MISSHA All Around Safe Block Soft Finish Sun Milk for acne-prone skin

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Questions and answers

What the research says

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Liposomal encapsulation of octyl methoxycinnamate increases its safety, skin affinity, and in vivo solar photoprotection factor while slowing its release and enhancing retention in the stratum corneum compared to a conventional formulation.

  International Journal of Nanomedicine, 2013

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Microfine titanium dioxide does not penetrate human skin when formulated in an oil-in-water emulsion with the pigment dispersed in the aqueous phase, compared to oily dispersions and liposomal encapsulation which allow deeper skin penetration.

  International Journal of Cosmetic Science, 2000

• Replacing microsized titanium dioxide and zinc oxide with nanoparticles in sunscreens eliminates opaqueness and alters UV protection balance while inducing (photo)cyto- and genotoxicity and penetrating viable skin layers during long-term exposures.

  Nanotechnology, Science and Applications, 2011

• Microfine zinc oxide and titanium dioxide do not penetrate the stratum corneum of porcine skin in vitro, indicating that their use in sunscreens does not pose a health risk from internal exposure.

  Toxicology in Vitro, 2006

• Maximal topical applications of 6% bemotrizinol in a model sunscreen formulation did not result in meaningful systemic exposure in humans.

  Regulatory Toxicology and Pharmacology, 2023

• Application of creams and emulgels containing immortelle extract and hemp oil increased skin hydration and reduced TEWL in 25 healthy volunteers compared to placebo samples and a non-treated control, with emulgels demonstrating enhanced herbal active delivery and better sensory properties than creams.

  Pharmaceutics, 2021

• Polypropylene non-woven fabric impregnated with H. italicum extract using ethanol as a cosolvent demonstrated significantly greater potential for skin protection compared to other investigated samples on artificially irritated human skin without causing irritation or redness.

  Journal of Ethnopharmacology, 2023

• A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use.

  Dermatology and Therapy, 2020

• Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups.

  Military Medicine, 2024

• A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate.

  Skin Research and Technology, 2000

• Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms.

  Clinical and Experimental Dermatology, 2007

Ingredients

Water, Cyclopentasiloxane, Silica, Zinc Oxide, Dipropylene Glycol, Butylene Glycol, Lauryl Peg-10 Tris Trimethylsiloxy Silylethyl Dimethicone, Ethylhexyl Salicylate, Caprylyl Methicone, Ethylhexyl Methoxycinnamate, Isopropyl Palmitate, Titanium Dioxide Ci 77891, Alcohol Denat, C12-15 Alkyl Benzoate, Helichrysum Italicum Extract, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Magnesium Sulfate, Dimethicone Vinyl Dimethicone Crosspolymer, Dimethicone, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Quaternium-18 Bentonite, Aluminum Hydroxide, Stearic Acid, Hydrogen Dimethicone, Glycerin, Phenoxyethanol, Silica Dimethyl Silylate, Sodium Benzoate, Disodium Edta, Tocopheryl Acetate, Potassium Sorbate, Caprylyl Glycol, Polyhydroxystearic Acid, Isostearic Acid, Lecithin, Ethylhexyl Palmitate, Polyglyceryl-3 Polyricinoleate, Ci 77492, Limonia Acidissima Extract, Ci 77491, Vp Hexadecene Copolymer, Acrylates Dimethicone Copolymer, Biosaccharide Gum-4, Rosa Davurica Bud Extract, Cinchona Succirubra Bark Extract, Aloe Barbadensis Leaf Extract, Abronia Villosa Leaf Extract, Psidium Guajava Leaf Extract, Rhodiola Rosea Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.