Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer for oily acne-prone skin
Acyl-Glutathione
Niacinamide
Shea Butter
Lactic Acid
Vitamin F BlendAverage
- AverageOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily acne-prone skin; other moisturizers fit it better.
- Journal of the European Academy of Dermatology and Venereology, 2024
- Clinical, Cosmetic and Investigational Dermatology, 2014
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your oily skin, as niacinamide helps regulate sebum production, but it lacks sufficient mattifying ingredients for optimal oil control.
- The formula provides excellent moisturization with shea butter and dimethicone, supporting barrier resilience, though these ingredients are not specifically targeted for your acne and breakouts.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
Questions and answers
How well does Perricone MD Intensive Overnight Moisturizer work for oily acne-prone skin?
This moisturizer works moderately well for oily acne-prone skin because niacinamide helps balance oil, but it lacks enough mattifying ingredients to control shine. While shea butter and dimethicone soften and protect the skin barrier, this type of skin needs lightweight, oil-free hydration and targeted blemish-fighting ingredients that clear breakouts without clogging pores.
Which ingredients make this cream a good fit for oily acne-prone skin?
Niacinamide, shea butter, and dimethicone make this cream a moderate fit for your oily acne-prone skin by helping balance oil and keeping skin soft, though this skin type needs lighter, mattifying ingredients and targeted blemish treatments for an ideal fit.
What does Acyl-Glutathione do for oily acne-prone skin?
Acyl-glutathione helps protect the skin against sun-induced redness and may improve overall tone. This type of product for oily, acne-prone skin needs ingredients that reduce breakouts and soothe irritation while balancing oil.
The Journal of Clinical and Aesthetic Dermatology, 2025Giornale Italiano Di Dermatologia E Venereologia, 2019
What does Niacinamide do for oily acne-prone skin?
Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024
Where does this cream go in a skincare routine for oily acne-prone skin?
This moisturizing treatment goes in the evening routine, applied as the last step after your cleanser, toner, and treatment. While it works for oily skin and helps regulate oil, it lacks sufficient mattifying ingredients, so oily skin types generally need lightweight, oil-controlling ingredients and dedicated blemish-fighting actives for optimal breakout control.
Can I use this cream with retinol, and in what order?
You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer at night to keep your skin soft and comfortable. This type of routine needs a product that includes barrier-supporting and soothing ingredients to help prevent dryness and irritation while using retinol.
How often should I use this cream?
You can use this moisturizing treatment in the evening as part of your routine. Daily application helps keep your skin soft and smooth, though an oily skin type needs added mattifying ingredients and targeted breakout treatments for optimal care.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?
Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer is a moderate fit for your oily acne-prone skin because it lacks sufficient mattifying ingredients for oil control, and its rich ingredients like shea butter are not specifically targeted for breakouts. This cream is unlikely to cause irritation since it leaves out harsh ingredients and includes soothing components, but a product of this type needs lightweight, oil-absorbing ingredients and targeted blemish-fighting components for optimal care.
Can I use this cream around the eyes or on my body?
This moisturizing treatment is safe to use around the eyes or on the body, though oily acne-prone skin needs a product of this type that also provides targeted oil control and blemish-clearing ingredients.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool).
What the research says
Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.
Cutis, 2004Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.
Journal of the American Academy of Dermatology, 1992A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.
The Journal of Clinical and Aesthetic Dermatology, 2020Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites.
Clinical and Experimental Dermatology, 1998Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face.
The Journal of Clinical and Aesthetic Dermatology, 2017Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin.
Biological & Pharmaceutical Bulletin, 2004
Why other moisturizers fit oily acne-prone skin better
A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Butyrospermum Parkii Butter Shea Butter, Myristyl Myristate, Niacinamide, C12-15 Alkyl Benzoate, Stearic Acid, Dimethicone, Sodium Acrylates Copolymer, Palmitoyl Glycine, S-Palmitoylglutathione, Ethylhexylglycerin, Myristyl Laurate, Ribose, Lecithin, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Salvia Hispanica Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Glyceryl Stearate, Peg-100 Stearate, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.