SENTÉ Dermal Repair Cream for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.

  Journal of Cosmetic and Laser Therapy, 2019

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A topical eye cream containing low molecular weight heparan sulfate and naturally derived extracts improved periorbital hyperpigmentation, fine and coarse wrinkles, puffiness, and dark circles in 15 subjects over 12 weeks.

  Journal of Cosmetic Dermatology, 2019

• Topical low molecular weight heparan sulfate improved periorbital discoloration and wrinkles starting at week two with continuous improvement up to week 12.

  Journal of Cosmetic Dermatology, 2020

• Topical low molecular weight heparan sulfate improved skin hydration, firmness, elasticity, barrier function, and fine lines and wrinkles in 15 patients over 8 weeks.

  Journal of Drugs in Dermatology, 2015

• Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.

  Journal of Cosmetic Dermatology, 2007

• N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.

  Advanced Pharmaceutical Bulletin, 2016

• Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period.

  Journal of Cosmetic Dermatology, 2013

• Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs.

  BMC Veterinary Research, 2020

• Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling.

  International Journal of Molecular Medicine, 2018

• Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines.

  International Journal of Biological Macromolecules, 2017

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• Topical application of an argan oil NLC-based hydrogel formulation increased skin hydration in healthy volunteers over a one-month period through a synergistic effect of NLC occlusion and argan oil hydration.

  International Journal of Nanomedicine, 2014

• Incorporating allantoin into argan oil enriched liposomes improved its accumulation in the dermis (~8.7μg/cm(2)) and permeation through the skin (~33μg/cm(2)) compared to conventional liposomes, water dispersion, and a commercial gel.

  International Journal of Pharmaceutics, 2016

Ingredients

Water, Caprylic Capric Triglyceride, C12-15 Alkyl Benzoate, Glycerin, Cetearyl Alcohol, Argania Spinosa Kernel Oil, Heparan Sulfate, Acetyl Glucosamine, Ethylhexyl Palmitate, Glyceryl Stearate, Peg-100 Stearate, Potassium Cetyl Phosphate, Cyclopentasiloxane, Dimethicone, Butylene Glycol, Tocopheryl Acetate, Tocopherol, Sodium Hyaluronate, Camellia Sinensis Leaf Extract, Chenopodium Quinoa Seed Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, 1,2-Hexanediol, Caprylyl Glycol, Disodium Edta, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Sorbic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.