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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

Average

  • HighOily Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for oily acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate exfoliation and antioxidant benefits for your oily skin with lactic acid and tetrahexyldecyl ascorbate, which help balance sebum production and provide overall skin improvement.
  • Glycerin and macadamia ternifolia seed oil offer excellent hydration and elasticity, though the formula lacks specialized ingredients to directly target your acne, blemishes, and breakouts.
  • The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
  • Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
  • Gently press a small amount into your skin and avoid rubbing to keep pores clear.
  • Apply on clean, slightly damp skin to help the product absorb better and control oil.
  • Avoid the sensitive eye area and do a simple patch test before your first use.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

How well does Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer work for oily acne-prone skin?

This moisturizer works moderately well for oily acne-prone skin, providing balanced hydration and antioxidants without causing irritation, but it lacks ingredients that directly target breakouts. Oily acne-prone skin needs lightweight hydration and specialized blemish-fighting ingredients that clear pores and soothe active breakouts.

European Journal of Pharmaceutics and Biopharmaceutics, 2017

Which ingredients make this cream a good fit for oily acne-prone skin?

Lactic acid and tetrahexyldecyl ascorbate help balance your oil and smooth your skin. To truly fit oily acne-prone skin well, a product of this type needs specialized ingredients that directly target acne, blemishes, and breakouts.

What does Acyl-Glutathione do for oily acne-prone skin?

Acyl-glutathione helps protect the skin against sun-induced redness and may improve overall tone. This type of product for oily, acne-prone skin needs ingredients that reduce breakouts and soothe irritation while balancing oil.

The Journal of Clinical and Aesthetic Dermatology, 2025Giornale Italiano Di Dermatologia E Venereologia, 2019

What does Vitamin C do for oily acne-prone skin?

Vitamin C helps calm red and irritated skin and may improve the look of post-acne marks when used as part of your routine. For oily and acne-prone skin, this type of product also needs soothing ingredients and lightweight hydrators that keep pores clear without feeling heavy.

European Journal of Pharmaceutics and Biopharmaceutics, 2017Archives of Dermatological Research, 2024

Where does it go in a skincare routine for oily acne-prone skin?

This moisturizing treatment goes in the morning and evening routine after your toner and before your sunscreen. A product of this type needs specialized ingredients that directly target your acne, blemishes, and breakouts to work best for oily acne-prone skin.

Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol, applying it after your retinol treatment to help buffer potential dryness. This type of routine for your oily acne-prone skin needs lightweight hydration, oil-balancing ingredients, and targeted blemish-fighting components like salicylic acid or benzoyl peroxide to properly care for breakouts.

Cutis, 2006

How often should I use it?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular application helps keep your skin soft while providing gentle exfoliation and moisture, though oily and acne-prone skin also needs specialized blemish-targeting ingredients to stay clear.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to cause irritation on your oily skin, but it lacks specialized ingredients to directly target acne, blemishes, and breakouts. Oily acne-prone skin needs targeted blemish-fighting ingredients and oil-balancing components to truly thrive.

Can I use it around the eyes or on my body?

This moisturizer is safe to use on your body and around the eyes, though the skin on your body is much thicker than the very thin skin in the eye area. Its ingredients help hydrate and improve skin texture safely across these areas.

Surgical and Radiologic Anatomy, 2002

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Why other moisturizers fit oily acne-prone skin better

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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