SkinCeuticals Retinol 1.0 Maximum Strength Refining Night Cream for mature skin
Retinol
Glycerin
Butyrospermum Parkii Butter Shea Butter
Silybum Marianum Milk Extract
Passiflora Incarnata ExtractAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other serums fit it better.
- International Journal of Cosmetic Science, 2017
- Clinical, Cosmetic and Investigational Dermatology, 2017
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Suitable for normal skin, this product contains retinol for desquamation regulation and bisabolol for anti-inflammatory action, which are beneficial for maintaining healthy skin turnover and calming potential irritation.
- While it offers general skincare benefits like hydration and soothing, these are not directly targeted at your primary concern of wrinkles and fine lines.
- The formula is safe for your skin due to the absence of prohibited or harsh ingredients, posing no risk of irritation.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 2.3k+ reviewsBased on a very large amount of data, users consistently describe this cream as a powerhouse professional-grade treatment that delivers dramatic improvements in skin texture, clarity, and firmness, often outperforming prescription alternatives. While the results are highly praised, the majority of reviews emphasize that the retinization period—characterized by peeling, redness, and dryness—is intense and requires a slow, careful introduction to the routine.
Highlights
Effective anti-aging Mostly Mentioned
- “Lines around mouth vanished”
- “Forehead wrinkles significantly reduced”
- “Skin looks years younger”
Refines skin texture Mostly Mentioned
- “Texture is completely gone”
- “Skin feels like porcelain”
- “Smoothest my face has ever been”
Clears acne & pores Often Mentioned
- “Stopped my hormonal breakouts”
- “Pores look invisible now”
- “Faded dark spots from old acne”
Intense irritation Often Mentioned
- “Face peeled like a snake”
- “Burned my sensitive skin”
- “Redness lasted for days”
Fast-acting results Sometimes Noted
- “Saw difference in one week”
- “Woke up glowing”
- “Works faster than other brands”
Drying formula Sometimes Noted
- “Sucked moisture out of skin”
- “Must use heavy cream after”
- “Too drying for winter”
High price point Sometimes Noted
- “Hard on the wallet”
- “Very expensive for the size”
- “Wish it was cheaper”
Packaging design flaws Rarely Noted
- “Metal tube split on the side”
- “Product oozed out of cap”
- “Packaging is frustrating”
Sources: lovi.care, skinceuticals.com, dermstore.com, lovelyskin.com, bluemercury.com, amazon.com, and more
Questions and answers
How well does SkinCeuticals Retinol 1.0 work for mature skin?
This cream works for mature skin, though other products fit it better because its hydrating and soothing benefits are not directly targeted at wrinkles and fine lines. To truly smooth and firm mature skin, a treatment of this type needs high concentrations of potent anti-aging ingredients, powerful antioxidants, and deep-working hydrators.
Which ingredients make this cream a good fit for mature skin?
Retinol makes this cream a good fit for mature skin by helping smooth out fine lines and wrinkles. To work best for mature skin, a treatment of this type needs high concentrations of potent antioxidants, hydrating components, and skin-repairing ingredients that target aging and keep the skin smooth.
What does Retinol do for mature skin?
Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
What does Glycerin do for mature skin?
Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017
Where does this cream go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Mature skin needs products with powerful anti-aging ingredients like potent antioxidants and collagen-boosting peptides to effectively smooth wrinkles and fine lines.
Can I use this cream with glycolic acid, and in what order?
It is best to use glycolic acid and this cream on alternate nights rather than together to help prevent potential irritation. When mature skin needs a strong treatment for fine lines, it works best with ingredients like peptides and concentrated antioxidants that target collagen and firm the skin.
How often should I use this cream?
This treatment is meant for your evening routine, starting at once a week and gradually increasing as your skin adjusts. It is unlikely to cause irritation thanks to its gentle safety profile, but mature skin also needs targeted ingredients like peptides and powerful antioxidants to effectively smooth wrinkles and fine lines.
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to clog pores or cause breakouts on mature skin, though active ingredients like retinol may cause a temporary adjustment period as skin renews. To better target wrinkles and fine lines, a product for this skin needs higher concentrations of collagen-boosting ingredients and targeted anti-aging peptides.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.
Journal of Cosmetic Dermatology, 2024Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.
Journal of Cosmetic Dermatology, 2023Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.
Journal of Cutaneous Medicine and Surgery, 2024Topical chrysin nanoemulgel improved percutaneous absorption and in vitro cytotoxicity on A375 and SK-MEL-2 cell lines compared to unformulated chrysin, demonstrating effective localized transcutaneous delivery.
Pharmaceutics, 2021Chrysin attenuated apoptosis, ROS production, COX-2 expression, and AQP-3 down-regulation induced by UVB and UVA in HaCaT keratinocytes, while showing efficient percutaneous absorption and no skin irritation in animal studies.
Journal of Agricultural and Food Chemistry, 2011Chrysin treatment reduced injury area and inflammation while increasing bFGF secretion, promoting the healing of amiodarone extravasation-induced skin injury in rats compared to control and 10% DMSO groups.
Microvascular Research, 2022
Why other serums fit mature skin better
A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years.
International Journal of Molecular Sciences, 2019A triple peptide complex synergistically stimulated collagen IV production in aged human fibroblasts and reduced periorbital wrinkle parameters compared to placebo in healthy Caucasian volunteers.
Journal of Cosmetic Dermatology, 2010A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.
Journal of Cosmetic Dermatology, 2020
Ingredients
Water, Cyclomethicone, Cyclopentasiloxane, Propylene Glycol, Polysorbate 20, Allyl Methacrylate Crosspolymer, Hydrogenated Lecithin, Caprylic Capric Triglyceride, Butyrospermum Parkii Butter Shea Butter, Dimethiconol, Dimethicone, Dimethicone Peg-7 Isostearate, Retinol, Laureth-23, Laureth-4, Sodium Polyacrylate, Dimethicone Crosspolymer, Glycerin, Polyacrylamide, C13-14 Isoparaffin, Bht, Bisabolol, Tetrasodium Edta, Passiflora Incarnata Flower Extract, Rosa Canina Leaf Extract, Silybum Marianum Fruit Extract, Hypericum Perforatum Extract, Chamomilla Recutita Leaf Extract Matricaria Leaf Extract, Citric Acid, Methylisothiazolinone
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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