SkinCeuticals P-TOX for combination skin
Advanced Peptide Complex
Hexapeptide
Niacinamide
Laminaria Digitata Extract
High
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
A great choice for combination skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin due to the presence of Niacinamide and PHA, which offer seboregulation and moderate exfoliation, respectively, addressing your oily shine.
- The Advanced Peptide Complex and Laminaria Digitata Extract provide additional hydration and soothing benefits, complementing the primary functions for your skin.
- The formula is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.4Overall rating based on 2.1k+ reviewsBased on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.
Highlights
Smoother skin Mostly Mentioned
- “definitely gave me a glass skin texture”
- “pores appeared less noticeable after just a few days”
- “increase of smooth skin”
- “skin looks more radiant and smoother”
Hydrating and light Often Mentioned
- “absorbs into my skin quickly”
- “leaves my skin feeling moisturised and glowing”
- “absorbs super quickly”
- “silky, non-greasy, and layers beautifully”
Reduces lines Often Mentioned
- “reduction in some of the finer lines”
- “fine lines around my eyes... fading”
- “crow's feet and my smile lines... became smoother”
- “noticeable reduction in the depth of my wrinkles”
High price point Often Mentioned
- “Too pricey for the hype”
- “It's a bit on the pricey side”
- “Expensive but worth it”
Complements Botox Sometimes Noted
- “really help maintain my Botox”
- “keeps my skin firm, smooth”
- “Great after Botox”
- “prolong the results between visits”
Slow results Sometimes Noted
- “haven't noticed much change on the deeper lines”
- “noticed no changes at all”
- “changes that I did notice were very subtle”
- “one bottle won't eliminate the need for Botox”
Causes breakouts Rarely Noted
- “skin went through a slight purge”
- “my skin had so many whiteheads”
- “Broke out the first week”
- “Something is causing me to breakout”
Sources: lovi.care, dermstore.com, lovelyskin.com, lookfantastic.com, ellemesmedspa.com, reddit.com, and more
Questions and answers
What makes SkinCeuticals P-TOX a great fit for combination skin?
SkinCeuticals P-TOX is a great fit because Niacinamide and PHA help control oily shine with gentle exfoliation. The advanced peptide complex and laminaria digitata extract also provide extra hydration and keep combination skin feeling soft and calm.
Which ingredients make this treatment a good fit for combination skin?
Niacinamide and PHA make this treatment a great fit because they help control oily shine and gently smooth combination skin. The advanced peptide complex and laminaria digitata extract also provide extra moisture and keep your skin calm.
What does Peptide Complex do for combination skin?
Peptide Complex helps hydrate combination skin, improve elasticity, and smooth the look of lines with daily use. It is unlikely to cause irritation and may also help firm the skin over time.
Journal of Cosmetic Dermatology, 2019Journal of Cosmetic Dermatology, 2023
What does Hexapeptide do for combination skin?
Hexapeptide helps keep combination skin smooth and hydrated while targeting fine lines, although its low skin penetration can limit how much gets absorbed. It may also help balance oily areas by reducing sebum production, making it a versatile option for mixed skin types.
International Journal of Molecular Sciences, 2025International Journal of Cosmetic Science, 2022
Where does this treatment go in a skincare routine for combination skin?
This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Putting it in the evening helps keep your skin safe around sun exposure, and you can start using it once a week before trying it more often.
Can I use this treatment with retinol, and in what order?
You can use this treatment alongside retinol by applying it at night after cleansing and toning, and before your moisturizer. Since the formula is gentle and lacks harsh ingredients, it is unlikely to cause irritation when combined thoughtfully.
How often should I use this treatment?
Use this treatment in your evening routine, applying it once a week to start, and carefully use it more often if your skin tolerates it well and shows good results. Niacinamide and PHA help control oily shine while keeping your skin calm and smooth.
Can this treatment clog pores, cause breakouts or purging for combination skin?
This treatment is unlikely to cause breakouts on combination skin because it has a safe formula with soothing ingredients and no harsh components. Reviewers rarely mention breakouts, and the product is a great fit for your skin type.
What the research says
Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing.
Journal of Cosmetic Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures.
Aesthetic Surgery Journal. Open Forum, 2021Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction.
Journal of Cosmetic Dermatology, 2024Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery.
Journal of Cosmetic Dermatology, 2023Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir.
Frontiers in Microbiology, 2020
Ingredients
Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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