Dimethicone, Disodium Edta, Citric Acid, Cetyl Alcohol, Stearyl Alcohol, Sorbitan Stearate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Phenoxyethanol, Propylene Glycol, Oleyl Alcohol, Sodium Hydroxide, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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