Perricone MD Cold Plasma Plus+ for oily acne-prone skin
Ascorbic Acid Ester
Copper Tripeptide
Acetyl Hexapeptide-8
Omega 3
Glycolic AcidAverage
- AverageOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your oily skin due to the presence of Glycolic Acid for mild exfoliation, but lacks sufficient seboregulating ingredients for optimal oil control.
- The formula provides general skincare benefits like hydration and soothing from Glycerin and Sodium Hyaluronate, which are supportive for acne-prone and oily skin, but it does not contain targeted ingredients for significant acne or oil control.
- The product is safe for your oily skin with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.2Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.
Highlights
Unpleasant scent Mostly Mentioned
- “smells like fish”
- “scent is off-putting”
- “earthy and funky smell”
- “hard to get past the smell”
Improves skin texture Often Mentioned
- “smooths my skin overnight”
- “minimized my large pores”
- “texture is not grainy anymore”
- “skin feels fantastic”
High price tag Often Mentioned
- “very expensive product”
- “not worth the money”
- “price is steep”
- “waiting for a sale”
Fast absorption Sometimes Noted
- “absorbs pretty quickly”
- “sinks right in”
- “lightweight and not sticky”
- “non-greasy finish”
Increases radiance Sometimes Noted
- “saw more radiance”
- “brightening dark spots”
- “skin looks youthful”
- “helps with dullness”
Reduces fine lines Sometimes Noted
- “softens crow's feet”
- “lines appear diminished”
- “helps with wrinkles”
- “skin looks plumper”
Packaging issues Rarely Noted
- “jar is unsanitary”
- “pump stopped working”
- “hard to get product out”
- “prefer a bottle”
Skin irritation Rarely Noted
- “caused redness and burning”
- “broke me out”
- “too strong for sensitive skin”
- “caused dry patches”
Sources: lovi.care, ulta.com, perriconemd.com, amazon.com, sephora.co.uk, lovelyskin.com, and more
Questions and answers
How well does Cold Plasma Plus+ work for oily acne-prone skin?
Perricone MD Cold Plasma Plus+ offers moderate suitability for oily skin with glycolic acid for mild exfoliation and glycerin for hydration, but it lacks sufficient oil-control ingredients. A treatment of this type needs targeted ingredients like niacinamide and propolis to properly manage excess oil and acne.
Which ingredients make this treatment a good fit for oily acne-prone skin?
Glycolic Acid makes this treatment a fit for your oily skin by providing mild exfoliation, while Glycerin and Sodium Hyaluronate add supportive hydration and soothing. To work best for oily acne-prone skin, a treatment of this type needs effective ingredients like niacinamide and propolis that control excess oil and target blemishes safely.
What does Ascorbic Acid do for oily acne-prone skin?
Ascorbic acid helps brighten dark spots and calms oily, breakout-prone skin when used regularly. It is generally well-tolerated and may help improve skin texture and reduce blemishes.
What does Copper Tripeptide do for oily acne-prone skin?
Copper Tripeptide helps soothe oily and acne-prone skin while supporting a clear, smooth look. For the best results on this skin type, a product of this type needs calming ingredients and oil-balancing benefits.
Where does this treatment go in a skincare routine for oily acne-prone skin?
This treatment goes in the evening routine, as a step after cleansing and toning and before moisturizing. It works for your oily skin, though an oily skin product of this type needs targeted oil-controlling ingredients for optimal oil management.
Can I use this treatment with niacinamide, and in what order?
You can use this treatment alongside niacinamide by applying niacinamide first and following with this product once it absorbs. This routine helps keep your oily, acne-prone skin calm and hydrated without causing irritation. Products for this skin type work best when they also include strong oil-controlling ingredients.
How often should I use this treatment?
You can use this treatment in the evening as part of your routine. Start by using it once a week, and if your skin feels comfortable and you see good results, you can carefully use it more often. To work best for oily acne-prone skin, a product of this type needs targeted ingredients for significant acne and oil control.
Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?
This treatment is unlikely to cause breakouts or clog pores on oily acne-prone skin because it contains no harsh or prohibited ingredients, though a product of this type needs targeted oil-control ingredients and balancing agents for optimal care.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017
Why other serums fit oily acne-prone skin better
A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Specialist dermatologist, MBBS, MD, IFAAD
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Elina Nazarenko, MD
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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