Murad Retinal ReSculpt Overnight Treatment for mature skin

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Questions and answers

What the research says

• Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo.

  Skin Research and Technology, 2024

• Colloidal oatmeal induced skin barrier-related gene expression in vitro and showed significant clinical improvements in skin dryness, moisturization, and barrier in 50 healthy female subjects treated with a colloidal oatmeal lotion.

  Journal of Drugs in Dermatology, 2016

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• A multiple W/O/W emulsion containing Rosmarinus officinalis L., Avena sativa L., and Linum usitatissimum L. extracts showed no irritant, phototoxic, inflammatory, or allergenic potential in human skin models and patch tests, establishing its safety as a cosmetic base.

  Pharmaceutics, 2021

• Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.

  Journal of Cosmetic Dermatology, 2018

• Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.

  Dermatology, 2002

• Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.

  Dermatology, 1999

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Colloidal oat increased the growth rate, metabolism, and lactic acid production of Staphylococcus epidermidis compared to Staphylococcus aureus in vitro, matching clinical increases in lactic acid on dry skin after 6 weeks of lotion use.

  Clinical, Cosmetic and Investigational Dermatology, 2021

• Topical 40% urea cream achieved improvement in less time and showed superiority over 12% ammonium lactate lotion in skin roughness, fissure reduction, thickness, and dryness at day 14 in patients treated for moderate to severe xerosis.

  American Journal of Clinical Dermatology, 2002

• Topical treatment with K101 achieved a significantly higher mycological cure rate compared to placebo in patients with ≤50% nail involvement (27.2% vs 10.4%), while showing early visible improvements in nail appearance and no safety issues.

  Mycoses, 2012

Ingredients

Water, Diisostearyl Malate, Pentylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Zea Mays Kernel Extract, Squalane, Propanediol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycerin, Cetearyl Alcohol, Glyceryl Ricinoleate, Avena Sativa Kernel Extract Oat Kernel Extract, Butyrospermum Parkii Butter Shea Butter, Retinal, Urea, Yeast Amino Acids, Trehalose, Inositol, Taurine, Betaine, Anigozanthos Flavidus Extract, Phosphatidylcholine, Olea Europaea Leaf Extract Olive Leaf Extract, Mannitol, Ethylhexylglycerin, Dimethyl Isosorbide, Glyceryl Stearate, Sodium Stearoyl Glutamate, Cetyl Alcohol, Hectorite, Xanthan Gum, Sodium Chloride, Polysorbate 60, Sorbitan Isostearate, Leuconostoc Radish Root Ferment Filtrate, Tetrasodium Glutamate Diacetate, Citric Acid, Sodium Benzoate, Chlorphenesin, Potassium Sorbate, Citronellol, Alpha-Isomethyl Ionone, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.